ID A0A287AY46_PIG Unreviewed; 381 AA.
AC A0A287AY46;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 3.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=X-box-binding protein 1 {ECO:0000256|ARBA:ARBA00040165};
GN Name=XBP1 {ECO:0000313|Ensembl:ENSSSCP00000048871.3,
GN ECO:0000313|VGNC:VGNC:94993};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000048871.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000048871.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000048871.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000048871.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A287AY46; -.
DR STRING; 9823.ENSSSCP00000048871; -.
DR PaxDb; 9823-ENSSSCP00000030251; -.
DR Ensembl; ENSSSCT00000047245.3; ENSSSCP00000048871.3; ENSSSCG00000030996.4.
DR VGNC; VGNC:94993; XBP1.
DR GeneTree; ENSGT00390000017751; -.
DR InParanoid; A0A287AY46; -.
DR Proteomes; UP000008227; Chromosome 14.
DR Bgee; ENSSSCG00000030996; Expressed in endocardial endothelium and 42 other cell types or tissues.
DR ExpressionAtlas; A0A287AY46; baseline and differential.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IEA:Ensembl.
DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
DR GO; GO:1902236; P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:1900103; P:positive regulation of endoplasmic reticulum unfolded protein response; IEA:Ensembl.
DR GO; GO:0002639; P:positive regulation of immunoglobulin production; IEA:Ensembl.
DR GO; GO:0045348; P:positive regulation of MHC class II biosynthetic process; IEA:Ensembl.
DR GO; GO:1900100; P:positive regulation of plasma cell differentiation; IEA:Ensembl.
DR GO; GO:0045582; P:positive regulation of T cell differentiation; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0035470; P:positive regulation of vascular wound healing; IEA:Ensembl.
DR CDD; cd14691; bZIP_XBP1; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR PANTHER; PTHR46542:SF2; BZIP DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46542; X-BOX BINDING PROTEIN 1; 1.
DR Pfam; PF07716; bZIP_2; 1.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF57959; Leucine zipper domain; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 72..135
FT /note="BZIP"
FT /evidence="ECO:0000259|PROSITE:PS50217"
FT REGION 40..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 222..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 83..124
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 381 AA; 40678 MW; 0B58D505BD4855BF CRC64;
MVVVAAAQSP AAGAPKVLLL SGKPAAAAAA GAPAGRALPI MVPGQRGASP EAASGGPPQT
RKRQRLTHLS PEEKALRRKL KNRVAAQTAR DRKKARMSEL EQQVVDLEEE NQKLLLENQL
LREKTHGLVV ENQELRQRLG MDALVTEEEA ETKGNGAGPV AGSAESAALR LRAGPVVTPP
EHLPMDSDGV DSSDSESDIL LGILFNLDPV MFFRCPSPDS ASLEQLPEVD PEGPSSLPAS
PSSSLGTSPA KLEAINEVIR FDHVYTKPLV LEIPSETESQ ANVVVKIEEA PSSPSEKDRP
EFTVSVKEEL TEDDFIPELG ISDLLSTSHC LKPSSCLLDA YSDCSYEGSP SPLSDMSSLL
GVDHSWEDTF ASELFPQLIS V
//
