ID A0A287BL81_PIG Unreviewed; 1742 AA.
AC A0A287BL81;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Collagen type VI alpha 3 chain {ECO:0000313|Ensembl:ENSSSCP00000056925.1};
GN Name=COL6A3 {ECO:0000313|Ensembl:ENSSSCP00000056925.1,
GN ECO:0000313|VGNC:VGNC:95982};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000056925.1, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000056925.1, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000056925.1,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000056925.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Collagen VI acts as a cell-binding protein.
CC {ECO:0000256|ARBA:ARBA00043858}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the type VI collagen family.
CC {ECO:0000256|ARBA:ARBA00044000}.
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DR Ensembl; ENSSSCT00000047656.3; ENSSSCP00000056925.1; ENSSSCG00000027331.4.
DR VGNC; VGNC:95982; COL6A3.
DR GeneTree; ENSGT00940000156462; -.
DR Proteomes; UP000008227; Chromosome 15.
DR Bgee; ENSSSCG00000027331; Expressed in subcutaneous adipose tissue and 32 other cell types or tissues.
DR ExpressionAtlas; A0A287BL81; baseline and differential.
DR CDD; cd01481; vWA_collagen_alpha3-VI-like; 2.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 7.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR041900; vWA_collagen_alpha3-VI-like.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR22588:SF6; COLLAGEN ALPHA-4(VI) CHAIN; 1.
DR PANTHER; PTHR22588; UNCHARACTERIZED; 1.
DR Pfam; PF01391; Collagen; 1.
DR Pfam; PF00092; VWA; 7.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00327; VWA; 7.
DR SUPFAM; SSF53300; vWA-like; 7.
DR PROSITE; PS50234; VWFA; 7.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A287BL81};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT DOMAIN 147..322
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 339..511
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 531..707
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 735..906
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 938..1111
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1141..1314
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1340..1526
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 1543..1742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1610..1626
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1634..1671
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1742 AA; 188950 MW; 795B985421C6C5FD CRC64;
MELENTAGKP WRPRNRISKF VLCAAQSPAQ KCAAQSPPKA AQFSRAPASC KDHGGVFRLH
RGSPLLQKDK ETQRVGKACV RCAHNCSAEP GTLASPGLLR VLTWCLDKIK MRKHRHLPLV
AIFCLFFSGF SFTRAQQQAV IEVNKRDIVF LVDGSSALGP ANFQAIRDFI AKVIQRLDIG
QDLIQVAVAQ YADTVRPEFY FNTHPNKREV MAAVRRMKPL DGAALYTGSA LEFVRNNMFT
SEAGYRAAEG VPRLLVLITG GKSLDDVSQP AQELKRSSIM AFAVGNKAAD QAELEEIAFD
PSLVFIPTEF RASPLQGVLS SLLAPLRTLS GTTEESKRDI LFLFDGSGNL LGQFSAVRDF
LYKVIDELDV KPDGTRIAVA QYSDNVRIES SFAEHQTKPE ILNLVKRMKL KTGKALNLGY
ALDFAQRYIF VKSNGSRIED GVLQILVLLV AGRSSDSVDR PALNLKQSGV VPFILQAKNA
DPGELELIVP SPAFILAAES LPKIGDLQPH IVNLLKSVQN GAPTPVSGEK DVVFLIDGSE
GVRSGFPLLK EFVQRVVESL DVGPDRVRVA VVQYSDRTRP EFYLNSYMDQ QSVVNAVRQL
TLLGGPIPNT GAALDFVLRD ILTESAGSRI AEGIPQLLIV LTADRSGDDV RGPSVVLKRG
GAVPIGIGIG NADITEMQTI SFIPDFAVAI PTFRQLGTVQ QVISERVTRL DREELRRLQA
SVVPLTSPGV SGKRDVVFLI DGSQTAGPEF QYIRTLIERL VDSLDVGFDT SRVAVIQFSE
DPRVEFLLNA HSSKDEVQNA VRRLRPKGGR RINIGGALEY VSKNIFKRPL GSRIEEGVPQ
FLILISSGKS DDEVDDSAAE LKQFGVAPLT IARNADPEEL VKISLSPEYV FSVSTFRELP
SLEQKLLTPI TTLTAEQIQQ LLASTSYPPP AVESDAADIV FLIDSSDGVK PDGIAHIRDF
VIRIVRRLNI GPNKVRVGVV QFSNDVFPEF YLKTYRSQAS VLDAIRRLRF KGGSPLNTGK
ALEFVARNFF VKSAGSRIED GVPQHLVLFL GGKSQDDVSR YSQVMGSSGI VRLGVGDRNI
DRTELQTITN DPRLVFTVRE FRELPNIEER VMNSFGPSGV TPAPPGVDIL PPSRPEKKKA
DIVFLLDGSI NFRRDSFQEV LRFVSEIVDT VYEGGDSIQV GLVQYNSDPT DEFFLKDFST
KQQIIDAINK VVYKGGRHAN TKVGLEHLRL NQFVPEAGSR LEQRVPQIAF VITGGKSVED
AQEASLALTQ RGVKVFAVGV RNIDSEEVGK IASNSATAFR VGNVQELSEL SEQVLETLHD
AMHETLCPGV TDISKACNLE VILGFDGSRD QNIFVAQKGF ESKVDTILNR ISQMQRISCS
GTQMPTVRVS VVATTPAGPV EAFDFAEYQP EMFEKILGMR TQHPYVLTAD TLKLYQNKFR
QGSPGSVKVV IHFTDGADGD LADLQRASEA LRQEGVQALI LVGLERVPNL EQLMQLEFGR
GFTYNRPLRL NLLDLDYELA EQLDNIAEKA CCGVPCKCSG QRGDRGPIGS IGPKGIPGED
GYRGYPGDEG GPGERGPPGM NGTQGFQGCP GQRGIKGSRG FPGEKGELGE IGLDGLDGED
GDKGLPGTSG DKGSPGRRGD KGPKGDKGER GDVGIRGDPG DTGRDSQQRG PKGESGDLGP
MGLPGRDGVS GSPGEPGKSG GFGRRGPAGL KGNKGGPGQQ GSVGEQGTRG AQGHLVPLVL
QA
//
