ID A0A287APN6_PIG Unreviewed; 1900 AA.
AC A0A287APN6;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Polybromo 1 {ECO:0000313|Ensembl:ENSSSCP00000046027.1};
DE SubName: Full=Protein polybromo-1 isoform X13 {ECO:0000313|EMBL:HDB64859.1};
GN Name=PBRM1 {ECO:0000313|Ensembl:ENSSSCP00000046027.1,
GN ECO:0000313|VGNC:VGNC:91202};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000046027.1, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000046027.1, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000046027.1,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HDB64859.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000046027.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; DQIR01209382; HDB64859.1; -; Transcribed_RNA.
DR Ensembl; ENSSSCT00000048799.3; ENSSSCP00000046027.1; ENSSSCG00000035824.3.
DR VGNC; VGNC:91202; PBRM1.
DR GeneTree; ENSGT00390000003017; -.
DR Proteomes; UP000008227; Chromosome 13.
DR Bgee; ENSSSCG00000035824; Expressed in mesenteric lymph node and 42 other cell types or tissues.
DR GO; GO:0016586; C:RSC-type complex; IEA:InterPro.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR CDD; cd04717; BAH_polybromo; 2.
DR CDD; cd05524; Bromo_polybromo_I; 1.
DR CDD; cd05517; Bromo_polybromo_II; 1.
DR CDD; cd05520; Bromo_polybromo_III; 1.
DR CDD; cd05518; Bromo_polybromo_IV; 1.
DR CDD; cd05515; Bromo_polybromo_V; 1.
DR CDD; cd05526; Bromo_polybromo_VI; 1.
DR CDD; cd21984; HMG-box_PB1; 1.
DR Gene3D; 2.30.30.490; -; 2.
DR Gene3D; 1.20.920.10; Bromodomain-like; 6.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR037968; PBRM1_BD5.
DR InterPro; IPR037382; Rsc/polybromo.
DR PANTHER; PTHR16062:SF19; PROTEIN POLYBROMO-1; 1.
DR PANTHER; PTHR16062; SWI/SNF-RELATED; 1.
DR Pfam; PF01426; BAH; 2.
DR Pfam; PF00439; Bromodomain; 6.
DR Pfam; PF00505; HMG_box; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00439; BAH; 2.
DR SMART; SM00297; BROMO; 6.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47370; Bromodomain; 6.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS51038; BAH; 2.
DR PROSITE; PS00633; BROMODOMAIN_1; 5.
DR PROSITE; PS50014; BROMODOMAIN_2; 6.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 1: Evidence at protein level;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A287APN6};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT DOMAIN 275..345
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 411..481
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 611..681
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 749..819
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 887..957
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 1028..1073
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 1167..1285
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT DOMAIN 1367..1483
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT DOMAIN 1590..1658
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 1590..1658
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 192..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 366..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 698..728
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1113..1152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1317..1344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1565..1589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1642..1671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..215
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1113..1144
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1900 AA; 215509 MW; FA5120B4911CE635 CRC64;
MLGPKPGSDT EIRLKKPYPD LHPWDSAFLL YHGPAVNVGP SNPRMDQGDN LPARPLFPQI
KRHRLIDHQV PLHPPHDPTH SAASYWKLER QCQQLHQRSQ TQCASERATC ELRPLVSVTH
SRSCRKAHRR RRACARTQCR AEPGSLGGRG AGFAAEPGGV RAVRAAGAGA TAAAAAGGAI
AAAVAATGRG AAVGDRGRGC RRRSGWKKLD SMGSKRRRAT SPSSSVSGDF DDGHHSVSTP
GPSRKRRRLS SLPTVDPIAV CHELYNTIRD YKDEQGRLLC ELFIRAPKRR NQPDYYEVVS
QPIDLMKIQQ KLKMEEYDDV NLLTADFQLL FNNAKAYYKP DSPEYKAACK LWDLYLRTRN
EFVQKGEAED EDDDEDGQDN QGTVTEGSSP GYLKEILEQL LEAIVVATNP SGRLISELFQ
KLPSKVQYPD YYAIIKEPID LKTIAQRIQN GSYKSIHAMA KDIDLLAKNA KTYNEPGSQV
FKDANSIKKI FYMKKAEIEH HEITKSSLRM RTSSNLVAAR LTGPSHSKGS LGEERNPTSK
YYRNKRAVQG GRLSAITMAL QYGSESEEDA TLAAARYEEG ESEAESITSF MDVSNPFYQL
YETVRSCRNN QGQLIAEPFF HLPSKKKYPD YYQQIKMPIS LQQIRTKLKN QEYETLDHLE
GDLNLMFENA KRYNVPNSAI YKRVLKLQQV MQAKKKELAR RDDIEDGDSM ISSATSDTGS
AKRKSKKNIR KQRMKILFNV VLEAREPGSG RRLCDLFMVK PSKKDYPDYY KIILEPMDLK
IIEHNIRNDK YAGEEGMIED MKLMFRNARH YNEEGSQVYN DAHILEKLLK DKRKELGPLP
DDDDVASPKL KLSRKSGISP KKSKYMTPMQ QKLNEVYEAV KNYTDKRGRR LSAIFLRLPS
RSELPDYYLT IKKPMDMEKI RSHMMANKYQ DIDSMVEDFV MMFNNACTYN EPESLIYKDA
LVLHKVLLET RRDLEGDEDS HVPNVTLLIQ ELIHNLFVSV MSHQDDEGRC YSDSLAEIPA
VDPNFPNKPP LTFDIIRKNV ENNRYRRLDL FQEHMFEVLE RARRMNRTDS EIYEDAVELQ
QFFIKIRDEL CKNGEILLSP ALSYTTKHLH NDVEKEKKEK LPKEIEEDKL KREEEKREAE
KSEDSSGAAG LSGLHRTYSQ DCSFKNSMYH VGDYVYVEPA EANLQPHIVC IERLWEDSAG
EKWLYGCWFY RPNETFHLAT RKFLEKEVFK SDYYNKVPVS KILGKCVVMF VKEYFKLCPE
NFRDEDVFVC ESRYSAKTKS FKKIKLWTMP ISSVRFVPRD VPLPVVRVAS VFANADKGDD
EKNTDNSEDS RTEDSFNLEK EKEDVPVEMS NGEPGCHYFE QLRYNDMWLK VGDCVFIKSH
GLVRPRVGRI EKVWVRDGAA YFFGPIFIHP EETEHEPTKM FYKKEVFLSN LEETCPMTCI
LGKCAVLSFK DFLSCRPTEI PENDILLCES RYNESDKQMK KFKGLKRFSL SAKVVDDEIY
YFRKPIVPQK EPSPLLEKKI QLLEAKFAEL EGGDDDIEEM GEEDSEVIEP PSLPQLQTPL
ASELDLMPYT PPQSTPKSAK GSAKKEGSKR KINMSGYILF SSEMRAVIKA QHPDYSFGEL
SRLVGTEWRN LETAKKAEYE ERAAKVAEQQ ERERAAQQQQ PSASPRAGTP VGALMGVVPP
PTPMGMLNQQ LTPVAGMMGG YPPGLPPLQG PVDGLVSMGS MQPLHPGGPP PHHLPPGVPG
LSGIPPPGVM NQGVAPMVGT PAPGGSPYGQ QVGVLGPPGQ QAPPPYPGPH PTGPPVIQQP
TTPMFVAPPP KTQRLLHSEA YLKYIEGLSA ESNSISKWDQ TLAARRRDVH LSKEQESRLP
SHWLKSKGAH TTMADALWRL RDLMLRDTLN IRQAYNLENL
//
