ID A0A287BMS3_PIG Unreviewed; 225 AA.
AC A0A287BMS3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 3.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Tetraspanin 2 {ECO:0000313|Ensembl:ENSSSCP00000057373.3};
GN Name=TSPAN2 {ECO:0000313|Ensembl:ENSSSCP00000057373.3,
GN ECO:0000313|VGNC:VGNC:94509};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000057373.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000057373.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000057373.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000057373.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC {ECO:0000256|ARBA:ARBA00006840}.
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DR AlphaFoldDB; A0A287BMS3; -.
DR STRING; 9823.ENSSSCP00000057373; -.
DR Ensembl; ENSSSCT00000056235.3; ENSSSCP00000057373.3; ENSSSCG00000006748.5.
DR VGNC; VGNC:94509; TSPAN2.
DR GeneTree; ENSGT00940000157504; -.
DR InParanoid; A0A287BMS3; -.
DR Proteomes; UP000008227; Chromosome 4.
DR Bgee; ENSSSCG00000006748; Expressed in stomach and 37 other cell types or tissues.
DR ExpressionAtlas; A0A287BMS3; baseline and differential.
DR GO; GO:0043209; C:myelin sheath; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0014002; P:astrocyte development; IEA:Ensembl.
DR GO; GO:0061564; P:axon development; IEA:Ensembl.
DR GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR GO; GO:0014005; P:microglia development; IEA:Ensembl.
DR GO; GO:0042552; P:myelination; IEA:Ensembl.
DR GO; GO:0048709; P:oligodendrocyte differentiation; IEA:Ensembl.
DR CDD; cd03151; CD81_like_LEL; 1.
DR Gene3D; 1.10.1450.10; Tetraspanin; 1.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR018503; Tetraspanin_CS.
DR InterPro; IPR008952; Tetraspanin_EC2_sf.
DR PANTHER; PTHR19282; TETRASPANIN; 1.
DR PANTHER; PTHR19282:SF155; TETRASPANIN-2; 1.
DR Pfam; PF00335; Tetraspanin; 1.
DR PRINTS; PR00259; TMFOUR.
DR SUPFAM; SSF48652; Tetraspanin; 1.
DR PROSITE; PS00421; TM4_1; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 54..75
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 87..111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 225 AA; 24685 MW; D3B9218D01E81619 CRC64;
MGRFRGGLRC IKYLLLGFNL LFWLAGSAVI AFGLWFRFGG TMKDFSSEDK SPEYFYMGLY
VLVGAGVLMM AVGFFGCCGA TRESQCVLGS FFTCLLVIFA AEVTTGVFAF IGKGVAIRHV
QTMYEEAYND YLRDREKGNG TLITFHSAFQ CCGKESSEQV QPTCPKELLG HKNCIDEIET
IISVKLQLVG IVGIGIAGLT VRKSQNVPSL PSVKPESLHP ISLQM
//
