ID A0A287BK92_PIG Unreviewed; 262 AA.
AC A0A287BK92; A0A8D1PKG2;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Gap junction protein {ECO:0000256|RuleBase:RU000630};
GN Name=GJB7 {ECO:0000313|Ensembl:ENSSSCP00000057018.1,
GN ECO:0000313|VGNC:VGNC:88467};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000057018.1, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000057018.1, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000057018.1,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HCZ83802.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000057018.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC pairs of transmembrane channels, the connexons, through which materials
CC of low MW diffuse from one cell to a neighboring cell.
CC {ECO:0000256|RuleBase:RU000630}.
CC -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC {ECO:0000256|RuleBase:RU000630}.
CC -!- SUBCELLULAR LOCATION: Cell junction, gap junction
CC {ECO:0000256|ARBA:ARBA00004610}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU000630}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU000630}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the connexin family.
CC {ECO:0000256|RuleBase:RU000630}.
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DR EMBL; DQIR01028327; HCZ83802.1; -; Transcribed_RNA.
DR RefSeq; XP_003121336.1; XM_003121288.3.
DR RefSeq; XP_005659336.1; XM_005659279.2.
DR STRING; 9823.ENSSSCP00000057018; -.
DR PaxDb; 9823-ENSSSCP00000004642; -.
DR Ensembl; ENSSSCT00000059940.2; ENSSSCP00000057018.1; ENSSSCG00000033562.2.
DR Ensembl; ENSSSCT00005011066.1; ENSSSCP00005006482.1; ENSSSCG00005007362.1.
DR GeneID; 100156827; -.
DR KEGG; ssc:100156827; -.
DR CTD; 375519; -.
DR VGNC; VGNC:88467; GJB7.
DR eggNOG; ENOG502QTN2; Eukaryota.
DR GeneTree; ENSGT01030000234513; -.
DR OMA; NACFDHF; -.
DR OrthoDB; 5301774at2759; -.
DR Reactome; R-SSC-190861; Gap junction assembly.
DR Proteomes; UP000008227; Chromosome 1.
DR Bgee; ENSSSCG00000033562; Expressed in metanephros cortex and 7 other cell types or tissues.
DR GO; GO:0005922; C:connexin complex; IBA:GO_Central.
DR GO; GO:0005243; F:gap junction channel activity; IBA:GO_Central.
DR GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
DR Gene3D; 1.20.1440.80; Gap junction channel protein cysteine-rich domain; 1.
DR InterPro; IPR000500; Connexin.
DR InterPro; IPR019570; Connexin_CCC.
DR InterPro; IPR017990; Connexin_CS.
DR InterPro; IPR013092; Connexin_N.
DR InterPro; IPR038359; Connexin_N_sf.
DR PANTHER; PTHR11984; CONNEXIN; 1.
DR PANTHER; PTHR11984:SF26; GAP JUNCTION BETA-7 PROTEIN; 1.
DR Pfam; PF00029; Connexin; 2.
DR PRINTS; PR00206; CONNEXIN.
DR SMART; SM00037; CNX; 1.
DR SMART; SM01089; Connexin_CCC; 1.
DR PROSITE; PS00408; CONNEXINS_2; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Gap junction {ECO:0000256|ARBA:ARBA00022868,
KW ECO:0000256|RuleBase:RU000630};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000630};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 118..143
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 178..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 42..75
FT /note="Connexin N-terminal"
FT /evidence="ECO:0000259|SMART:SM00037"
FT DOMAIN 134..201
FT /note="Gap junction protein cysteine-rich"
FT /evidence="ECO:0000259|SMART:SM01089"
SQ SEQUENCE 262 AA; 29974 MW; C78C4106B8398C8B CRC64;
MSWMFLRDLL SGVNKYSTGI GRIWLAVVFI FRLLVYMVAA EHVWKDEQKE FECNIRQPGC
ENVCFDYFFP ISQVRLWALQ LIMVSTPSLL VVLHVAYRQG REKRHRKKLY VSPGTMDGGL
WYTYLISLVV KTGFEIGFLV LFYKLYGGFS VPYLMKCDLQ PCPNTVDCFV SKPTEKTIFI
LFLVITSCLC VVLNFTELSF LVLKCFIKCC LQKYSKGLKS SVCDCHNLSY VKCGEVGAPA
LFQKHHVDSA LSTPQRGETQ EG
//
