ID   A0A287BRC0_PIG          Unreviewed;      1227 AA.
AC   A0A287BRC0;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2019, sequence version 2.
DT   27-MAR-2024, entry version 34.
DE   RecName: Full=Cytoplasmic FMR1-interacting protein {ECO:0000256|PIRNR:PIRNR008153};
GN   Name=CYFIP2 {ECO:0000313|Ensembl:ENSSSCP00000059181.2,
GN   ECO:0000313|VGNC:VGNC:87127};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000059181.2, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000059181.2, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000059181.2,
RC   ECO:0000313|Proteomes:UP000008227};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00000059181.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the CYFIP family.
CC       {ECO:0000256|ARBA:ARBA00025790, ECO:0000256|PIRNR:PIRNR008153}.
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DR   AlphaFoldDB; A0A287BRC0; -.
DR   SMR; A0A287BRC0; -.
DR   Ensembl; ENSSSCT00000054700.2; ENSSSCP00000059181.2; ENSSSCG00000017054.5.
DR   VGNC; VGNC:87127; CYFIP2.
DR   eggNOG; KOG3534; Eukaryota.
DR   GeneTree; ENSGT00500000044831; -.
DR   Proteomes; UP000008227; Chromosome 16.
DR   Bgee; ENSSSCG00000017054; Expressed in prefrontal cortex and 41 other cell types or tissues.
DR   ExpressionAtlas; A0A287BRC0; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0030833; P:regulation of actin filament polymerization; IEA:InterPro.
DR   InterPro; IPR009828; CYRIA/CYRIB_Rac1-bd.
DR   InterPro; IPR008081; Cytoplasmic_FMR1-int.
DR   PANTHER; PTHR12195:SF3; CYTOPLASMIC FMR1-INTERACTING PROTEIN 2; 1.
DR   PANTHER; PTHR12195; CYTOPLASMIC FMR1-INTERACTING PROTEIN-RELATED; 1.
DR   Pfam; PF07159; CYRIA-B_Rac1-bd; 1.
DR   Pfam; PF05994; FragX_IP; 1.
DR   PIRSF; PIRSF008153; FMR1_interacting; 2.
DR   PRINTS; PR01698; CYTOFMRPINTP.
PE   1: Evidence at protein level;
KW   Cytoplasm {ECO:0000256|PIRNR:PIRNR008153};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:A0A287BRC0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT   DOMAIN          77..247
FT                   /note="CYRIA/CYRIB Rac1 binding"
FT                   /evidence="ECO:0000259|Pfam:PF07159"
SQ   SEQUENCE   1227 AA;  142577 MW;  497CC1C4B258515C CRC64;
     MTTHVTLEDA LSNVDLLEEL PLPDQQPCIE PPPSSIMYQA NFDTNFEDRN AFVTGIARYI
     EQATVHSSMV KCNEQPNRVE IYEKTVEVLE PEVTKLMKFM YFQRKAIERF CSEVKRLCHA
     ERRKDFVSEA YLLTLGKFIN MFAVLDELKN MKCSVKNDHS AYKRAAQFLR KMADPQSIQE
     SQNLSMFLAN HNRITQCLHQ QLEVIPGYEE LLADIVNICV DYYENKMYLT PSEKHMLLKV
     MGFGLYLMDG NVSNIYKLDA KKRINLSKID KFFKQLQVVP LFGDMQIELA RYIKTSAHYE
     ENKSKWTCTQ SSISPQYNIC EQMVQIRDDH IRFISELARY SNSEVVTGSG LDSQKSDEEY
     RELFDLALRG LQLLSKWSAH VMEVYSWKLV HPTDKFCNKD CPGTAEEYER ATRYNYTSEE
     KFAFVEVIAM IKGLQVLMGR MESVFNQAIR NTIYAALQDF AQVTLREPLR QAVRKKKNVL
     ISVLQAIRKT ICDWEGGREP PNDPCLRGEK DPKGGFDIKV PRRAVGPSST QLYMVRTMLE
     SLIADKSGSK KTLRSSLDGP IVLAIEDFHK QSFFFTHLLN ISEALQQCCD LSQLWFREFF
     LELTMGRRIQ FPIEMSMPWI LTDHILETKE PSMMEYVLYP LDLYNDSAYY ALTKFKKQFL
     YDEIEAEVNL CFDQFVYKLA DQIFAYYKAM AGSVLLDKRF RAECKNYGVI IPYPPSNRYE
     TLLKQRHVQL LGRSIDLNRL ITQRISAAMY KSLDQAISRF ESEDLTSIVE LEWLLEINRL
     THRLLCKHMT LDSFDAMFRE ANHNVSAPYG RITLHVFWEL NFDFLPNYCY NGSTNRFVRT
     AIPFTQEPQR DKPANVQPYY LYGSKPLNIA YSHIYSSYRN FVGPPHFKTI CRLLGYQGIA
     VVMEELLKIV KSLLQGTILQ YVKTLIEVMP KICRLPRHEY GSPGILEFFH HQLKDIIEYA
     ELKTDVFQSL REVGNAILFC LLIEQALSQE EVCDLLHAAP FQNILPRVYI KEGERLEVRM
     KRLEAKYAPL HLVPLIERLG TPQQIAIARE GDLLTKERLC CGLSMFEVIL TRIRSYLQDP
     IWRGPPPTNG VMHVDECVEF HRLWSAMQFV YCIPVGTNEF TAEQCFGDGL NWAGCSIIVL
     LGQQRRFDLF DFCYHLLKVQ RQDGKDEIIK NVPLKKMADR IRKYQILNNE VFAILNKYMK
     SVETDSSTVE HVRCFQPPIH QSLATTC
//