ID A0A287BNK7_PIG Unreviewed; 4543 AA.
AC A0A287BNK7;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 3.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Plectin {ECO:0000313|Ensembl:ENSSSCP00000058201.3};
GN Name=PLEC {ECO:0000313|Ensembl:ENSSSCP00000058201.3,
GN ECO:0000313|VGNC:VGNC:91530};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000058201.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000058201.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000058201.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000058201.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSSSCT00000055970.3; ENSSSCP00000058201.3; ENSSSCG00000039094.3.
DR VGNC; VGNC:91530; PLEC.
DR GeneTree; ENSGT00940000159045; -.
DR Proteomes; UP000008227; Chromosome 4.
DR Bgee; ENSSSCG00000039094; Expressed in psoas major muscle and 43 other cell types or tissues.
DR ExpressionAtlas; A0A287BNK7; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR CDD; cd21188; CH_PLEC-like_rpt1; 1.
DR CDD; cd21238; CH_PLEC_rpt2; 1.
DR CDD; cd00176; SPEC; 2.
DR Gene3D; 1.20.58.1060; -; 1.
DR Gene3D; 1.20.58.60; -; 5.
DR Gene3D; 3.30.160.780; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 3.90.1290.10; Plakin repeat; 6.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR041615; Desmoplakin_SH3.
DR InterPro; IPR041573; Desmoplakin_Spectrin-like.
DR InterPro; IPR049538; PCN-like_spectrin-like_rpt.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR035915; Plakin_repeat_sf.
DR InterPro; IPR001101; Plectin_repeat.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR PANTHER; PTHR23169:SF23; SHORT STOP, ISOFORM H; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00681; Plectin; 19.
DR Pfam; PF17902; SH3_10; 1.
DR Pfam; PF18373; Spectrin_2; 1.
DR Pfam; PF21019; Spectrin_3; 1.
DR Pfam; PF21020; Spectrin_4; 1.
DR Pfam; PF21097; SR_plectin_7; 1.
DR SMART; SM00033; CH; 2.
DR SMART; SM00250; PLEC; 33.
DR SMART; SM00150; SPEC; 4.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF75399; Plakin repeat; 7.
DR SUPFAM; SSF46966; Spectrin repeat; 4.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
PE 1: Evidence at protein level;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A287BNK7};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 42..157
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 170..275
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1479..1503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1653..1686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1953..1999
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2020..2171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2524..2573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2614..2646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4239..4275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4470..4543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 654..681
