ID A0A287BCF4_PIG Unreviewed; 267 AA.
AC A0A287BCF4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Homeobox protein MSX-2 {ECO:0000256|ARBA:ARBA00039539};
GN Name=MSX2 {ECO:0000313|Ensembl:ENSSSCP00000053796.1,
GN ECO:0000313|VGNC:VGNC:90432};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000053796.1, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000053796.1, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000053796.1,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HDB33086.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000053796.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Acts as a transcriptional regulator in bone development.
CC Represses the ALPL promoter activity and antagonizes the stimulatory
CC effect of DLX5 on ALPL expression during osteoblast differentiation.
CC Probable morphogenetic role. May play a role in limb-pattern formation.
CC In osteoblasts, suppresses transcription driven by the osteocalcin FGF
CC response element (OCFRE). Binds to the homeodomain-response element of
CC the ALPL promoter. {ECO:0000256|ARBA:ARBA00037737}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the Msh homeobox family.
CC {ECO:0000256|ARBA:ARBA00038425}.
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DR EMBL; DQIR01177609; HDB33086.1; -; Transcribed_RNA.
DR STRING; 9823.ENSSSCP00000053796; -.
DR Ensembl; ENSSSCT00000050471.3; ENSSSCP00000053796.1; ENSSSCG00000034500.3.
DR VGNC; VGNC:90432; MSX2.
DR GeneTree; ENSGT00940000159824; -.
DR OMA; PVGYNMY; -.
DR OrthoDB; 4848801at2759; -.
DR Proteomes; UP000008227; Chromosome 16.
DR Bgee; ENSSSCG00000034500; Expressed in forelimb bud and 15 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0048598; P:embryonic morphogenesis; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR PANTHER; PTHR24338; HOMEOBOX PROTEIN MSX; 1.
DR PANTHER; PTHR24338:SF10; HOMEOBOX PROTEIN MSX-2; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 140..200
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 142..201
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 1..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 116..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 267 AA; 28968 MW; 16976AD9A0B21BBC CRC64;
MASPSKGNDL FSSDEEGPAM VAGPGPGPGG AEAAVEERRV KVSSLPFSVE ALMSDKKPPK
EASPLPAESA SAGATLRPLL LPGHGAREAH SPGPLVKPFE TASVKSENSE DGAAWMQEPG
RYSPPPRHMS PTTCTLRKHK TNRKPRTPFT TSQLLALERK FRQKQYLSIA ERAEFSSSLN
LTETQVKIWF QNRRAKAKRL QEAELEKLKM AAKPMLPSGF SLPFPINSPL QAASLYGASY
PFHRPVLPIP PVGLYATPVG YGMYHLS
//
