ID A0A287B986_PIG Unreviewed; 845 AA.
AC A0A287B986;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Taste receptor type 1 member 3 {ECO:0000256|ARBA:ARBA00040705};
GN Name=TAS1R3 {ECO:0000313|Ensembl:ENSSSCP00000052899.2,
GN ECO:0000313|VGNC:VGNC:93742};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000052899.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000052899.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000052899.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000052899.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. TAS1R
CC subfamily. {ECO:0000256|ARBA:ARBA00038492}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A287B986; -.
DR Ensembl; ENSSSCT00000047431.3; ENSSSCP00000052899.2; ENSSSCG00000003341.4.
DR VGNC; VGNC:93742; TAS1R3.
DR GeneTree; ENSGT00940000160679; -.
DR Proteomes; UP000008227; Chromosome 6.
DR Bgee; ENSSSCG00000003341; Expressed in endocardial endothelium and 29 other cell types or tissues.
DR ExpressionAtlas; A0A287B986; baseline and differential.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF435; TASTE RECEPTOR TYPE 1 MEMBER 3; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..845
FT /note="Taste receptor type 1 member 3"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023875349"
FT TRANSMEM 566..590
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 602..622
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 678..699
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 725..749
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 761..783
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 789..809
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 566..823
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 845 AA; 92620 MW; 1639758AEBE9DA7D CRC64;
MPGLTLLGLT ALLGLGAGAP LCLSRQLSMQ GHYVLGGLFP LGSTEDAGLG DRTEPNATVC
TRFSSLGLLW ALAMMMAVEE INNGSALLPG LRLGYDLFDT CSEPMVAMKP SLVFMAKAGS
RSIATYCDYT QYQPRVLAVI GPHMSEVALV TGKFFGFFLM PQVSYSASTD RLSNRETFPS
FFRTVPSDRV QAVAMVELLQ ELRWNWVAAV GSDDEYGRQG LSLFSNLANA KGICIAHEGL
VPLPHARSPR LDCTQGLLPQ VNQSSVQVVV LFSSARAARS LFSHSLHCRL SPKVWVASEA
WLTSDLVMTL PGMDQVGTVL GFLHQGALMP EFSAYVQTRL ALAADPAYCA SLAAERQGLE
EHVVGPRCPQ CDYVTLESLS EGLLHHRSFP AYAAVYSVAQ ALHNTLLCNA SGCPTREPVQ
PWQLLENMYN LSFRARGLTL RFDTSGNVDM DYDLKLWVWQ DLMPTLRTVG TFDGRLTLQR
PRMRWHTTGN KEPVSQCSRQ CEEGQVRRVK GFHSCCYDCV DCKAGSYQRN PDDTLCVQCD
QDQWSPDRST RCFPRRPRFL AWGEPAVLVL LVLLGLALGL VLAALGLFIW HRDSPLVQAS
GGPRACFGLA CLGLVCLSVL LFPGRPGPAS CLAQQPLLHL PLTGCLSTLF LQAAEIFARS
ELPPSWADWL CSHLWGPWAW LAVLLAMLAQ AALCTWYLVA FPPEVVTDWR ALPTEALVHC
RVHSWISFSL VHAANATLAF LCFLGTFLVQ SQPGYHNSAR SLTFAMLAYF ITWVSFVPLL
ANVPVASQPA VHMGAALLCV LGILATFHLP KCYLLLRWPE LNTPTFFLGD ARGQGGGEET
LGKNK
//
