ID A0A287AVP1_PIG Unreviewed; 910 AA.
AC A0A287AVP1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 2.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Integrin subunit alpha E {ECO:0000313|Ensembl:ENSSSCP00000048204.2};
GN Name=ITGAE {ECO:0000313|Ensembl:ENSSSCP00000048204.2,
GN ECO:0000313|VGNC:VGNC:89239};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000048204.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000048204.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000048204.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000048204.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR AlphaFoldDB; A0A287AVP1; -.
DR Ensembl; ENSSSCT00000062926.3; ENSSSCP00000048204.2; ENSSSCG00000017869.6.
DR VGNC; VGNC:89239; ITGAE.
DR GeneTree; ENSGT00940000161532; -.
DR Proteomes; UP000008227; Chromosome 12.
DR Bgee; ENSSSCG00000017869; Expressed in ileum and 45 other cell types or tissues.
DR ExpressionAtlas; A0A287AVP1; baseline and differential.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF79; INTEGRIN ALPHA-E; 1.
DR Pfam; PF01839; FG-GAP; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 4.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 853..878
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT DOMAIN 1..155
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 163..215
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 270..330
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 333..397
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 405..465
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 910 AA; 100337 MW; C4F7571EB21BC8DC CRC64;
MMRNIYEKCF ECSFALVQYG SVIQTELDLQ DSQDVAASLD RVQNITQVGS VTKTASAMQH
VLDNIFTPSH GSKAKASKVM VVLTDGDIFD DPLNLTTVIN SPKMQGVERF AIGVGGAFNK
SNTYNELKLI ASDPDEDHAF KVTNYMALDG LLSKLQQRII RVEGMVGDAP HYQLAQVGFS
AQILDEGQVL LGAVGAFDWS GGVLLYDTHS RRGRFLNQTV EDARGAQYSY LGYSVAVLHK
TCGLSYVAGA PRHKQRGAVF ELQKESRETD FALVLEGEQM GSYFGSELCP VDVDMDGITD
LLLVAAPFHH IQGEEGRVSV YRVNHQDGSF TLARTLSGHS RLPYARFGFA MATVGDISQD
QLTDVAIGAP LEDFGADDGA GFGSVYIYNG HSTNQLVDLS THQPQRIRAS AVAPGLHYFG
MSVAGGLDFS GDGLADITVG ALGRAAVLRA RPVVRLKVSM TFIPEALPIG FHGGVKVHLC
FERRSGTTVA ESGLGETSLN FTLDVDAMKQ RKRMQCSDER QCQSSLRKWG AGPQLCEPFL
LLPTEKQLPY EKACKNKLFC IAELQLDTTL SQRALVVGLT KELTMNISLT NSGEDSYMTS
MALNYPRNLQ FKRIQKPPSP NIQCDDPKPE ASVLVMNCAI GHPILKRSSA MFSLVWQLEE
SAFPDRTANI SVSITNYNEN RSSVSKTHSL WFKHAFIAVL PKPSVMYLNT SQALSYHREF
LFDIYGENPF GAKFQLQICV PVKLQGFQLI RVKNLTKTQA DTVCTQKQEP ACGSNPVERV
EEWHSVSCDI TSDKENVTVS AELSLSQSEQ FRRDVTELAI LGEISFNKSL YEGLNAENHK
TKITVIFLKD EEVYSLSLII QSSVGGLLVL IVVIAILVKC GFFKRKYQQL NLDSMRQSQL
KSDSLLEEEN
//
