ID A0A287B1V5_PIG Unreviewed; 583 AA.
AC A0A287B1V5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Acyl-CoA thioesterase 11 {ECO:0000313|Ensembl:ENSSSCP00000050388.2};
GN Name=ACOT11 {ECO:0000313|Ensembl:ENSSSCP00000050388.2,
GN ECO:0000313|VGNC:VGNC:85016};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000050388.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000050388.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000050388.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000050388.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=butanoyl-CoA + H2O = butanoate + CoA + H(+);
CC Xref=Rhea:RHEA:40111, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17968, ChEBI:CHEBI:57287, ChEBI:CHEBI:57371;
CC Evidence={ECO:0000256|ARBA:ARBA00000295};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40112;
CC Evidence={ECO:0000256|ARBA:ARBA00000295};
CC -!- PATHWAY: Lipid metabolism; fatty acid metabolism.
CC {ECO:0000256|ARBA:ARBA00004872}.
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DR AlphaFoldDB; A0A287B1V5; -.
DR Ensembl; ENSSSCT00000050621.2; ENSSSCP00000050388.2; ENSSSCG00000037559.3.
DR VGNC; VGNC:85016; ACOT11.
DR GeneTree; ENSGT00940000156460; -.
DR UniPathway; UPA00199; -.
DR Proteomes; UP000008227; Chromosome 6.
DR Bgee; ENSSSCG00000037559; Expressed in heart left ventricle and 41 other cell types or tissues.
DR ExpressionAtlas; A0A287B1V5; baseline and differential.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0016790; F:thiolester hydrolase activity; IEA:InterPro.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd03442; BFIT_BACH; 2.
DR CDD; cd08913; START_STARD14-like; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 2.
DR InterPro; IPR040170; Cytosol_ACT.
DR InterPro; IPR033120; HOTDOG_ACOT.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR InterPro; IPR006683; Thioestr_dom.
DR PANTHER; PTHR11049; ACYL COENZYME A THIOESTER HYDROLASE; 1.
DR PANTHER; PTHR11049:SF1; ACYL-COENZYME A THIOESTERASE 11; 1.
DR Pfam; PF03061; 4HBT; 2.
DR Pfam; PF01852; START; 1.
DR SMART; SM00234; START; 1.
DR SUPFAM; SSF55961; Bet v1-like; 1.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 2.
DR PROSITE; PS51770; HOTDOG_ACOT; 2.
DR PROSITE; PS50848; START; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01106};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine esterase {ECO:0000256|ARBA:ARBA00022487}.
FT DOMAIN 32..144
FT /note="HotDog ACOT-type"
FT /evidence="ECO:0000259|PROSITE:PS51770"
FT DOMAIN 205..318
FT /note="HotDog ACOT-type"
FT /evidence="ECO:0000259|PROSITE:PS51770"
FT DOMAIN 390..563
FT /note="START"
FT /evidence="ECO:0000259|PROSITE:PS50848"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 583 AA; 66307 MW; AB52D38E3C2C90F7 CRC64;
MQGLASVFSN RASKKSAPRS ENNMGDGEGY RNPTEVQMSQ LVLPCHTNQR GELSVGQLLK
WIDATACLSA ERHAGCPCVT ASMDDIYFEH TISVGHVVNI RAKVNRAFNS SMEVGIQVAS
EDLCSEKQWN VCKALATFVA HRELSKVKLK PTTPRTEEEK MEHSVAAERR RMRLVYADTI
KDLLAHYVIH DDLESKDYSR MVPAEKTRVE SVELVLPPHA NHQGNTFGGQ IMAWMENVAT
IAASRLCHAH PTLKAIEMFH FRGPSQVGDR LVLKAIVNNA FKHSMEVGVC VEAYRQEAET
HRRHINSAFM TFVVLDADDQ PQILPWIRPQ PGDGERRYRE ASARKKIRLD RKYIVSCKQA
EMPLSVPWDP SNQVYLSYNN VSSLKMLVAK DNWVLSSEIN QFRVYTLEDD KFLSFHMEML
VQVDAAQAFL LLSDLRRRAE WDKHYRSVEL VQQVDEDDAI YHVISPPIGD DPKPQDFVIL
ASRRKPCDNG DPYVIALRSV TLPTHREMPE YRRGETLCSG FCFWREGDQL TKVSYYNQAT
PGFLNYVTTN VTGLSSEFYT TFKACEQFLL DNRNDLAPSL QAL
//
