GenomeNet

Database: UniProt
Entry: A0A287AVH0_PIG
LinkDB: A0A287AVH0_PIG
Original site: A0A287AVH0_PIG 
ID   A0A287AVH0_PIG          Unreviewed;       341 AA.
AC   A0A287AVH0;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   03-JUL-2019, entry version 16.
DE   SubName: Full=Cyclic AMP-responsive element-binding protein 1 isoform B {ECO:0000313|EMBL:HCZ77211.1};
GN   Name=CREB1 {ECO:0000313|Ensembl:ENSSSCP00000047913};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC   Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000047913, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000047913, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000047913,
RC   ECO:0000313|Proteomes:UP000008227};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00000047913}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2017) to UniProtKB.
RN   [3] {ECO:0000313|EMBL:HCZ77211.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=30723633; DOI=.7717/peerj.6374;
RA   Gilbert D.G.;
RT   "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL   PeerJ 7:E6374-E6374(2019).
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DR   EMBL; AEMK02000100; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DQIR01021736; HCZ77211.1; -; Transcribed_RNA.
DR   SMR; A0A287AVH0; -.
DR   Ensembl; ENSSSCT00000045029; ENSSSCP00000047913; ENSSSCG00000034395.
DR   GeneTree; ENSGT00940000155408; -.
DR   Reactome; R-SSC-198693; AKT phosphorylates targets in the nucleus.
DR   Reactome; R-SSC-199920; CREB phosphorylation.
DR   Reactome; R-SSC-375165; NCAM signaling for neurite out-growth.
DR   Reactome; R-SSC-442742; CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling.
DR   Reactome; R-SSC-881907; Gastrin-CREB signalling pathway via PKC and MAPK.
DR   Reactome; R-SSC-9634638; Estrogen-dependent nuclear events downstream of ESR-membrane signaling.
DR   Proteomes; UP000008227; Chromosome 15.
DR   ExpressionAtlas; A0A287AVH0; differential.
DR   GO; GO:1990589; C:ATF4-CREB1 transcription factor complex; IEA:Ensembl.
DR   GO; GO:0005719; C:nuclear euchromatin; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0035497; F:cAMP response element binding; IEA:Ensembl.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0001102; F:RNA polymerase II activating transcription factor binding; IEA:Ensembl.
DR   GO; GO:0000980; F:RNA polymerase II distal enhancer sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0007409; P:axonogenesis; IEA:Ensembl.
DR   GO; GO:0035729; P:cellular response to hepatocyte growth factor stimulus; IEA:Ensembl.
DR   GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
DR   GO; GO:0071300; P:cellular response to retinoic acid; IEA:Ensembl.
DR   GO; GO:0071294; P:cellular response to zinc ion; IEA:Ensembl.
DR   GO; GO:0007623; P:circadian rhythm; IEA:Ensembl.
DR   GO; GO:0007595; P:lactation; IEA:Ensembl.
DR   GO; GO:0060430; P:lung saccule development; IEA:Ensembl.
DR   GO; GO:0007613; P:memory; IEA:Ensembl.
DR   GO; GO:0010944; P:negative regulation of transcription by competitive promoter binding; IEA:Ensembl.
DR   GO; GO:0021983; P:pituitary gland development; IEA:Ensembl.
DR   GO; GO:0055025; P:positive regulation of cardiac muscle tissue development; IEA:Ensembl.
DR   GO; GO:0045600; P:positive regulation of fat cell differentiation; IEA:Ensembl.
DR   GO; GO:0046887; P:positive regulation of hormone secretion; IEA:Ensembl.
DR   GO; GO:0046889; P:positive regulation of lipid biosynthetic process; IEA:Ensembl.
DR   GO; GO:0040018; P:positive regulation of multicellular organism growth; IEA:Ensembl.
DR   GO; GO:0045672; P:positive regulation of osteoclast differentiation; IEA:Ensembl.
DR   GO; GO:0006468; P:protein phosphorylation; IEA:Ensembl.
DR   GO; GO:0050821; P:protein stabilization; IEA:Ensembl.
DR   GO; GO:0008361; P:regulation of cell size; IEA:Ensembl.
DR   GO; GO:0042493; P:response to drug; IEA:Ensembl.
DR   GO; GO:0033762; P:response to glucagon; IEA:Ensembl.
DR   GO; GO:0033363; P:secretory granule organization; IEA:Ensembl.
DR   GO; GO:0060509; P:type I pneumocyte differentiation; IEA:Ensembl.
DR   InterPro; IPR004827; bZIP.
DR   InterPro; IPR003102; Coactivator_CBP_pKID.
DR   InterPro; IPR029802; CREB1.
DR   InterPro; IPR001630; Leuzip_CREB.
DR   PANTHER; PTHR45879:SF1; PTHR45879:SF1; 1.
DR   Pfam; PF00170; bZIP_1; 1.
DR   Pfam; PF02173; pKID; 1.
DR   PRINTS; PR00041; LEUZIPPRCREB.
DR   SMART; SM00338; BRLZ; 1.
DR   PROSITE; PS50217; BZIP; 1.
DR   PROSITE; PS00036; BZIP_BASIC; 1.
DR   PROSITE; PS50953; KID; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008227};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A287AVH0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT   DOMAIN      101    160       KID. {ECO:0000259|PROSITE:PS50953}.
FT   DOMAIN      283    334       BZIP. {ECO:0000259|PROSITE:PS50217}.
FT   REGION        1     26       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A287AVH0}.
FT   REGION      139    165       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A287AVH0}.
FT   COILED      301    335       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   341 AA;  36688 MW;  D5E989AE40BF69AF CRC64;
     MTMESGAENQ QSGDAAVTEA ENQQMTVQAQ PQIATLAQVS MPAAHATSSA PTVTLVQLPN
     GQTVQVHGVI QAAQPSVIQS PQVQTVQSSC KDLKRLFSGT QISTIAESED SQESVDSVTD
     SQKRREILSR RPSYRKILND LSSDAPGVPR IEEEKSEEET SAPAITTVTV PTPIYQTSSG
     QYIAITQGGA IQLANNGTDG VQGLQTLTMT NAAATQPGTT ILQYAQTTDG QQILVPSNQV
     VVQAASGDVQ TYQIRTAPTS TIAPGVVMAS SPALPTQPAE EAARKREVRL MKNREAAREC
     RRKKKEYVKC LENRVAVLEN QNKTLIEELK ALKDLYCHKS D
//
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