ID A0A287BEQ3_PIG Unreviewed; 1238 AA.
AC A0A287BEQ3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=SET domain bifurcated histone lysine methyltransferase 1 {ECO:0000313|Ensembl:ENSSSCP00000055025.1};
GN Name=SETDB1 {ECO:0000313|Ensembl:ENSSSCP00000055025.1,
GN ECO:0000313|VGNC:VGNC:92764};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000055025.1, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000055025.1, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000055025.1,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000055025.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A287BEQ3; -.
DR Ensembl; ENSSSCT00000064394.3; ENSSSCP00000055025.1; ENSSSCG00000006645.5.
DR VGNC; VGNC:92764; SETDB1.
DR GeneTree; ENSGT00940000157471; -.
DR Proteomes; UP000008227; Chromosome 4.
DR Bgee; ENSSSCG00000006645; Expressed in oocyte and 43 other cell types or tissues.
DR ExpressionAtlas; A0A287BEQ3; baseline and differential.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0140938; F:histone H3 methyltransferase activity; IEA:UniProt.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:UniProt.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd01395; HMT_MBD; 1.
DR CDD; cd10517; SET_SETDB1; 1.
DR CDD; cd20382; Tudor_SETDB1_rpt1; 1.
DR CDD; cd21181; Tudor_SETDB1_rpt2; 1.
DR Gene3D; 2.30.30.140; -; 3.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR040880; DUF5604.
DR InterPro; IPR025796; Hist-Lys_N-MeTrfase_SETDB1.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR007728; Pre-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR047232; SETDB1/2-like_MBD.
DR InterPro; IPR002999; Tudor.
DR InterPro; IPR041292; Tudor_4.
DR InterPro; IPR041291; TUDOR_5.
DR PANTHER; PTHR46024; HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS; 1.
DR PANTHER; PTHR46024:SF2; HISTONE-LYSINE N-METHYLTRANSFERASE SETDB1; 1.
DR Pfam; PF18300; DUF5604; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF05033; Pre-SET; 1.
DR Pfam; PF18358; Tudor_4; 1.
DR Pfam; PF18359; Tudor_5; 1.
DR SMART; SM00391; MBD; 1.
DR SMART; SM00468; PreSET; 1.
DR SMART; SM00333; TUDOR; 2.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50982; MBD; 1.
DR PROSITE; PS50867; PRE_SET; 1.
DR PROSITE; PS51573; SAM_MT43_SUVAR39_1; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 595..666
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT DOMAIN 728..801
FT /note="Pre-SET"
FT /evidence="ECO:0000259|PROSITE:PS50867"
FT DOMAIN 804..1238
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 110..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 405..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 869..1157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 37..64
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 433..450
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 451..472
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 475..538
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..553
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 894..911
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 916..941
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 949..966
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 967..1008
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1035..1054
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1079..1141
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1238 AA; 137142 MW; 5BFEE3BE6B2A015E CRC64;
MSSLPGCIGL DAAAAAMESE EIAELQQAVV EELGISMEEL RQFIDEELEK MDCVQQRKKQ
LAELETWVIQ KESEVAHVDQ LFDDASKAVT NCESLVKDFY SKLGLQYRDS SSEDEASRPT
EIIEIPDEDD DVLSIDSGDA GSRTPKDQKL REAMAALRKS AQDVQKFMDA VNKKSSSQDL
HKGTLSQMTG ELTKDGDLTV GMRILGKKRT KTWHKGTLIA IQTVGPGKKY KVKFDNKGKS
LLSGNHIAYD HHPPVDKLYV GSRVVAKYKD GNQVWLYAGI VAETPNVKNK NRFLIFFDDG
YASYVTESEL YPICRPLKKT WEDIEDISCR DFIEEYITAY PNRPMVLLKS GQLIKTEWEG
TWWKSRVEEV DGSLVRILFL DDKRCEWIYR GSTRLEPMFS MKTSSASALE KKQGGQLRTR
PNMGAVRSKG PVVQYTQDLT STGTQFKPLE PPQPTASPVP PAPAPPGPPL SPQAGDNESL
ESQLAQSRKQ VAKKSTSFRP GSVGSGHSSP TSPALSETAP VGKPGINQTY RSPLGSTTSA
PTPPAPPAPP AFHGMLERAP AEPSYRAPME KLFYLPHVCS YTCLSRVRPM RNEQYRGKNP
LLVPLLYDFR RMTARRRVNR KMGFHVIYKT PCGLCLRTMQ EIERYLFETG CDFLFLEMFC
LDPYVLVDRK FQPYKPFYYI LDITYGKEDV PLSCVNEIDT TPPPQVAYSK ERIPGKGVFI
NTGPEFLVGC DCKDGCRDKS KCACHQLTIQ ATACTPGGQI NPNSGYQYKR LEECLPTGVY
ECNKRCKCDP NMCTNRLVQH GLQVRLQLFK TQNKGWGIRC LDDIAKGSFV CIYAGKILTD
DFADKEGLEM GDEYFANLDH IESVENFKEG YESDAPCSSD SSGVDLKDQE DGNSGTEDPE
ESNDDSSDDN FCKDEDFSTS SVWRSYATRR QTRGQKENGL SEMPSKDSRP PDLGPPHIPV
SPSIPVGSCN PPSSEETPKN KVASWLSCNS VNEGGFADSD SRSSFKTSEG GEGRAGGSRG
EAEKASSSGL GFKDEGDIKQ AKKEDPDDRS KMSIVTESSR NYGYNPSPVK IEGLRRPPSK
TSMHQSRRLL AFAQSNPDDI LTLSSSTESE GESGTSRKPT AGQTSATAVD SDDIQTISSG
SEGDDFEDKK NMSGPVKRQV AVKSTRGFAL KSTHGIAIKS TNMASVEKGE SAPVRKNTRQ
FYDGEESCYI IDAKLEGNLG RYLNENSSWD RTYLGLQL
//