ID A0A287BRN3_PIG Unreviewed; 1988 AA.
AC A0A287BRN3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Unc-13 homolog B {ECO:0000313|Ensembl:ENSSSCP00000059304.2};
GN Name=UNC13B {ECO:0000313|Ensembl:ENSSSCP00000059304.2,
GN ECO:0000313|VGNC:VGNC:103199};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000059304.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000059304.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000059304.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000059304.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSSSCT00000055365.3; ENSSSCP00000059304.2; ENSSSCG00000005305.5.
DR VGNC; VGNC:103199; UNC13B.
DR GeneTree; ENSGT00940000154929; -.
DR Proteomes; UP000008227; Chromosome 1.
DR Bgee; ENSSSCG00000005305; Expressed in oocyte and 43 other cell types or tissues.
DR ExpressionAtlas; A0A287BRN3; baseline and differential.
DR GO; GO:0098793; C:presynapse; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0019992; F:diacylglycerol binding; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR CDD; cd20859; C1_Munc13-2-like; 1.
DR CDD; cd04027; C2B_Munc13; 1.
DR CDD; cd08395; C2C_Munc13; 1.
DR Gene3D; 1.10.357.50; -; 1.
DR Gene3D; 1.20.58.1100; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR010439; MUN_dom.
DR InterPro; IPR014770; Munc13_1.
DR InterPro; IPR014772; Munc13_dom-2.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR027080; Unc-13.
DR InterPro; IPR037302; Unc-13_C2B.
DR PANTHER; PTHR10480; PROTEIN UNC-13 HOMOLOG; 1.
DR PANTHER; PTHR10480:SF8; PROTEIN UNC-13 HOMOLOG B; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF06292; MUN; 1.
DR PRINTS; PR00360; C2DOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM01145; DUF1041; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS51258; MHD1; 1.
DR PROSITE; PS51259; MHD2; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 856..906
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 962..1086
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1392..1535
FT /note="MHD1"
FT /evidence="ECO:0000259|PROSITE:PS51258"
FT DOMAIN 1642..1784
FT /note="MHD2"
FT /evidence="ECO:0000259|PROSITE:PS51259"
FT DOMAIN 1817..1943
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 359..406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 603..643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..375
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..406
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1988 AA; 222123 MW; 9B0AAD47B47EBCB7 CRC64;
MKRLLQESEE EIMVTLGPSS RLSPDKAKAE TLCGIKSKSS GPAGSLPEDN FLPSSCGSVA
SAIDGGRDGG LAQCCSFGQQ ASSQLPLGST ACVSGSGSQD LPFASNTTSC QEPSDRDQAK
PLMYRGPGQG CSREQREPLG DVVDYIIREL QGISRLQTEI AELQQHLSQV RGSVDEVSSC
VDSVLSEIEG LQVGSSSLAK VCVGGKAQEP HVDRPSEEAI LYLYGLPEQD GENTMELVHS
FLAKHLCVNG IQCSRHIKEA YRAGKTPAPR PTVVKLANLE HRDLILQKSI LLQSLGVRIA
TREEPSQPQC YKNPQKESLS FLEQKLQDHN SNSLNLDEPV FQVETGDRGP LTEAYQMRAQ
NQHRDPQTPE QQGLCFLPKN NLAKPNDKSK PGDEVQGTSG TSQVISGTYG ELTGREASLS
KLHQFEEPSL VLLSKEENSG KSQVFNQCNQ GLEACKVARI ENNCSDRSEA SSCLSLSGLL
KTEDKLLACE AGLDILSTKQ LEDLLTDKSR RFATLSCDSM MEEIIIGPET FSDMVHIDLN
EEEECAAQVL KDVFEKSSCL GGSQEDEDVE IKFYRSKLGR AIHHFRSALQ GVFQKLENSG
SITPEDLESI ESGSQSENSE RLLGTVSSGG AQDLSVESPG SQESESLLSV VSGGVGISVQ
GDQTSQDPSN ISLASHNLPL AYSLPGFALA PCLGSETCSR PESPKQGRLS LEQVCAETIY
LNKCIDNFKN VLKEKRLRQK KLLHELVQKT DHLSVEDMHP EEKRGALQIP DDGDPSLPQW
LPEGPAGGLY GIDSMPDLRR KKPLPLVSDL SLVQSRKAGI TSAMATRTSL KDEELKSHVY
KKTLQALIYP ISCTTPHNFE VWTATTPTYC YECEGLLWGI ARQGMRCSEC GVKCHEKCQD
LLNADCLQRA AEKSSKHGAE DRTQNIIMAM KDRMKIRERN KPEIFEVIRD VFSVSKVAHV
QQMKTVKQSV LDGTSKWSAK ITITVVCAQG LQAKDKTGSS DPYVTVQVGK TKKRTKTIFG
NLNPVWEEKF HFECHNSSDR IKVRVWDEDD DIKSRVKQRL KRESDDFLGQ TIIEVRTLSG
EMDVWYNLEK RTDKSAVSGA IRLQINVEIK GEEKVAPYHV QYTCLHENLF HYLTDIQGSG
GVQIPEARGD DAWKVYFDET AQEIVDEFAM RYGIESIYQA MTHFACLSSK YMCPGVPAVM
STLLANINAY YAHTTASTNV SASDRFAASN FGKERFVKLL DQLHNSLRID LSTYRNNFPA
GSPERLQDLK STVDLLTSIT FFRMKVQELQ SPPRASQVVK DCVKACLNST YEYIFNNCHD
LYSRQYQLNQ ELPLEEQGPS IRNLDFWPKL ITLIVSIIEE DKNSYTLVLN QFPQELNVGK
VSAEVMWQLF AQDMKYALEE HEKDRLCKSA DYMNLHFKVK WLHNEYVRDL PALQGQVPEY
PAWFEQFVLQ WLDENEDVSL EFLRGALERD KKDGFQQTSE HALFSCSVVD VFTQLNQSFE
IIRKLECPDP NILAHYMRRF AKTIGKVLME YADILSKNFP AYCTKEKMPC ILMNNMQQLR
VQLEKMFEAM GGKELDSEAA DSLKELQVKL NTVLDELSMV FGNSFQVRID ECVRQMADIL
GQVRGPGNAS PNTRASVTQD ADSVLRPLMD FLDGNLTLFA AVCEKTVLKR VLKELWRVVM
NTMERMIVLP PLTDQTGTQL IFTAAKELSH LSKLKDHMVR EETRNLTPKQ CAILDLALDT
IKQYFHAGGN GLKKTFLEKS PDLQSLRYAL SLYTQTTDTL IKTFVRSQTA QVHDGKGIRF
TANEDIQPEK GSGVDDPVGE VSIQVDLFTH PGTGEHKVTV KVVAANDLKW QTAGMFRPFV
EVTMVGPHQS DKKRKFTTKS KSNNWAPKYN ETFFLLGNEE GPEAYELQIC VKDYCFARED
RVLGLAVMPL RDVAAKGSCA CWCPLGRKIH MDETGMTILR ILSQRSNDEV AREFVKLKSE
SRSMEEGS
//
