ID   A0A287AS86_PIG          Unreviewed;       715 AA.
AC   A0A287AS86;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2022, sequence version 3.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=Myotubularin-related protein 12 {ECO:0000256|ARBA:ARBA00018495};
DE   AltName: Full=Inactive phosphatidylinositol 3-phosphatase 12 {ECO:0000256|ARBA:ARBA00033343};
GN   Name=MTMR12 {ECO:0000313|Ensembl:ENSSSCP00000046826.3,
GN   ECO:0000313|VGNC:VGNC:90459};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000046826.3, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000046826.3, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000046826.3,
RC   ECO:0000313|Proteomes:UP000008227};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00000046826.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere
CC       {ECO:0000256|ARBA:ARBA00004204}. Sarcoplasmic reticulum
CC       {ECO:0000256|ARBA:ARBA00004369}.
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC       receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR   AlphaFoldDB; A0A287AS86; -.
DR   STRING; 9823.ENSSSCP00000046826; -.
DR   Ensembl; ENSSSCT00000064358.3; ENSSSCP00000046826.3; ENSSSCG00000031509.3.
DR   VGNC; VGNC:90459; MTMR12.
DR   eggNOG; KOG1089; Eukaryota.
DR   GeneTree; ENSGT00940000160263; -.
DR   InParanoid; A0A287AS86; -.
DR   Reactome; R-SSC-1660516; Synthesis of PIPs at the early endosome membrane.
DR   Proteomes; UP000008227; Chromosome 16.
DR   Bgee; ENSSSCG00000031509; Expressed in oocyte and 42 other cell types or tissues.
DR   ExpressionAtlas; A0A287AS86; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0030017; C:sarcomere; IEA:UniProtKB-SubCell.
DR   GO; GO:0016529; C:sarcoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   CDD; cd14594; PTP-MTMR12; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR022587; MTMR12-like_C.
DR   InterPro; IPR030576; MTMR12_PTP.
DR   InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR   InterPro; IPR030564; Myotubularin_fam.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR   PANTHER; PTHR10807:SF37; MYOTUBULARIN-RELATED PROTEIN 12; 1.
DR   Pfam; PF12578; 3-PAP; 1.
DR   Pfam; PF06602; Myotub-related; 1.
DR   SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW   Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951}.
FT   DOMAIN          173..611
FT                   /note="Myotubularin phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS51339"
FT   REGION          516..538
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   715 AA;  82639 MW;  55D78EE45ABE0D13 CRC64;
     MLGKGVVGGG GGTKAPKPSF VSYVRPEEIH TNEKEVTEKE VTLHLLPGEQ LLCEASTVLK
     CVQEDSCQRG IYGRLVCTDF KISFLGDDES ALDNDETQFK NKVVGENDIT LHCVDQIYGV
     FDEKKKTLFG QLKKYPETLI IHCKDLRVFH FCLRYTKEEE VKRTDRKNHA VMFDTLQDWC
     WELERTKGNM KYKAVSVNEG YKVCERLPAY FVVPTPLPEE DVPRFQGHGI PIWCWSCHNG
     CALLKMSALP KEQDDGILQI QKNFLDGIYK IIHRPPYEIV KTEDLSSNFL SLQEIQTAYS
     KFKQLFLIDN STEFWDTDIK WFSLLESSSW LDIIRRCLKK AIEIIECLEA QNMNILLLEE
     NASDLCCLVS SLVQVMMDPH CRTRFGFQSL VQKEWIMGGH CFLDRCNHLR QSDKEEVPVF
     LLFLDCVWQL VHQHPPAFEF TETYLTVLSD SLYIPIFSTF FFNSPHQKDT NMGRESQDTQ
     GKPLNLLTVW DWSVQFEPKA QTLLKNPLYV EKPKLDKGQR KGTHLKHQRQ LSLPLTQSKS
     SPKRGFFREE TDHLIKNLLG KRISKLINSS EELQDNFREF YDSWHSKPPS YHGLLLPHIE
     GPEVKVWAQR YLRWIPEAQI LGGGRVATMS KLLEMLEEVQ SLQEKIEERH HSQEALQAEA
     TSLLRNSARL SSLFPFALLQ RHSSKPVLPT SGWKALEDEE DLAKREDEFV DLGDV
//