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Database: UniProt
Entry: A0A287B0F5_PIG
LinkDB: A0A287B0F5_PIG
Original site: A0A287B0F5_PIG 
ID   A0A287B0F5_PIG          Unreviewed;       788 AA.
AC   A0A287B0F5; A0A4X1V5U1;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 34.
DE   SubName: Full=Adhesion G protein-coupled receptor E5 {ECO:0000313|Ensembl:ENSSSCP00000049898.1};
DE   SubName: Full=CD97 antigen isoform 3 preproprotein {ECO:0000313|EMBL:HDC53587.1};
GN   Name=ADGRE5 {ECO:0000313|Ensembl:ENSSSCP00000049898.1,
GN   ECO:0000313|VGNC:VGNC:85125};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000049898.1, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000049898.1, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000049898.1,
RC   ECO:0000313|Proteomes:UP000008227};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:HDC53587.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=30723633; DOI=.7717/peerj.6374;
RA   Gilbert D.G.;
RT   "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL   PeerJ 7:E6374-E6374(2019).
RN   [3] {ECO:0000313|Ensembl:ENSSSCP00000049898.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; DQIR01298109; HDC53587.1; -; Transcribed_RNA.
DR   Ensembl; ENSSSCT00000051285.3; ENSSSCP00000049898.1; ENSSSCG00000013775.6.
DR   Ensembl; ENSSSCT00005071635.1; ENSSSCP00005044688.1; ENSSSCG00005044404.1.
DR   VGNC; VGNC:85125; ADGRE5.
DR   GeneTree; ENSGT00940000160578; -.
DR   Proteomes; UP000008227; Chromosome 2.
DR   Bgee; ENSSSCG00000013775; Expressed in blood and 41 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR   CDD; cd00054; EGF_CA; 3.
DR   Gene3D; 2.60.220.50; -; 1.
DR   Gene3D; 2.10.25.10; Laminin; 4.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR046338; GAIN_dom_sf.
DR   InterPro; IPR017981; GPCR_2-like_7TM.
DR   InterPro; IPR003056; GPCR_2_ADGRE2_ADGRE5.
DR   InterPro; IPR000832; GPCR_2_secretin-like.
DR   InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR   InterPro; IPR000203; GPS.
DR   PANTHER; PTHR12011:SF348; ADHESION G PROTEIN-COUPLED RECEPTOR E5; 1.
DR   PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR   Pfam; PF00002; 7tm_2; 1.
DR   Pfam; PF07645; EGF_CA; 3.
DR   Pfam; PF01825; GPS; 1.
DR   PRINTS; PR01278; CD97PROTEIN.
DR   PRINTS; PR00249; GPCRSECRETIN.
DR   SMART; SM00181; EGF; 4.
DR   SMART; SM00179; EGF_CA; 3.
DR   SMART; SM00303; GPS; 1.
DR   SUPFAM; SSF57196; EGF/Laminin; 3.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00010; ASX_HYDROXYL; 3.
DR   PROSITE; PS50026; EGF_3; 3.
DR   PROSITE; PS01187; EGF_CA; 2.
DR   PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR   PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR   PROSITE; PS50221; GPS; 1.
PE   1: Evidence at protein level;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW   ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:A0A287B0F5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           27..788
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5040578879"
FT   TRANSMEM        502..521
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        533..550
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        570..591
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        603..626
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        646..668
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        689..712
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        718..741
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          71..110
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          123..166
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          167..206
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          496..742
FT                   /note="G-protein coupled receptors family 2 profile 2"
FT                   /evidence="ECO:0000259|PROSITE:PS50261"
SQ   SEQUENCE   788 AA;  86689 MW;  0D836C29DEBC5753 CRC64;
     MGGPHHGVFL LFHVLCVSLT LSEVGAQSTK ACARWCPLNS SCVNSTACRC NLGFSASSGE
     VFTSPSDSCD DINECAPPTT VSCGKNADCQ NTEGGYHCTC VPGYELASGA PIFRNENENT
     CQDVDECQQK PKICKSRGIC INTQGSYTCQ CPPGFKLNPR DPKLCTDKDE CSSGEHKCHN
     STICTNTVGS YACHCRRGWV PKPGFQNKKN TTVCEEVSFP TWTPPPGIKS QSLSLFFERV
     QNMRRDFKAD LTQKTMKDLI VSLDDLLKTP GDLEALNLSS RHQTATSLLT GLEEILRTLG
     KAFSNDSFTF YSPGGTVLSL VVQEPGSGNI TVGQSHARML LDWAVAAGAG KSDPTVVGIL
     SIPNMQKLLS NSSLDLDLEK KAKLEECYES SVHGAQLRLL SAVNSVFLSN TNTDKLDSPV
     TFAFSHLPGT QEQKEHGPRE ERICAFWKHD GSNGGHWATS GCRILGNGND STTCQCNHLS
     SFAILVAHYN VEDPKLALIT KVGLSLSLVC LLLCILTFLL VRPIQGSRTT VHLHLCICLF
     VGSAIFLAGI ENEGGQVGLR CSLVAGLLHY WFLAAFCWMS LEGMELYFLV VRVFQGQGLR
     KRWLCLIGYG VPLVIVVISA IFAATYKEGY GNALYCWLSH KHGFHWSFQG PVTFIVLCNA
     VIFVTTVWKL TQKFSEINPD IKKLKKARVL TITAIAQLFV LGCTWVFGLL LFDPRSWVLS
     YIFTILNCLQ GFFLFLLYCL LNKKVREEYR KWACMVTRNK YSEFATTTSA SSSSHSQTRA
     LRPSQSGM
//
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