ID   A0A287B2D4_PIG          Unreviewed;       705 AA.
AC   A0A287B2D4;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=Integrator complex subunit 11 {ECO:0000256|ARBA:ARBA00016810};
DE   AltName: Full=Cleavage and polyadenylation-specific factor 3-like protein {ECO:0000256|ARBA:ARBA00029625};
GN   Name=INTS11 {ECO:0000313|Ensembl:ENSSSCP00000050317.1,
GN   ECO:0000313|VGNC:VGNC:89159};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000050317.1, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000050317.1, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000050317.1,
RC   ECO:0000313|Proteomes:UP000008227};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00000050317.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily. RNA-
CC       metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.
CC       {ECO:0000256|ARBA:ARBA00007093}.
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DR   AlphaFoldDB; A0A287B2D4; -.
DR   SMR; A0A287B2D4; -.
DR   STRING; 9823.ENSSSCP00000050317; -.
DR   Ensembl; ENSSSCT00000062051.2; ENSSSCP00000050317.1; ENSSSCG00000003339.5.
DR   VGNC; VGNC:89159; INTS11.
DR   GeneTree; ENSGT00940000157644; -.
DR   InParanoid; A0A287B2D4; -.
DR   Reactome; R-SSC-6807505; RNA polymerase II transcribes snRNA genes.
DR   Proteomes; UP000008227; Chromosome 6.
DR   Bgee; ENSSSCG00000003339; Expressed in blood and 43 other cell types or tissues.
DR   ExpressionAtlas; A0A287B2D4; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0032039; C:integrator complex; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0004521; F:RNA endonuclease activity; IBA:GO_Central.
DR   GO; GO:0016180; P:snRNA processing; IBA:GO_Central.
DR   CDD; cd16291; INTS11-like_MBL-fold; 1.
DR   Gene3D; 3.40.50.10890; -; 1.
DR   Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 2.
DR   InterPro; IPR022712; Beta_Casp.
DR   InterPro; IPR041897; INTS11-like_MBL-fold.
DR   InterPro; IPR048662; IntS11_C.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   InterPro; IPR011108; RMMBL.
DR   PANTHER; PTHR11203; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER; 1.
DR   PANTHER; PTHR11203:SF37; INTEGRATOR COMPLEX SUBUNIT 11; 1.
DR   Pfam; PF10996; Beta-Casp; 1.
DR   Pfam; PF21386; IntS11_C; 1.
DR   Pfam; PF16661; Lactamase_B_6; 1.
DR   Pfam; PF07521; RMMBL; 1.
DR   SMART; SM01027; Beta-Casp; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|PeptideAtlas:A0A287B2D4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT   DOMAIN          88..305
FT                   /note="Metallo-beta-lactamase"
FT                   /evidence="ECO:0000259|SMART:SM00849"
FT   DOMAIN          317..435
FT                   /note="Beta-Casp"
FT                   /evidence="ECO:0000259|SMART:SM01027"
FT   REGION          48..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   705 AA;  78186 MW;  7AD76526CB323389 CRC64;
     MAGPEAGGPV GKGLWWPWRL AALPPRVFLL STCGGAVPSA RLHSRHRSAG ALRGSGASGG
     HPSRAGVREG HGSTFPASPC AGAGQDVGRS CILVSIGGKN VMLDCGMHMG FSDDRRFPDF
     SYITRHGRLT DFLDCVIISH FHLDHCGALP YFSEMVGYDG PIYMTQPTQA ICPILLEDYR
     KIAVDKKGEA NFFTSQMIKD CMKKAVAVHL HQTVQVDDEL EIKAYYAGHV LGAAMFQIKV
     GSESVVYTGD YNMTPDRHLG AAWIDKCRPN LLITESTYAT TIRDSKRCRE RDFLKKVHET
     VERGGKVLIP VFALGRAQEL CILLETFWER MDLKAPIYFS TGLTEKANHY YKLFIPWTNQ
     KIRKTFVQRN MFEFKHIKAF DRAFADSPGP MVVFATPGML HAGQSLQIFR KWAGNEKNMV
     IMPGYCVQGT VGHKILSGQR KLELEGRQVV SLRRLCQPQA PLRWVGAPGA SACADGLCAV
     TLQLEVKMQV EYMSFSAHAD AKGIMQLVGQ AEPENVLLVH GEAKKMEFLK QKIEQEFRLS
     CYMPANGETV TLPTSPSIPV GISLGLLKRE MAQGLLPDAK KARLLHGTLI MKDSTFRLVS
     SEQALKELGL AEHQLRFTCR VHLHDPRKEQ EMAMRVYSHL KSLLKDHCVQ HLPDGSVTVE
     SILIQAAAHS EDPGTKVLLV SWTYQDEELG SYLTSLLKKG LPQAP
//