ID A0A287B0L4_PIG Unreviewed; 2967 AA.
AC A0A287B0L4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 2.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Zinc finger ZZ-type and EF-hand domain containing 1 {ECO:0000313|Ensembl:ENSSSCP00000049943.2};
GN Name=ZZEF1 {ECO:0000313|Ensembl:ENSSSCP00000049943.2,
GN ECO:0000313|VGNC:VGNC:95347};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000049943.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000049943.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000049943.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000049943.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 9823.ENSSSCP00000049943; -.
DR PaxDb; 9823-ENSSSCP00000027657; -.
DR Ensembl; ENSSSCT00000052462.3; ENSSSCP00000049943.2; ENSSSCG00000032049.3.
DR VGNC; VGNC:95347; ZZEF1.
DR eggNOG; KOG1426; Eukaryota.
DR GeneTree; ENSGT00940000155045; -.
DR InParanoid; A0A287B0L4; -.
DR Proteomes; UP000008227; Chromosome 12.
DR Bgee; ENSSSCG00000032049; Expressed in duodenum and 41 other cell types or tissues.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0140566; F:histone reader activity; IEA:Ensembl.
DR GO; GO:0070577; F:lysine-acetylated histone binding; IEA:Ensembl.
DR GO; GO:0035064; F:methylated histone binding; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd08667; APC10-ZZEF1; 1.
DR CDD; cd02249; ZZ; 1.
DR CDD; cd02343; ZZ_EF; 1.
DR Gene3D; 3.30.60.90; -; 2.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR InterPro; IPR004939; APC_su10/DOC_dom.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR000433; Znf_ZZ.
DR InterPro; IPR043145; Znf_ZZ_sf.
DR InterPro; IPR040099; ZZEF1.
DR InterPro; IPR047052; ZZEF1_APC10.
DR InterPro; IPR041986; ZZEF1_ZZ.
DR PANTHER; PTHR22772; NOVEL ZZ TYPE ZINC FINGER DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22772:SF4; ZINC FINGER ZZ-TYPE AND EF-HAND DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF03256; ANAPC10; 1.
DR Pfam; PF00569; ZZ; 2.
DR SMART; SM01337; APC10; 1.
DR SMART; SM00054; EFh; 1.
DR SMART; SM00291; ZnF_ZZ; 2.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF57850; RING/U-box; 2.
DR PROSITE; PS51284; DOC; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS01357; ZF_ZZ_1; 1.
DR PROSITE; PS50135; ZF_ZZ_2; 2.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00228}.
FT DOMAIN 111..146
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 226..405
FT /note="DOC"
FT /evidence="ECO:0000259|PROSITE:PS51284"
FT DOMAIN 1778..1833
FT /note="ZZ-type"
FT /evidence="ECO:0000259|PROSITE:PS50135"
FT DOMAIN 1827..1882
FT /note="ZZ-type"
FT /evidence="ECO:0000259|PROSITE:PS50135"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1446..1532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1967..2081
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2427..2461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1450..1464
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1505..1519
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2012..2037
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2062..2076
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2441..2461
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2967 AA; 330549 MW; EA1C22CE7DA53AC6 CRC64;
