ID A0A287AYX8_PIG Unreviewed; 1292 AA.
AC A0A287AYX8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Zinc finger protein 423 {ECO:0000313|EMBL:HDB78031.1, ECO:0000313|Ensembl:ENSSSCP00000049158.1};
GN Name=ZNF423 {ECO:0000313|Ensembl:ENSSSCP00000049158.1,
GN ECO:0000313|VGNC:VGNC:98752};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000049158.1, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000049158.1, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000049158.1,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HDB78031.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000049158.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; DQIR01222554; HDB78031.1; -; Transcribed_RNA.
DR STRING; 9823.ENSSSCP00000049158; -.
DR Ensembl; ENSSSCT00000038482.3; ENSSSCP00000049158.1; ENSSSCG00000002838.5.
DR VGNC; VGNC:98752; ZNF423.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000158492; -.
DR Proteomes; UP000008227; Chromosome 6.
DR Bgee; ENSSSCG00000002838; Expressed in forelimb bud and 38 other cell types or tissues.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0050873; P:brown fat cell differentiation; IEA:Ensembl.
DR GO; GO:0021930; P:cerebellar granule cell precursor proliferation; IEA:Ensembl.
DR GO; GO:0060271; P:cilium assembly; IEA:Ensembl.
DR GO; GO:0120163; P:negative regulation of cold-induced thermogenesis; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:Ensembl.
DR GO; GO:0030513; P:positive regulation of BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0061512; P:protein localization to cilium; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:Ensembl.
DR GO; GO:0050872; P:white fat cell differentiation; IEA:Ensembl.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 12.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24406:SF8; C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR24406; TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED; 1.
DR Pfam; PF00096; zf-C2H2; 5.
DR Pfam; PF13912; zf-C2H2_6; 2.
DR SMART; SM00355; ZnF_C2H2; 30.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 10.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 24.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 23.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 146..173
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 174..201
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 202..229
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 230..257
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 271..299
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 303..331
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 488..516
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 525..548
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 640..662
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 670..692
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 700..724
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 728..756
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 758..786
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 789..816
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 815..838
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 894..921
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 938..965
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 967..994
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1128..1156
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1176..1203
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1206..1233
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1237..1265
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1267..1292
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 1..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 354..406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 598..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1144..1171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..397
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 608..632
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1144..1158
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1292 AA; 145396 MW; D86573F05018D324 CRC64;
MSRRKQAKPR SVKVEEGEAS DFSLAWDSSV TASGGLEGEP ECDRKTSRAL EDRNSVTSQE
ERNEDDEDME DESIYTCDHC QQDFESLADL TDHRAHRCPG DGDDDPQLSW VASSPSSKDV
ASPTQMIGDG CDLGLGEEEG GTGLPYPCQF CDKSFIRLSY LKRHEQIHSD KLPFKCTYCS
RLFKHKRSRD RHIKLHTGDK KYHCHECEAA FSRSDHLKIH LKTHSSSKPF KCTVCKRGFS
STSSLQSHMQ AHKKNKEHLA KSEKEAKKDD FMCDYCEDTF SQTEELEKHV LTRHPQLSEK
ADLQCIHCPE VFVDENALLA HIHQAHANQK HKCPMCPEQF SSVEGVYCHL DSHRQPDSSN
HSVSPDPVLG SVASMSSATP DSSASVERGS TPDSTLKPLR GQKKMREDGQ GWSKVVYSCP
YCSKRDFNSL AVLEIHLKTI HADKPQQSHT CQICLDSMPT LYNLNEHVRK LHKNHAYPVM
QFGNLSAFHC NYCPEMFADI NSLQEHIRVS HCGPNANPPD GNNAFFCNQC SMGFLTESSL
TEHIQQAHCS VGSAKLESPV VQPTQSFMEV YSCPYCTNSP IFGSILKLTK HIKENHKNIP
LAHSKKSKAE QSPVSSDVEV SSPKRQRLSA SANSISNGEY PCNQCDLKFS NFESFQTHLK
LHLELLLRKQ ACPQCKEDFD SQESLLQHLT VHYMTTSTHY VCESCDKQFS SVDDLQKHLL
DMHTFVLYHC TLCQEVFDSK VSIQVHLAVK HSNEKKMYRC TACNWDFRKE ADLQVHVKHS
HLGNPAKAHK CIFCGETFST EVELQCHITT HSKKYNCKFC SKAFHAIILL EKHLREKHCV
FDAATENGTA NGVPPAAAKK AEPADLQGML LKNPEAPNSH EASEDDVDAS EPMYGCDICG
AAYTMEVLLQ NHRLRDHNIR PGEDDGSRKK AEFIKGSHKC NVCSRTFFSE NGLREHLQTH
RGPAKHYMCP ICGERFPSLL TLTEHKVTHS KSLDTGTCRI CKMPLQSEEE FIEHCQMHPD
LRNSLTGFRC VVCMQTVTST LELKIHGTFH MQKLAGSSAA SSPNGQGLQK LYKCALCLKE
FRSKQDLVKL DVNGLPYGLC AGCMARSSNG QVGGLAPPEP ADRPCAGLRC PECSVKFESA
EDLESHVQVD HRDLTPETSG PRKGTQTSPV PRKKTYQCIK CQMTFENERE IQIHVANHMI
EEGINHECKL CNQMFDSPAK LLCHLIEHSF EGMGGTFKCP VCFTVFVQAN KLQQHIFAVH
GQEDKIYDCS QCPQKFFFQT ELQNHTMSQH AQ
//