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 727..776
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1118..1162
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1234..1288
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1656..1686
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2056..2071
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2073..2116
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2545..2573
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2632..2646
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4239..4268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4470..4524
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4543 AA; 515974 MW; 04D4C74B6E0E86D6 CRC64;
MSQHRLRVPE PEGLGQKRTS SEDNLYLAVL RASEGKKDER DRVQKKTFTK WVNKHLIKAQ
RHISDLYEDL RDGHNLISLL EVLSGDSLPR ERDVIRSSRL PREKGRMRFH KLQNVQIALD
YLRHRQVKLV NIRNDDIADG NPKLTLGLIW TIILHFQISD IQVSGQSEDM TAKEKLLLWS
QRMVEGYQGL RCDNFTSSWR DGRLFNAIIH RHKPMLIDMN KVYRQSNLEN LDQAFSVAER
DLGVTRLLDP EDVDVPQPDE KSIITYVSSL YDAMPRVPDA QDGVKANELQ LRWQEYRELV
LLLLQWVRQH TAAFEERRFP SSFEEVEVLW CQFLKFKETE LPAKEADKNR SKSIYQTLEG
AVQAGQLKMP PGYHPLDVEK EWGKLHVAIL EREKQLRSEF ERLECLQRIV SKLQMEAGLC
EEQLNQADAL LQSDVRLLAA GKAPQRASEV ERDLDKADGM IRLLFNDVQT LKDGRHPQGE
QMYRRVYRLH ERLVAIRTEY NLRLRGAARH PELEDSSLRY LQELLAWVEE NQRRVDGAEW
GVDLPSVEAQ LGSHRGLHQS IEEFRAKIER ARADEGQLSP ATRGAYRDCL GRLDLQYAKL
LNSSKARLRS LESLHGFVAA ATKELMWLSE KEEEEVAFDW SERNANMVAK KEAYSALMRE
LELKEKKIKE IQSTGDRLLR EDHPARPTVE SFQAALQTQW SWMLQLCCCI EAHLKENTAY
FQFFSDVREA EEQLRKLQET LRRKYTCDRS ITVTRLEDLL QDAQDEKDQL NEYRGHLSGL
AKRAKAIVQL KPRNPAHPTR GHVPLLAVCD YKQVEVTVHK GDECQMVGPA QPFHWKVLSS
SGSEAAVPSV CFLVPPPNQE AQDAITRLEA QHQALVALWH QLHTDMKSLL AWQSLSRDVQ
LIRSWSLVTF RTLKPEEQRQ ALRSLELHYQ AFLRDSQDAG GFGPEDRLQA EREYGSCSRH
YQQLLQSLEQ GEQEESRCQR CISELKDIRL QLEACETRTV HRLRLPLDKE PARECAQRIA
EQQKAQAEVE GLGKGVARLS VEAEKVLALP EPSPAAPTLR SELELTLGKL EQVRSLSAIY
LEKLKTISLV IRSTQGAEEV LRAHEEHLKE AQTVPATLPE LEATKAALKK LRAQAEAQQP
VFDALRDELR GAQEVGERLQ QRHGERDVEV ERWRERVTQL LERWQAVLVQ TDVRQRELEQ
LGRQLRYYRE SADPLGAWLQ DAKRRQEQIQ AVPLAHSQAV REQLRQEKAL LEEIERHGEK
VEECQKFAKQ YINAIKDYEL QLVTYKAQLE PVASPAKKPK VQSGSESVIQ EYVDLRTRYS
ELTTLTSQYI KFITETLRRM EEEERLAEQQ RAEERERLAE VEAALEKQRQ LAEAHAQAKA
QAEREAQELQ RRMQEEVARR EEVAVDAQQQ KRSIQEELQH LRQSSEAEIQ AKARQVEAAE
RSRLRIEEEI RVVRLQLEAT ERQRGGAEGE LQALRARAEE AEAQKRQAQE EAERLRRQVQ
DETQRKRQAE AELALRVKAE AEAAREKQRA LQALEELRLQ AEEAERRLRQ AEAERARQVQ
VALETAQRSA EAELQSKQAS FVEKTAQLER TLKEEHVTVA QLREEATRRA QQQAEAERAR
EEAERELERW QLKANEALRL RLQAEEVAQQ KSLAQAEAEK QKEEAEREAR RRGKAEEQAV
RQRELAEQEL EKQRQLAEGT AQQRLAAEQE LIRLRAETEQ GEQQRQLLEE ELARLQQEAA
VATQKRQELE AELAKVRAEM EVLLASKARA EEESRSTSEK SKQRLEAEAG RFRELAEEAA
RLRALAEEAK RQRQLAEEDA ARQRAEAERV LAEKLAAISE ATRLKTEAEI ALKEKEAENE
RLRRLAEDEA FQRRRLEEQA AQHKADIEER LAQLRKASES ELERQKGLVE DTLRQRRQVE
