ID A0A287AVP7_PIG Unreviewed; 658 AA.
AC A0A287AVP7;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 2.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Potassium voltage-gated channel subfamily KQT member 1 {ECO:0000256|ARBA:ARBA00019342};
DE AltName: Full=IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1 {ECO:0000256|ARBA:ARBA00032659};
DE AltName: Full=KQT-like 1 {ECO:0000256|ARBA:ARBA00029687};
DE AltName: Full=Voltage-gated potassium channel subunit Kv7.1 {ECO:0000256|ARBA:ARBA00030121};
GN Name=KCNQ1 {ECO:0000313|Ensembl:ENSSSCP00000048195.2,
GN ECO:0000313|VGNC:VGNC:99782};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000048195.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000048195.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000048195.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000048195.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004187}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004156}. Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004124}. Membrane raft
CC {ECO:0000256|ARBA:ARBA00004285}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the potassium channel family. KQT (TC 1.A.1.15)
CC subfamily. Kv7.1/KCNQ1 sub-subfamily. {ECO:0000256|ARBA:ARBA00009499}.
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DR AlphaFoldDB; A0A287AVP7; -.
DR STRING; 9823.ENSSSCP00000048195; -.
DR Ensembl; ENSSSCT00000059171.3; ENSSSCP00000048195.2; ENSSSCG00000039556.3.
DR VGNC; VGNC:99782; KCNQ1.
DR GeneTree; ENSGT00940000161001; -.
DR Proteomes; UP000008227; Chromosome 2.
DR Bgee; ENSSSCG00000039556; Expressed in granulosa cell and 29 other cell types or tissues.
DR ExpressionAtlas; A0A287AVP7; baseline and differential.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 6.10.140.1910; -; 2.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR InterPro; IPR005827; K_chnl_volt-dep_KCQN1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR47735:SF6; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 1; 1.
DR PANTHER; PTHR47735; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF03520; KCNQ_channel; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01460; KCNQ1CHANNEL.
DR PRINTS; PR01459; KCNQCHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 3: Inferred from homology;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 121..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 146..171
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 198..221
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 260..282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..313
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 325..351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 122..356
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 502..562
FT /note="Potassium channel voltage dependent KCNQ C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03520"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 658 AA; 71885 MW; 8BF58B308FA177BD CRC64;
MAAATSPPRA ERKRWGGGRL PGARRGSAGL AKKCPFSLEL AEGGPTGGAL YAPIGPPGVP
GPSSPAAPAA SPAAADLGPR PRVSLDPRVS IYSARRPLLA RTHIQGRVYN FLERPTGWKC
FVYHFAVFLI VLVCLIFSVL STIEQYVALA TGTLFWMEIV LVVFFGTEYA VRLWSAGCRS
KYVGIWGRLR FARKPISIID LIVVVASMVV LCVGSKGQVF ATSAIRGIRF LQILRMLHVD
RQGGTWRLLG SVVFIHRQEL ITTLYIGFLG LIFSSYFVYL AEKDAVNESG QVEFGSYADA
LWWGVVTVTT IGYGDKVPQT WVGKTIASCF SVFAISFFAL PAGILGSGFA LKVQQKQRQK
HFNRQIPAAA SLIQTAWRCY AAENPDSSTW KIYVRKPSRS QALLSPSPKP KKSVMVKKKK
FKLDKDNGLS PGEKMLAVPQ ITCDLASEEQ RPDHFSVDGC DNSVKKSPTL LEVSTAQFTR
TNSFAEDLDL EGETLLTPIT HVSQLREHHR ATIKVIRRMQ YFVAKKKFQQ ARKPYDVRDV
IEQYSQGHLN LMVRIKELQR RWVQRGQVGR GGGGGAGGGA GAVTQLDQRL ELITDMLQQL
LSLHRGGTPG SRAPGGGGAQ VAQPCSGGSI NPELFLPSNA LPTYEQLTVP GRGPEEGS
//
