ID A0A287ARP5_PIG Unreviewed; 1858 AA.
AC A0A287ARP5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Fer-1 like family member 6 {ECO:0000313|Ensembl:ENSSSCP00000046758.2};
GN Name=FER1L6 {ECO:0000313|Ensembl:ENSSSCP00000046758.2,
GN ECO:0000313|VGNC:VGNC:88086};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000046758.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000046758.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000046758.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000046758.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR SMR; A0A287ARP5; -.
DR STRING; 9823.ENSSSCP00000046758; -.
DR Ensembl; ENSSSCT00000037221.2; ENSSSCP00000046758.2; ENSSSCG00000033333.2.
DR VGNC; VGNC:88086; FER1L6.
DR GeneTree; ENSGT00940000159069; -.
DR InParanoid; A0A287ARP5; -.
DR Proteomes; UP000008227; Chromosome 4.
DR Bgee; ENSSSCG00000033333; Expressed in colon and 5 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007009; P:plasma membrane organization; IBA:GO_Central.
DR GO; GO:0009617; P:response to bacterium; IEA:Ensembl.
DR CDD; cd04011; C2B_Ferlin; 1.
DR CDD; cd04018; C2C_Ferlin; 1.
DR CDD; cd04017; C2D_Ferlin; 1.
DR CDD; cd04037; C2E_Ferlin; 1.
DR CDD; cd08374; C2F_Ferlin; 1.
DR Gene3D; 2.60.40.150; C2 domain; 5.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037720; C2B_Ferlin.
DR InterPro; IPR037722; C2C_Ferlin.
DR InterPro; IPR037723; C2D_Ferlin.
DR InterPro; IPR037724; C2E_Ferlin.
DR InterPro; IPR037725; C2F_Ferlin.
DR InterPro; IPR012968; FerIin_dom.
DR InterPro; IPR037721; Ferlin.
DR InterPro; IPR012561; Ferlin_B-domain.
DR InterPro; IPR032362; Ferlin_C.
DR PANTHER; PTHR12546; FER-1-LIKE; 1.
DR PANTHER; PTHR12546:SF37; FER-1-LIKE 6 (C. ELEGANS); 1.
DR Pfam; PF00168; C2; 6.
DR Pfam; PF08150; FerB; 1.
DR Pfam; PF08151; FerI; 1.
DR Pfam; PF16165; Ferlin_C; 1.
DR SMART; SM00239; C2; 6.
DR SMART; SM01201; FerB; 1.
DR SMART; SM01202; FerI; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 6.
DR PROSITE; PS50004; C2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1825..1844
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 65..184
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 226..356
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 813..940
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 972..1101
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1339..1458
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1579..1730
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 429..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1139..1204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1227..1248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..450
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1175..1190
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1858 AA; 209125 MW; 4C92607AB3295406 CRC64;
MFGLKLKKKK KKAEKGLILA NKGAQDGQGD VEALQEGPSH QEGLGGDLIY DSASISPVPS
APPKRRAKLL TKIHDGEVRS QNYQIAINIT EARQLVGENI DPVVIIEIGD EKKQSTVKEG
TNSPFYNEYF VFDFTGPQLH LFDKIIKISV FHHKLIGSVL IGSFKVDLGT VYNQPGHQFC
DKWAVLTDPG DIRTGAKGYL KCDISMTGKG DVLKPNPKTS DAEEQIEKNL LIPQGYPSER
PWARFFVRLY RAEGLPKMNS SLMANVTKAF VGDSKDLVDP FVEVSFAGQM GRTTVQKNCA
DPVWHEQVVF KEMFPPLCRR VKIQVWDEGS MNDVTMATHF IDLKKISNEQ DGDKGFLPTF
GPAWINLYGS PRNHSLMDDY QELNEGFGEG VSFRGRILVE IAVEILSGGA QESKFSKALK
ELKLSSKDKD SKSSKSASKE KGDKTDGGRP QQASDKTNST EVEVEPFDVP PEIVPEKYEE
FLLFGAFFEA TMIDRRIGDK PISFEVSIGN FGNFIDGGSH HGSRKKSTDP AEEDSLPLLH
EVEGDAAQEA PMPVVSTTHP EKPLVTEGNR NYSYLPFEAK KPCVYFVSSW GDQTFRLHWS
NMLEKMADLL EEGLEEVKEL IKLSEEAPEE KMKTVLSDFI SQSSTFISEA EKKPKILNQT
NLDKKRLTLC WQELEAVAKE AKELIQQQKK KFSLDEMIQE TQNFVEKIRF LGDEPQHTIP
DVFIWMLSNN KRVAYARIAA KDLLYSPIRE QMGKHCGKIK THFLKLPGKR PSGWSVQAKI
DVYLWLGSTR YSSAILDNLP AGYEAETSSK GAGAHQLPAN LLYQERHVFQ LRAHMYQARG
LIAADSNGLS DPFAKVTFLS HCQTTKVISQ TLSPTWNQML LFNDLVLHGD QKELAESPPS
VVVELYDSDA VGKPEYLGAT VAAPVVKLAD QDYEPPRLCY HPIFCGNLSG GDLLAVFELL
QVPASGLQGL PPLDPPDVTQ IYPVPASIRP VLSKYRVEVL FWGVREMKKV QLLSVDRPQV
LIECGGCGVK SCVIQSYKNN PNFSVQADAF EVELPENELL HPPLSICVVD WRAFGRSTLV
GTYTINCLKQ YLCKSREPLA LASQVDGTQL GQVVSDSFMA TEPSGLSSVQ ELPTDHVFVD
VEPPPTVVPD SAQGQPSSLI DVPDSSPMLE PEHKPAAQEP PKDGKAKDAR KPSRRSTKRR
KRTIADESAE NVIDWWSKYY ASLKKAQKEK ESNSKEKKGS AETKPDEVVV NIDSPKKKKD
KMPKKKLKED EIPNLAVLKI YDGDLESEFN NFEDWVKTFE LLRGKSVEDD HGLDGDRVIG
KFKGSFCIYK SPEASSMEDS GPLRVQQGIP ANHPVPVLIR VYIVAAFNLS PADADGKSDP
YIVIKLGKTE IKDRDKYIPK QLNPVFGRSF EIQATFPKES LLSVLIYDHD MIGTDDLIGE
TRIDLENRFY SKHRAICGLQ SQYEIEGYNA WRDTSKPTEI LTKLCKDNKL DGPYFRPGKI
QIGNQVFSGK TVFTEEDTEE TVESYEHLAL RVLHSWEDIP EVGCRLVPEH IETRPLYHKD
KPGMEQGRLQ MWVDMFPKDM PQPGPPVDIS PRKPKGYELR VIIWNTEDVI LEDENIFTGQ
KSSDIYVKGW LKGLEDDKQE TDVHYNSLTG EGNFNWRFLF PFQYLPAEKQ MVITKRENIF
SLEKMECKTP AVLVLQVWDF ERLSSDDFLG SLEMNLNSFP RAAKSAKACD LTKFENASEE
NKISIFQQKR VRGWWPFSKS KELTGKVEAE FHLVTAEEAE KNPVGKARKE PEPLAKPNRP
DTSFSWFMSP FKCLYHLIWK NYKKYIIIGF ILIILVIFLV LFIYTLPGAI SRRIVVGS
//
