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Database: UniProt
Entry: A0A287ART8_PIG
LinkDB: A0A287ART8_PIG
Original site: A0A287ART8_PIG 
ID   A0A287ART8_PIG          Unreviewed;       483 AA.
AC   A0A287ART8;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2019, sequence version 2.
DT   24-JAN-2024, entry version 32.
DE   RecName: Full=DNA-dependent metalloprotease SPRTN {ECO:0000256|ARBA:ARBA00023885};
DE   AltName: Full=Protein with SprT-like domain at the N terminus {ECO:0000256|ARBA:ARBA00030396};
GN   Name=SPRTN {ECO:0000313|Ensembl:ENSSSCP00000046574.2,
GN   ECO:0000313|VGNC:VGNC:93423};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000046574.2, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000046574.2, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000046574.2,
RC   ECO:0000313|Proteomes:UP000008227};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00000046574.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the Spartan family.
CC       {ECO:0000256|ARBA:ARBA00010724}.
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DR   AlphaFoldDB; A0A287ART8; -.
DR   SMR; A0A287ART8; -.
DR   STRING; 9823.ENSSSCP00000046574; -.
DR   PaxDb; 9823-ENSSSCP00000010851; -.
DR   Ensembl; ENSSSCT00000049185.3; ENSSSCP00000046574.2; ENSSSCG00000040087.3.
DR   VGNC; VGNC:93423; SPRTN.
DR   eggNOG; KOG3931; Eukaryota.
DR   GeneTree; ENSGT00390000003585; -.
DR   InParanoid; A0A287ART8; -.
DR   Reactome; R-SSC-110320; Translesion Synthesis by POLH.
DR   Proteomes; UP000008227; Chromosome 14.
DR   Bgee; ENSSSCG00000040087; Expressed in oocyte and 42 other cell types or tissues.
DR   ExpressionAtlas; A0A287ART8; baseline and differential.
DR   GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR   GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003690; F:double-stranded DNA binding; IEA:Ensembl.
DR   GO; GO:0070530; F:K63-linked polyubiquitin modification-dependent protein binding; IEA:Ensembl.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:Ensembl.
DR   GO; GO:0031593; F:polyubiquitin modification-dependent protein binding; IBA:GO_Central.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:Ensembl.
DR   GO; GO:0043130; F:ubiquitin binding; IEA:Ensembl.
DR   GO; GO:0006974; P:DNA damage response; IBA:GO_Central.
DR   GO; GO:0031398; P:positive regulation of protein ubiquitination; IEA:Ensembl.
DR   GO; GO:0016540; P:protein autoprocessing; IEA:Ensembl.
DR   GO; GO:0106300; P:protein-DNA covalent cross-linking repair; IEA:Ensembl.
DR   GO; GO:0009411; P:response to UV; IEA:Ensembl.
DR   GO; GO:0019985; P:translesion synthesis; IEA:Ensembl.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR   InterPro; IPR006642; Rad18_UBZ4.
DR   InterPro; IPR044245; Spartan.
DR   InterPro; IPR006640; SprT-like_domain.
DR   PANTHER; PTHR21220:SF0; DNA-DEPENDENT METALLOPROTEASE SPRTN; 1.
DR   PANTHER; PTHR21220; UNCHARACTERIZED; 1.
DR   Pfam; PF10263; SprT-like; 1.
DR   SMART; SM00731; SprT; 1.
DR   SMART; SM00734; ZnF_Rad18; 1.
DR   PROSITE; PS51908; ZF_UBZ4; 1.
PE   3: Inferred from homology;
KW   Autocatalytic cleavage {ECO:0000256|ARBA:ARBA00022813};
KW   Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PROSITE-
KW   ProRule:PRU01256};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|PROSITE-
KW   ProRule:PRU01256}; Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU01256}.
FT   DOMAIN          451..478
FT                   /note="UBZ4-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51908"
FT   REGION          216..247
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          288..323
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          347..378
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          423..449
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   483 AA;  54118 MW;  3F5F3D4B67A138BA CRC64;
     MDEDLVLALR LQEEWNLQVS ERNPAQEPLS LVDASWELVD PTPDLQALFV QFNDRFFWGK
     LEAVEVKWSV RMTLCAGICS YEGNGGMCSI RLSEPLLKLR PRKDLVETLL HEMIHAYLFV
     TNNDKDREGH GPEFCKHMHR INRLTGANIT VYHTFHDEVD EYRRHWWRCN GPCQYKKPYF
     GYVKRATNRA PSAHDYWWAE HQKNCGGTFI KIKEPENYSK KGKGKTKPGT QPVSAAEPED
     KPNRSKTQLL IPFSGKGYVL GETSNSPSSG KWITSHAVNK TQDLFSQDQS ANALRSNSKT
     AVKFEQNGSS KKTSLVPSVP SSKHQNVLSS YFPRVTVANQ KAFRSVTGSP AKSLTVGDIT
     KNSAPSSSQR RVTSSKVSLR ESFKAVESTS VTVPPGDQCP GKRPRLEDRA AFDNFFVKKN
     QIQSGGNDPK CPSHLPAATP NPSSSSSWSR TVNCPVCQSE VLEFHINEHL DRCLEGDSTQ
     GKS
//
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