EEILALKANF EKAAAGKAEL ELELGRIRGN AEDTLRSKEQ AEQEAARQRQ LAAEEERRRR
EAEERVQKSL AAEEEAARQR KAALEEVERL KAKVEEARRL RERAEQESAR QLQLAQEAAQ
KRLQAEEKAH AFAVQQKEQE LQQTLQQEQS VLERLRGEAE AARRAAEEAE EARERAEREA
AQSRRQLEEA ERLKQSAEEQ AQAQAQAQAA AEKLRKEAEQ EAARRAQAEQ AALRQKQAAD
AEMEKHKKFA EQTLRQKAQV EQELTALRLQ LEETDHQKSI LDEELQRLKA EVTEAARQRS
QVEEELFSVR VQMEELGKLK ARIEAENRAL VLRDKDNTQR LLQEEAEKMK QVAEEAARLT
VAAQEAARLR QLAEEDLAQQ RSLAEKMLKE KMQAVQEATR LKAEAELLQQ QKDLAQEQAR
RLQEDKEQMA QQLAQETQGF QRTLETERQR QLEMSAEAER LRLRVAEMSR AQARAEEDAQ
RFRKQAEEIG ERLHRTELAT QEKVTLVQTL ETQRQQSDQD AERLREAIAE LEREKAKLKQ
EAELLQLKSE EMQTVQQEQL LQETQALQQS FLSEKDSLLQ RERFIEQEKA KLEQLFQDEV
AKAQKLREEQ QRQQQQMEQE KQQLVASMEE ARRRQHAAEE GVRRKQEELQ RLEQQRQQQE
KLLAEENQRL RERLQHLEEE HRAALAHSEE IAASQAAAAK ALPNGRDAPD GPAVEAEPEH
AFDGLRRKVP AQRLQEVGIL STEELQRLAQ GRTTVAELAQ REDVRHYLQG RSGIAGLLLK
PANEKLTIYA ALRRQLLSPG TALILLEAQA ASGFLLDPVR NRWLTVNEAV KEGLVGPELH
HKLLSAERAV TGYKDPYTGE QISLFQAMKK DLIVREHGLR LLEAQIATGG IIDPVRSHRV
PVAVAYQRGY FDEEMSRVLE DPSDDTKGFF DPNTHENLTY MQLLERCVED PETGLRLLPL
TDQAAKAGEL VYTDSEARDV FEKATVSAPF GKFQGRTVTI WELINSEYFT AEQRQELLRQ
FRTGKVTVEK IIKIVVTVLE EHEQKSQLCF KGLRALVPAA ELLESRVIDH DLYRQLQRGE
RSVQEVAEVE AVRRALRGSS VIAGVWLEEA GRKLSVYEAL KKDLLQPEAA VALLEAQAGT
GHIIDPATSA RLTVDEAVRA GLVGPELHEK LLSAEKAVTG YKDPYSGQSV SLFQALKKGL
IPREQGLRLL DAQLCTGGIV DPSKSHRVPL DVACARGYLD EETSTALSAP RDDAKAYRDP
STWEPVSYRQ LQQQCRADQL TGLSLLPLSE EAARARQQEL YSELQAREAF QKATVEVPVG
SFQGRTVTVW ELISSEYFSA EQRRELLRQF RTGKVTVEKI IKIVITIVEE AEAVRQERLS
FSGLRAPVPA SELVAAGVLS QAQFEQLQDG RTSVKDLSEV DSVRTLLQGS GCLAGVYLED
SREKVSVYEA MRRGLLRPST AALLLEAQAA TGFLVDPVRN QRLYVHEAVK AGVVGPELHE
KLLSAEKAVT GYKDPYSGST ISLFQAMKKG LVLREHGLRL LEAQVATGGV IDPVHSHRVP
LAVACQRGYL DEELSRVLED PGDDAKGFFD PNTHENLTYG QLLARCVEDP ETGLRLLPLR
GAEKAEVVET TRVYTEEETR RAFEETQIDI PGGGRHGGAT MSLWEVMQSD LIPEEQRARL
LADFQAGRVT KERMIVIIIE IIERTEVVRQ QHAASYEHGR RRLTAEDLVE ARVISREAYS
LLREGARTLR EVLEAESAWR YLHGTGCVAG VYLPGSKQTL SVYQALKKGL LSAEVARLLL
EAQAATGFLL DPAKGERLTV DEAVRKGLVG PELHDRLLSA ERAVSGYRDP YTEQTISLFE
AMRKDLIPAE EALRLLDAQL ATGGIMDPRL SIHLPLEVAY QRGYLNKDTH DQLSEPSEVR
GYLDPSTDER LSYTQLLRRC RRDEGSGLLL LPLSDARQLT FRGLRKQITV EELVRSHVMD
EATALRLQEG LTSVEEVSKN LQKFLEGTSS IAGVLVDATK ERLSVYQAMK KGIIRPGTAF
ELLEAQAATG YVIDPIKGLK LTVEEAVRMG IVGPEFKDKL LSAERAVTGY RDPYSGKLIS
LFQAMKKGLI LKDHGIRLLE AQIATGGIID PEESHRLPVD VAYQRGLFDE EMNEILTDPS
DDTKGFFDPN TEENLTYLQL MERCVTDPQT GLRLLPLKEK KRERKTSSKS SVRKRRVVIV
DPETGKEMSV YEAYRKGLID HQTYLELSEQ ECEWEEITTS SSDGVVKSMI IDRRSGRQYD
IDEALAKSLI DRSALDQYRA GTLSITEFAD MLSGSAGGFR SRSSSVGSSS SYPVSPAVSR
TPLASWSDPT EETGPVAGIL DTETLEKVSI TEAMHRNLVD NITGQRLLEA QACTGGIIDP
GTGERFPVTE AVNKGLVDKI MVDRINLAQK AFCGFEDPRT KTRMSAAQAL KKGWLYYEAG
QRFLEAQYLT GGLIEPDTPG RVPLDEALQR GTVDARTAQK LRDVSAYSKY LTCPKTKLKI
SYKDALDRSM VEEGTGLRLL EAAAQSSKGY YSPYSVSGSG STAGSRSGSR TGSRAGSRRG
SFDATGSGFS MTFSSSSYSS SGYGRRYASG PAPSLGGPES AVA
//
