ID A0A287ARB4_PIG Unreviewed; 1742 AA.
AC A0A287ARB4; A0A8D0Z5A6;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Myosin VC {ECO:0000313|Ensembl:ENSSSCP00000046609.1};
DE SubName: Full=Unconventional myosin-Vc {ECO:0000313|EMBL:HDB22569.1};
GN Name=MYO5C {ECO:0000313|Ensembl:ENSSSCP00000046609.1,
GN ECO:0000313|VGNC:VGNC:90532};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000046609.1, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000046609.1, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000046609.1,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HDB22569.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000046609.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; DQIR01167092; HDB22569.1; -; Transcribed_RNA.
DR RefSeq; XP_005659654.1; XM_005659597.2.
DR STRING; 9823.ENSSSCP00000046609; -.
DR PaxDb; 9823-ENSSSCP00000004980; -.
DR Ensembl; ENSSSCT00000060339.2; ENSSSCP00000046609.1; ENSSSCG00000004621.5.
DR Ensembl; ENSSSCT00005029558.1; ENSSSCP00005017995.1; ENSSSCG00005018721.1.
DR GeneID; 100155557; -.
DR KEGG; ssc:100155557; -.
DR CTD; 55930; -.
DR VGNC; VGNC:90532; MYO5C.
DR eggNOG; KOG0160; Eukaryota.
DR GeneTree; ENSGT00940000157971; -.
DR OMA; EIMFDDR; -.
DR OrthoDB; 1094820at2759; -.
DR Proteomes; UP000008227; Chromosome 1.
DR Bgee; ENSSSCG00000004621; Expressed in metanephros cortex and 16 other cell types or tissues.
DR GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0031982; C:vesicle; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000146; F:microfilament motor activity; IBA:GO_Central.
DR GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR GO; GO:0030050; P:vesicle transport along actin filament; IBA:GO_Central.
DR CDD; cd15476; Myo5c_CBD; 1.
DR CDD; cd01380; MYSc_Myo5; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 2.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.30.70.1590; -; 1.
DR Gene3D; 6.10.220.10; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR002710; Dilute_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR037991; Myo5c_CBD.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR036103; MYSc_Myo5.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF706; MYOSIN-11; 1.
DR Pfam; PF01843; DIL; 1.
DR Pfam; PF00612; IQ; 4.
DR Pfam; PF00063; Myosin_head; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM01132; DIL; 1.
DR SMART; SM00015; IQ; 5.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51126; DILUTE; 1.
DR PROSITE; PS50096; IQ; 4.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 1: Evidence at protein level;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A287ARB4};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT DOMAIN 8..62
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 67..753
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1421..1697
FT /note="Dilute"
FT /evidence="ECO:0000259|PROSITE:PS51126"
FT REGION 632..654
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT COILED 884..1098
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1211..1351
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 161..168
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1742 AA; 203103 MW; 6A7D065549B2C5F4 CRC64;
MAVAELYTQY NRVWIPDPEE VWKSAEIAKD YKIGDKVLQL LLEDGTELDY SVDPESLPPL
RNPDILVGEN DLTALSYLHE PAVLHNLRIR FAESKLIYTY SGIILVAMNP YKQLPIYGDA
IIHAYSGQNM GDMDPHIFAV AEEAYKQMAR NNKNQSIIVS GESGAGKTVS ARYAMRYFAT
VSKSSSNAHV EDKVLASNPI TEAVGNAKTT RNDNSSRFGK YTEISFDERN QIIGANMRTY
LLEKSRVVFQ SENERNYHIF YQLCASAQQS EFKHLKLASA EEFNYTRMGG STVIEGVNDR
ADMIETQKTF SLLGFKEDFQ MDVFKILAAI LHLGNVEIIA VGNERSAVSE DDSHLKVFCE
LLGLESGKVA QWLCNRKIIT TSETVVKPMT RPQATNARDA LAKKIYAHLF DFIVERINQA
LQFSGKQHTF IGVLDIYGFE TFDVNSFEQF CINYANEKLQ QQFNLHVFKL EQEEYMKEDI
PWTLIDFYDN QPVIDLIEAK MGILELLDEE CLLPHGTDEN WLQKLYNNFI NKNSLFEKPR
MSNTSFIIQH FADKVEYKCE GFLEKNRDTV YDMLVEILRA SKFHLCANFF QENPVLSSPF
GSAITVKSAK PVIKPNNKHF RSTVGSKFRS SLYLLMETLN ATTPHYVRCI KPNDEKLPFE
FDSKRIVQQL RACGVLETIR ISAQSYPSRW TYIEFYSRYG ILMTKQELSF SDKKEVCKVV
LHRLIQDSNQ YQFGKTKIFF RAGQVAYLEK LRLDKLRQGC VVIQKHIRGW LQRKKFLRER
RAALIIQQYF RGQQTVRKAV TATALKEAWA AIIIQKHCRG YLVRNLYQLI RVATITIQAY
TRGFLARRRY RKILEEHKAV ILQKYARAWL ARRRFQNIRR FVLNIQLTYR VQRLQKKLED
QNKENHGLVE KLTSLAALRA SDMEKIQKLE SELDRAATHR QNYEEKGKRY KASMEEKLAK
LQKHNSELEM QKEQIQLKLQ EKTEELKEKM DDLTKQLFED VQKEERQRIL LEKSFELKTR
DYEEQIQTLK EEIKVLKDEK LHLQHQLEEE QAMSEGLKGE VARLSKQAKT ISEFEKEIEL
LQTQKIDVEK HVQSQKREMR EKMSEITKQL LESYDVEDVR SRLSVEDLEH LNEDGELWFA
YEGLKKATRV LESHFQSQKD CYEKEIEALN FKVVHLSQEI NHLQKLFREE NDINESIRHE
VTRLTSENMM IPDFKQQISE LEKQKQDLEI RLNEQTENMK GKLEELSNQL NRNREEEGTQ
RKTIEAQNEI HTKEREKLMD KIQEMQEASE HLKKQFETES EVKSSFRQEA SRLTMENRDL
EEELDMKDRV IKKLQDQVKT LTKTIEKTND VRLSSGPKEY LGMLEYKRED EAKLIQNLIL
DLKPRGVVVN MIPGLPAHIL FMCVRYADSL NDANMLKSLM NSAINGIKQV VKEHLEDFEL
LSFWLSNTCH FLNCLKQYSG EEEFMKHNSP HQNKNCLNNF DLSEYRQILS DVAIRIYHQF
IIVMENNIQP IIVPGMLEYE SLQGISGLKP TGFRKRSSSI DDTDAYTMTS ILQQLSYFYS
TMCQNGLDPE IVRQAVKQLF FLIGAVTLNS LFLRKDMCSC RKGMQIRCNI SYLEEWLKDK
NLQNSLAKET LEPLSQAAWL LQVKKTTDSD AKEIYERCTS LSAVQIIKIL NSYTPIDDFE
KRVTPSFVRK VQALLNSRED SSHLMLDTKY LFQVTFPFTP SPHALEMIQI PSSFKLGFLN
RL
//