MGNAPSHSSE DEAGAAGGEG WSPHQDWAAD SGTTPGPGPA APALPPAAAL LEPARLREAA
AALRPTPPCE SLVSRHHGAL LRWLEERLGR GEESVTLEQF REVLEARGAG CSGEQFEEAF
AQFDAEGDGT VDAENMLEAL KNSSGANLQG ELSHIIRQLQ ACSLVPGFID IFSESKEGLD
VHSSMILRFL HRNRLSSTVV PYPMLDHCNN MCTMRASVLK ESLDQLVQKE KESPGDLTRS
PEMDKLKSVA KCYAYIETSS NPADIDKMTN GETSSYWQSD GSARSHWIRL KMKPDVVLRH
LSIAVAATDQ SYMPQQVTVA VGRSASELQE VRDVHIPSNV TGYVTLLENA NISQLYVQIN
IKRCLSDGCD TRIHGLRAVG FQRVKKSGVS VSDASAIWYW SLLTSLVTAS METNPAFAQT
VLRNTQKALQ HMPPLSLSPG STDFSTFLSP NVLEEVDSFL IRITSCCSTP EVELTLLAFA
LARGSVAKVL SSLCTVSDHL DTHYDAASLI SSMASVRQNL LLKYGKPLQL TLQACDVKGK
EEKSGPENLL VEPWTRDGFL TETGKTRAST IFSTGTESAF QVTQIRIMVR RGGIGAQCGL
VFAYNSPSDK FHAEEHFKRF EKYDKWKLQE FRQFVKSRVG CSPDDLGEDD PVGWFELEEE
WDEADVKLQQ CRVAKYLMVK FLCTRQESAE RLGVQGLSIS GYLRPARAEA EQSIVCAHCR
KDAEESVCGA TLLLRTLQFI QQLAHDLVQQ KGSGLKYKSF LDFTGLDLQI FWNFYSKLKE
NPREECVCAQ TLLLQLLQSC FSVLQGDVPA ASEDAKAPRQ SPGQVEAAKE LYAHLCDVVD
RVDGDSVPME LLKQEVRNTL LNGAAIFFPD RQTRRNHLFT MMNVTEQHKQ SLQLTFRSLC
TYFSDKDPGG LLLLPEKGDL ADTDLSEVLA VTRTLLSVAA RECELLMLDG AQGEVGSVLF
SLFWSVQGSL LSWCYLQLKS TYSGAKDLAV DLIEKYVGQF LASMRVILES LLSQYSGKTI
VEKLCNSVFS MAARQLVIFL LDFCTLDISH CTLLREFSAL TELLKELCSD PDGGLNKLDV
ETWQQERPVV LHTWTKESAH NYENNCHEVS VFVSPGATYF EVEFDERCET EKRYDYLEFT
DARGGKTRYD TKVGTDKWPK KVTFKAGPRL QFLFHSDSSN NEWGYKFTVT AYGLPDVAVS
WGLDLQLLVS RLMGRLASQC MALKSVHQLG SNVAIPQAKM ALVLNSPLWK PVFRHQIRPE
LGLEASWPTH PHQDNKEVKN IPDDPCHQFL LDFAQSDPAQ NFCGPYSELF KGFIQACRKQ
APKTDIVAGS TIDQAVNATF AALVYRTPDL YEKLQKYVNS GGKTALSEEF AQVYSLADGI
RIWMLEMKQK SLMSLGNEAE DRRGSEAAEA NPESLAKECI QKSLLLLKFL PIGASSKESC
DTLVTADETD HLQQPRDRRQ RTGSVAGEHF QASGSPTEAA PPAAGDRSPG LGVQLPPPPS
SGPPAADVSS ATAEEPSSPS TPTRRPPFTR GRLRLLSFRS MEEARPAPAV KERYPVLRDV
MDFVKDQALS PESVVKVLSL RKAQACSILE VLRIAQCCSE SLGQPHCFHP PYILFLLELL
TCQKDFTNYF GHLEGCGADL HKEIRDTYYQ FVLFLVKAVK GFGSLNDRSL LPALSCVQTA
LLHLLDMGWE PSDLAFFVDI QLPDLLMNMS QENISVHDSV ISQWSEEDEL ADAKQNSEWM
DECQDGMFEA WYEKIAQEDP EKQRKMHMFI ARYCDLLNVD ISCDGCDEIA PWHRYRCLQC
SDMDLCKTCF LGGVKPEGHG DDHEMVNMEF TCDHCQGLII GRRMNCNVCD DFDLCYGCYA
AKKYSYGHLP THSITAHPMV TIRISDRQRL IQPYIHNYSW LLFAALALYS AHVASAEDVD
GEKLAPQARR SAAALRSRCM QLVGDCLMKA HQGKGLKALA LLGILPDGDS PPENQAPPVT
APTGTAEEQR EKAAAQAAAA PADAGPLAHC SGKRDVPKEV RPLDPKQRSK ADEGVSLMKE
PSCRTQTSDA AADACTPTGL PDAENSEASS QKPMEEKAVT PSPEQVFAEC SQKRILGLLA
AMLPPLNSDP TGPLIDLEHV LPLMFQVVIS NAGHLNETYH LTLGLLGQLI IRLLPAEVDA
AVTKVLSAKH NLFAAGDSSL VPDGWKTTHL LFSLGAVCLD SRVGLDWACS MAEILRSLNS
APLWRDVIAT FTDHCIKQLP FQLKHTNIFT LLVLVGFPQV LCVGTRCVYV DNANEPHNVI
ILKHFTEKNR AVIVDVKTRK RKTVKDYQLI QKGGGQEGSD AQAQLSQYSQ HFAFIASHLL
QTSVDSHCPE AVEATWVLSL ALKGLYKTLK AHGFEETQAT FLQTDLLKLL VKKCSKGTGF
SKTWLLRDLE VLSIMLYSSK KEINTLAEHG ELEPDERGDQ EEDVERSVSS PGEPEQKKLD
PLESLDEPTR ICFLMAHDAL NAPLHILRAI YELQMKRTDS FFLEVQKRFD GDELTTDERI
RTLAQRWQPS RSLRLDEQSA KAVDTDMIIL PCLSRPARCE QATAESNPVT QKLISSTESE
LQQSYAKQRR SKSAALLHKE LNCKSKRAVR DYLFRVNEAT AVLYARHVLA SLLAEWPGHV
PVSEDILELS GPAHMTYILD MFMQLEEKHQ WEKILQKVLQ GCRENMLGTM ALAACQFMEE
PGMEVQVRES KHPYNNNTNF EDKVHIPGAI YLSIKFDPQC NTEEGCDELA MSSSSDFQQD
RHNFSGSQQK WKDFELPGDT LYYRFTSDMS NTEWGYKFTV TAGHLGRFQT GFEILKQMLS
EERVVPHLPL AKIWEWLVGV ACRQTGHQRL KAIHLLLRIV RCCSHSDLCD LTLLKPLWQL
FTQMEYSLFE DVTQPGILLP LHRALTELFF VTENRAQELG LLQDYLLALT TDDHLLRCAA
QALQNIAAIS LAINYPNKAT RLWNVEC
//
