ID A0A287B0F5_PIG Unreviewed; 788 AA.
AC A0A287B0F5; A0A4X1V5U1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE SubName: Full=Adhesion G protein-coupled receptor E5 {ECO:0000313|Ensembl:ENSSSCP00000049898.1};
DE SubName: Full=CD97 antigen isoform 3 preproprotein {ECO:0000313|EMBL:HDC53587.1};
GN Name=ADGRE5 {ECO:0000313|Ensembl:ENSSSCP00000049898.1,
GN ECO:0000313|VGNC:VGNC:85125};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000049898.1, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000049898.1, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000049898.1,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HDC53587.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000049898.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; DQIR01298109; HDC53587.1; -; Transcribed_RNA.
DR Ensembl; ENSSSCT00000051285.3; ENSSSCP00000049898.1; ENSSSCG00000013775.6.
DR Ensembl; ENSSSCT00005071635.1; ENSSSCP00005044688.1; ENSSSCG00005044404.1.
DR VGNC; VGNC:85125; ADGRE5.
DR GeneTree; ENSGT00940000160578; -.
DR Proteomes; UP000008227; Chromosome 2.
DR Bgee; ENSSSCG00000013775; Expressed in blood and 41 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 3.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR003056; GPCR_2_ADGRE2_ADGRE5.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR PANTHER; PTHR12011:SF348; ADHESION G PROTEIN-COUPLED RECEPTOR E5; 1.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF07645; EGF_CA; 3.
DR Pfam; PF01825; GPS; 1.
DR PRINTS; PR01278; CD97PROTEIN.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 3.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 1: Evidence at protein level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A287B0F5};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..788
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040578879"
FT TRANSMEM 502..521
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 533..550
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 570..591
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 603..626
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 646..668
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 689..712
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 718..741
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 71..110
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 123..166
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 167..206
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 496..742
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
SQ SEQUENCE 788 AA; 86689 MW; 0D836C29DEBC5753 CRC64;
MGGPHHGVFL LFHVLCVSLT LSEVGAQSTK ACARWCPLNS SCVNSTACRC NLGFSASSGE
VFTSPSDSCD DINECAPPTT VSCGKNADCQ NTEGGYHCTC VPGYELASGA PIFRNENENT
CQDVDECQQK PKICKSRGIC INTQGSYTCQ CPPGFKLNPR DPKLCTDKDE CSSGEHKCHN
STICTNTVGS YACHCRRGWV PKPGFQNKKN TTVCEEVSFP TWTPPPGIKS QSLSLFFERV
QNMRRDFKAD LTQKTMKDLI VSLDDLLKTP GDLEALNLSS RHQTATSLLT GLEEILRTLG
KAFSNDSFTF YSPGGTVLSL VVQEPGSGNI TVGQSHARML LDWAVAAGAG KSDPTVVGIL
SIPNMQKLLS NSSLDLDLEK KAKLEECYES SVHGAQLRLL SAVNSVFLSN TNTDKLDSPV
TFAFSHLPGT QEQKEHGPRE ERICAFWKHD GSNGGHWATS GCRILGNGND STTCQCNHLS
SFAILVAHYN VEDPKLALIT KVGLSLSLVC LLLCILTFLL VRPIQGSRTT VHLHLCICLF
VGSAIFLAGI ENEGGQVGLR CSLVAGLLHY WFLAAFCWMS LEGMELYFLV VRVFQGQGLR
KRWLCLIGYG VPLVIVVISA IFAATYKEGY GNALYCWLSH KHGFHWSFQG PVTFIVLCNA
VIFVTTVWKL TQKFSEINPD IKKLKKARVL TITAIAQLFV LGCTWVFGLL LFDPRSWVLS
YIFTILNCLQ GFFLFLLYCL LNKKVREEYR KWACMVTRNK YSEFATTTSA SSSSHSQTRA
LRPSQSGM
//