ID A0A287BMU9_PIG Unreviewed; 237 AA.
AC A0A287BMU9; A0A4X1U6G2;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=TIR domain-containing adapter molecule 2 {ECO:0000313|EMBL:HCZ88106.1};
DE SubName: Full=Toll like receptor adaptor molecule 2 {ECO:0000313|Ensembl:ENSSSCP00000031565.1};
GN Name=TICAM2 {ECO:0000313|Ensembl:ENSSSCP00000031565.1};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000031565.1, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000031565.1, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000031565.1,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HCZ88106.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000031565.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; DQIR01032631; HCZ88106.1; -; Transcribed_RNA.
DR EMBL; DQIR01115672; HDA71148.1; -; Transcribed_RNA.
DR RefSeq; NP_001191280.1; NM_001204351.1.
DR STRING; 9823.ENSSSCP00000035772; -.
DR PaxDb; 9823-ENSSSCP00000015122; -.
DR Ensembl; ENSSSCT00000052859.3; ENSSSCP00000031565.1; ENSSSCG00000038141.3.
DR Ensembl; ENSSSCT00000057729.3; ENSSSCP00000035772.1; ENSSSCG00000038141.3.
DR Ensembl; ENSSSCT00005056645.1; ENSSSCP00005034870.1; ENSSSCG00005035521.1.
DR GeneID; 100520421; -.
DR KEGG; ssc:100520421; -.
DR CTD; 353376; -.
DR eggNOG; ENOG502S2I6; Eukaryota.
DR GeneTree; ENSGT00940000164712; -.
DR OMA; SAWTIIL; -.
DR OrthoDB; 5315700at2759; -.
DR Reactome; R-SSC-140534; Caspase activation via Death Receptors in the presence of ligand.
DR Reactome; R-SSC-166016; Toll Like Receptor 4 (TLR4) Cascade.
DR Reactome; R-SSC-166166; MyD88-independent TLR4 cascade.
DR Reactome; R-SSC-2562578; TRIF-mediated programmed cell death.
DR Reactome; R-SSC-6798695; Neutrophil degranulation.
DR Reactome; R-SSC-936964; Activation of IRF3, IRF7 mediated by TBK1, IKBKE.
DR Reactome; R-SSC-937041; IKK complex recruitment mediated by RIP1.
DR Reactome; R-SSC-937072; TRAF6-mediated induction of TAK1 complex within TLR4 complex.
DR Reactome; R-SSC-975163; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
DR Proteomes; UP000008227; Chromosome 2.
DR Bgee; ENSSSCG00000038141; Expressed in blood and 34 other cell types or tissues.
DR GO; GO:0005768; C:endosome; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005543; F:phospholipid binding; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
DR GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0006909; P:phagocytosis; IEA:Ensembl.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IBA:GO_Central.
DR GO; GO:0071651; P:positive regulation of chemokine (C-C motif) ligand 5 production; IEA:Ensembl.
DR GO; GO:1900017; P:positive regulation of cytokine production involved in inflammatory response; IBA:GO_Central.
DR GO; GO:2000494; P:positive regulation of interleukin-18-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR GO; GO:0002735; P:positive regulation of myeloid dendritic cell cytokine production; IBA:GO_Central.
DR GO; GO:0032816; P:positive regulation of natural killer cell activation; IBA:GO_Central.
DR GO; GO:0032729; P:positive regulation of type II interferon production; IEA:Ensembl.
DR GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central.
DR GO; GO:0070671; P:response to interleukin-12; IEA:Ensembl.
DR GO; GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; IBA:GO_Central.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR046946; TCAM1/2.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR47230; TIR DOMAIN-CONTAINING ADAPTER MOLECULE 1; 1.
DR PANTHER; PTHR47230:SF2; TIR DOMAIN-CONTAINING ADAPTER MOLECULE 2; 1.
DR Pfam; PF13676; TIR_2; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT DOMAIN 75..231
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 46..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 237 AA; 26879 MW; FDBDB25152B32208 CRC64;
MGIGKSKTDP CLLSLSWSKS HGVDTSQKPH ETDCTISEEI PLHGGEDVAC SSSAEMPTGE
QEGADGVEEM PEEEAEEEVF LKFVILHAED DTDEALRVQN LLQNDFGIKP GIIFAEMPCG
RQHLQNLDDA VNGSAWTILL LTENFLRDTW CKFQFYTSLM NSVNRQHKYN SVIPMRPLNN
PLPREKTPFA LRTINALEEE SRGFPTQVER IFQESVYQIQ QAIWKETRNL VQRQLIA
//
