ID A0A287BG55_PIG Unreviewed; 1329 AA.
AC A0A287BG55;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 3.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=KN motif and ankyrin repeat domains 1 {ECO:0000313|Ensembl:ENSSSCP00000055327.3};
GN Name=KANK1 {ECO:0000313|Ensembl:ENSSSCP00000055327.3,
GN ECO:0000313|VGNC:VGNC:103112};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000055327.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000055327.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000055327.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000055327.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 9823.ENSSSCP00000055327; -.
DR Ensembl; ENSSSCT00000060664.3; ENSSSCP00000055327.3; ENSSSCG00000005235.5.
DR VGNC; VGNC:103112; KANK1.
DR GeneTree; ENSGT00940000154886; -.
DR InParanoid; A0A287BG55; -.
DR Proteomes; UP000008227; Chromosome 1.
DR Bgee; ENSSSCG00000005235; Expressed in endocardial endothelium and 42 other cell types or tissues.
DR ExpressionAtlas; A0A287BG55; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0030837; P:negative regulation of actin filament polymerization; IBA:GO_Central.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR047184; KANK1-4.
DR InterPro; IPR021939; KN_motif.
DR PANTHER; PTHR24168; KN MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24168:SF19; KN MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF12075; KN_motif; 1.
DR SMART; SM00248; ANK; 5.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
PE 1: Evidence at protein level;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A287BG55};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 1164..1186
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1236..1268
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1269..1290
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 63..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 918..941
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1004..1057
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 258..312
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 451..485
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 74..99
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1017..1045
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1329 AA; 144803 MW; E4578F5050F837E6 CRC64;
SLGTSISHGC RKADDVLNGD HDREQKDPYF VETPYGYQLD LDFLKYVDDI QKGNTIRKVN
IQKRRKPSVP CPEIRATPSQ QGVWTSTESL SSSNSDDNKQ CPSFLLARSQ VTSTPVPRPL
APLETSPTFL TIPESRQLPP PSPQLPKHNL HVTKTLMETR RRLEQERVTM QIAPSEFRRP
RLASFGGMGS TSSLSSFMGS GNHNNNMYQL QNGYQGNGDY GGYAPAPATT SSMGSSIRHS
PLSSGISTPV TNVSPMHLQH IREQMAIALK RLKELEEQVR TIPVLQVKIS VLQEEKRQLA
SQLKNQRAAS QNDVCGVRKR SYSAGNASQL EQLSRTRRSG GELYIDYEEE EMESVEQSTQ
RIKEFRQLTA DMQALEQKIQ DSSYEASSEV RENGECRPRE CRSVAVGANE NMDDIVVYHR
GARSCKDASV GTVTETRNSG VSVTEAMLGV TTEADKEIEL QQQTIEALKE KIYRLEVQLK
ETTHDREMTK LKQELQAAGS RKKVDKAVMA QPLVFSKMVE AVVLTRDQMT GSHVDVVDTC
VGTCVQTNSL GISCQPDCED KVVGPELPMN WWIVKERVET QDRCSGRSVE MCDKSVGVDI
SVCETGSNTE ESVNDLALLK TNLNLKEVRS IGCGDCSVDV TVSSPKECAS RSVNTEAVSQ
VEAAVMAVPR TMSQHTSTAL EQVNQFTNTE TATLIDSCTN TSLSTSDKQT STWTVEMRTV
AIGEGRVKDV SSAKTRSIGV GTVLSGNAGF DRPSAVKTKE SGVGQISIND NYLVGLKMRT
IACGPPQLTV RLTGSRRSVG VGDEPVGELV ESFQPQALPG TVTGLDHYIE RVQKLLAEQQ
ALLAENYSEL AEAFGEPHSQ IGSLNSQLIS TLSSINSVMK SASAEELRPP DFLKTSLGKV
TGSNLEYTCK CGSLQSRGPL NPQTSQHEQE VGTTEGKPIS GQDTFPPQET TLSAVNLTDD
QIAAGLYVCT NNESTLKSIM KKKDANKDSN GAKKNLQFVG INGGYETTSS DDSSSEESSS
SESDDECDVP DCPPEEEEEE EEDGVTRGMA EGQRAVNVEG FKSTRVEDEM QVPECEPEKV
EIRERYELSE KMLSACNLLK NNINDPRALT SKDMRFCLNT LQHEWFRVSS QKSAIPAMVG
DYIAAFEAIS PDVLRHIINM ADGNGNTALH YSVSHSNFEI VKLLLDADVC NVDHQNKAGY
TPIMLAALAA VEAEKDMQVV EELFGCGDVN AKASQAGQTA LMLAVSHGRI DMVKGLLACG
ADVNIQDDEG STALMCASEH GHVEIVKLLL AQPGCNGHLE DNVSCLCWAS VLGACRSPGL
EGVVSVSAA
//
