ID A0A287B0V1_PIG Unreviewed; 335 AA.
AC A0A287B0V1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=N-acetylneuraminate synthase {ECO:0000313|Ensembl:ENSSSCP00000050044.2};
GN Name=NANS {ECO:0000313|Ensembl:ENSSSCP00000050044.2,
GN ECO:0000313|VGNC:VGNC:112521};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000050044.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000050044.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000050044.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000050044.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A287B0V1; -.
DR PaxDb; 9823-ENSSSCP00000005766; -.
DR Ensembl; ENSSSCT00000055524.3; ENSSSCP00000050044.2; ENSSSCG00000005373.5.
DR VGNC; VGNC:112521; NANS.
DR eggNOG; ENOG502QTZS; Eukaryota.
DR GeneTree; ENSGT00390000011081; -.
DR Proteomes; UP000008227; Chromosome 1.
DR Bgee; ENSSSCG00000005373; Expressed in hindlimb bud and 44 other cell types or tissues.
DR ExpressionAtlas; A0A287B0V1; baseline and differential.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0047444; F:N-acylneuraminate-9-phosphate synthase activity; IEA:Ensembl.
DR GO; GO:0016051; P:carbohydrate biosynthetic process; IEA:InterPro.
DR CDD; cd11615; SAF_NeuB_like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 3.90.1210.10; Antifreeze-like/N-acetylneuraminic acid synthase C-terminal domain; 1.
DR InterPro; IPR006190; AFP_Neu5c_C.
DR InterPro; IPR036732; AFP_Neu5c_C_sf.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR006013; Antifreeze_III.
DR InterPro; IPR013132; Neu5Ac_N.
DR InterPro; IPR013974; SAF.
DR PANTHER; PTHR42966; N-ACETYLNEURAMINATE SYNTHASE; 1.
DR PANTHER; PTHR42966:SF1; SIALIC ACID SYNTHASE; 1.
DR Pfam; PF03102; NeuB; 1.
DR Pfam; PF08666; SAF; 1.
DR PRINTS; PR00357; ANTIFREEZIII.
DR SMART; SM00858; SAF; 1.
DR SUPFAM; SSF51269; AFP III-like domain; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
DR PROSITE; PS50844; AFP_LIKE; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A287B0V1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..335
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023929313"
FT DOMAIN 270..329
FT /note="AFP-like"
FT /evidence="ECO:0000259|PROSITE:PS50844"
SQ SEQUENCE 335 AA; 37441 MW; 3293F6482316D7BC CRC64;
MVLKDSDLIA VALAFLFSLR ECGADCAKFQ KSELEYKFNR KALERPYTSK HSWGKTYGEH
KRHLEFSHAQ YRELQKFAEE VGIFFTASGM DEMAVEFLHE LNVPFFKVGS GDTNNFPYLE
KTAKKGRPMV ISSGMQSMDT MKQVYQIVKP LNPNFCFLQC TSAYPLQPED VNLRVISEYQ
KLFPDIPIGY SGHETGIAIS VAAVALGAKV LERHITLDKT WKGSDHSASL EPGELAELVR
SVRLVERALG SPTKQLLPCE MACNEKLGKS VVAKVKIPEG TVLTLDMLTV KVGEPKGYPP
EDIFSLVGKK VLVTIEEDDT IMEESVENHG KKIKS
//
