ID A0A287ART8_PIG Unreviewed; 483 AA.
AC A0A287ART8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=DNA-dependent metalloprotease SPRTN {ECO:0000256|ARBA:ARBA00023885};
DE AltName: Full=Protein with SprT-like domain at the N terminus {ECO:0000256|ARBA:ARBA00030396};
GN Name=SPRTN {ECO:0000313|Ensembl:ENSSSCP00000046574.2,
GN ECO:0000313|VGNC:VGNC:93423};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000046574.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000046574.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000046574.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000046574.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the Spartan family.
CC {ECO:0000256|ARBA:ARBA00010724}.
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DR AlphaFoldDB; A0A287ART8; -.
DR SMR; A0A287ART8; -.
DR STRING; 9823.ENSSSCP00000046574; -.
DR PaxDb; 9823-ENSSSCP00000010851; -.
DR Ensembl; ENSSSCT00000049185.3; ENSSSCP00000046574.2; ENSSSCG00000040087.3.
DR VGNC; VGNC:93423; SPRTN.
DR eggNOG; KOG3931; Eukaryota.
DR GeneTree; ENSGT00390000003585; -.
DR InParanoid; A0A287ART8; -.
DR Reactome; R-SSC-110320; Translesion Synthesis by POLH.
DR Proteomes; UP000008227; Chromosome 14.
DR Bgee; ENSSSCG00000040087; Expressed in oocyte and 42 other cell types or tissues.
DR ExpressionAtlas; A0A287ART8; baseline and differential.
DR GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003690; F:double-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0070530; F:K63-linked polyubiquitin modification-dependent protein binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:Ensembl.
DR GO; GO:0031593; F:polyubiquitin modification-dependent protein binding; IBA:GO_Central.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0043130; F:ubiquitin binding; IEA:Ensembl.
DR GO; GO:0006974; P:DNA damage response; IBA:GO_Central.
DR GO; GO:0031398; P:positive regulation of protein ubiquitination; IEA:Ensembl.
DR GO; GO:0016540; P:protein autoprocessing; IEA:Ensembl.
DR GO; GO:0106300; P:protein-DNA covalent cross-linking repair; IEA:Ensembl.
DR GO; GO:0009411; P:response to UV; IEA:Ensembl.
DR GO; GO:0019985; P:translesion synthesis; IEA:Ensembl.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR InterPro; IPR006642; Rad18_UBZ4.
DR InterPro; IPR044245; Spartan.
DR InterPro; IPR006640; SprT-like_domain.
DR PANTHER; PTHR21220:SF0; DNA-DEPENDENT METALLOPROTEASE SPRTN; 1.
DR PANTHER; PTHR21220; UNCHARACTERIZED; 1.
DR Pfam; PF10263; SprT-like; 1.
DR SMART; SM00731; SprT; 1.
DR SMART; SM00734; ZnF_Rad18; 1.
DR PROSITE; PS51908; ZF_UBZ4; 1.
PE 3: Inferred from homology;
KW Autocatalytic cleavage {ECO:0000256|ARBA:ARBA00022813};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PROSITE-
KW ProRule:PRU01256};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|PROSITE-
KW ProRule:PRU01256}; Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU01256}.
FT DOMAIN 451..478
FT /note="UBZ4-type"
FT /evidence="ECO:0000259|PROSITE:PS51908"
FT REGION 216..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 288..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 347..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 483 AA; 54118 MW; 3F5F3D4B67A138BA CRC64;
MDEDLVLALR LQEEWNLQVS ERNPAQEPLS LVDASWELVD PTPDLQALFV QFNDRFFWGK
LEAVEVKWSV RMTLCAGICS YEGNGGMCSI RLSEPLLKLR PRKDLVETLL HEMIHAYLFV
TNNDKDREGH GPEFCKHMHR INRLTGANIT VYHTFHDEVD EYRRHWWRCN GPCQYKKPYF
GYVKRATNRA PSAHDYWWAE HQKNCGGTFI KIKEPENYSK KGKGKTKPGT QPVSAAEPED
KPNRSKTQLL IPFSGKGYVL GETSNSPSSG KWITSHAVNK TQDLFSQDQS ANALRSNSKT
AVKFEQNGSS KKTSLVPSVP SSKHQNVLSS YFPRVTVANQ KAFRSVTGSP AKSLTVGDIT
KNSAPSSSQR RVTSSKVSLR ESFKAVESTS VTVPPGDQCP GKRPRLEDRA AFDNFFVKKN
QIQSGGNDPK CPSHLPAATP NPSSSSSWSR TVNCPVCQSE VLEFHINEHL DRCLEGDSTQ
GKS
//