ID A0A287BIX9_PIG Unreviewed; 1641 AA.
AC A0A287BIX9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 3.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Roundabout guidance receptor 1 {ECO:0000313|Ensembl:ENSSSCP00000056329.3};
GN Name=ROBO1 {ECO:0000313|Ensembl:ENSSSCP00000056329.3};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000056329.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000056329.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000056329.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000056329.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSSSCT00000058634.3; ENSSSCP00000056329.3; ENSSSCG00000012001.5.
DR GeneTree; ENSGT00940000154477; -.
DR Proteomes; UP000008227; Chromosome 13.
DR Bgee; ENSSSCG00000012001; Expressed in penis and 43 other cell types or tissues.
DR ExpressionAtlas; A0A287BIX9; baseline.
DR GO; GO:0008046; F:axon guidance receptor activity; IEA:InterPro.
DR GO; GO:0016199; P:axon midline choice point recognition; IEA:InterPro.
DR GO; GO:0035385; P:Roundabout signaling pathway; IEA:InterPro.
DR CDD; cd00063; FN3; 3.
DR CDD; cd07693; IgC_1_Robo; 1.
DR CDD; cd05724; IgI_2_Robo; 1.
DR CDD; cd05725; IgI_3_Robo; 1.
DR CDD; cd05726; IgI_4_Robo; 1.
DR CDD; cd20952; IgI_5_Robo; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 8.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR032986; Robo1_Ig-like3.
DR PANTHER; PTHR45080; CONTACTIN 5; 1.
DR PANTHER; PTHR45080:SF32; MYOTILIN; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 3.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 5.
DR SMART; SM00406; IGv; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A287BIX9};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1641
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5036483328"
FT DOMAIN 62..158
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 164..251
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 256..340
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 345..440
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 449..535
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 555..649
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 668..765
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 770..866
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 25..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1118..1162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1174..1320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1356..1377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1403..1610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1118..1149
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1234..1254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1277..1291
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1421..1436
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1499..1522
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1537..1560
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1573..1599
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1641 AA; 179890 MW; C8EE639E06381208 CRC64;
ERWDVAPLSL LLLRKTALVL FPTDPEDLER GKDNGTPIPT SDNDDNSLGY TGSRLRQEDF
PPRIVEHPSD LIVSKGEPAT LNCKAEGRPT PTIEWYKGGE RVETDKDDPR SHRMLLPSGS
LFFLRIVHGR KSRPDEGVYV CVARNYLGEA VSHNASLEVA ILRDDFRQNP SDVMVAVGEP
AVMECQPPRG HPEPTISWKK DGSPLDDKDE RITIRGGKLM ITYTRKSDAG KYVCVGTNMV
GERESEVAEL TVLERPSFVK RPSNLAVTVD DSAEFKCEAR GDPVPTVRWR KDDGELPKSR
YEIRDDHTLK IRKVMAGDMG SYTCVAENMV GKAEASATLT VQEPPHFVVK PRDQVVALGR
TVTFQCEATG NPQPAIFWRR EGSQNLLFSY QPPQSSSRFS VSQTGDLTIT NVQRSDVGYY
ICQTLNVAGS IITKAYLEVT DVIADRPPPV IRQGPVNQTV AVDGTLVLSC VATGSPVPTI
LWRKDGVLVS TQDSRIKQLE TGVLQIRYAK LGDTGRYTCI ASTPSGEATY MDVLSTFMFP
VQPPRPTDPN LIPSAPSKPE VTDVSRNTVT LSWQPNLNSG ATPTSYIIEA FSHASGSSWQ
TVAENVKTET FAIKGLKPNA IYLFLVRAAN AYGISDPSQI SDPVKTQDVP PTSQGVDHKQ
VQRELGNVVL HLHNPTILSS SSIEVHWTVD QQSQYIQGYK ILYRPSGVTH GEAEWLVFEV
RTPTKNSVVI PDLKKGVNYE IKARPFFNEF QGADSEIKFA KTLEEAPSAP PQSVTVSKND
GNGTAILVSW QPPPEDTQNG MVQEYKVWCL GNETRYHINK TVDGSTFSVV IPSLVPGIRY
SVEVAASTGA GAGVKSEPQF IQLDSHGNPV SPEDQVSLAQ QISDVVKQPA FIAGIGAACW
IILMVFSIWL YRHRKKRNGL TSTYAGIRKV TYQRGGEAVS SGGRPGLLNI SEPATQPWLA
DTWPNTGNNH NDCSINCCTA GNGNSDSNLT TYSRPADCIA NYNNQLDNKQ TNLMLPESTV
YGDVDLSNKI NEMKTFNSPN LKDGRFVNPS GQPTPYATTQ LIQSNLSNNM NNGSGDSGEK
HWKPPGQQKQ EVAPIQYNIM EQNKLNKDYR ANDTIPPTIP YNQSYDQNTG GSYNSSDRGS
STSGSQGHKK GARTPKVPKQ GGMNWADLLP PPPAHPPPHS NSEEYSVSVD ESYDQEMPCP
VPPARMYLQQ GELEEEEDER GPTPPVRGAA SSPAAVSYSH QSTATLTPSP QEELQPMLQD
CPEEIGHMQL QTDRRRQPVS PPPPPRPISP PHTYGYISGP LVSDMDTDAP EEEEDEADME
VAKMQTRRLL LRGLEQTPAS SVGDLESSVT GSMINGWGSA SEEDNISSGR SSVSSSDGSF
FTDADFAQAV AAAAEYAGLK VARRQMQDAA GRRHFHASQC PRPTSPVSTD SNMSAAVVQK
ARPAKKQKHQ PAHLRRETYT DDLPPPPVPP PAIKSPTVQS KAQLEVRPVM VPKLPSLEAR
TERSSDRKGA SYKGRDVLDG RQVADMRPNP GDPREAQEQQ NDGKGRGNKA AKRDLPPAKT
HLIQEDILPY CRPTFPTSNN PRDPSSSSSM SSRGSGGRQR EQANVGRRNI AEMQVLGGYE
RGEDNNEELE VPIIFFQVCQ H
//
