ID A0A287BTI9_PIG Unreviewed; 464 AA.
AC A0A287BTI9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Tubby-like protein {ECO:0000256|RuleBase:RU361125};
GN Name=TULP3 {ECO:0000313|Ensembl:ENSSSCP00000059563.1,
GN ECO:0000313|VGNC:VGNC:94591};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000059563.1, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000059563.1, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000059563.1,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HDA39181.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000059563.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TUB family. {ECO:0000256|ARBA:ARBA00007129,
CC ECO:0000256|RuleBase:RU361125}.
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DR EMBL; DQIR01083705; HDA39181.1; -; Transcribed_RNA.
DR EMBL; DQIR01097010; HDA52486.1; -; Transcribed_RNA.
DR EMBL; DQIR01285795; HDC41273.1; -; Transcribed_RNA.
DR RefSeq; XP_005664133.1; XM_005664076.2.
DR Ensembl; ENSSSCT00000040316.3; ENSSSCP00000059563.1; ENSSSCG00000000737.5.
DR GeneID; 100511196; -.
DR CTD; 7289; -.
DR VGNC; VGNC:94591; TULP3.
DR GeneTree; ENSGT00940000158155; -.
DR OMA; FPTYFMH; -.
DR OrthoDB; 603296at2759; -.
DR Proteomes; UP000008227; Chromosome 5.
DR Bgee; ENSSSCG00000000737; Expressed in hindlimb bud and 43 other cell types or tissues.
DR GO; GO:0097731; C:9+0 non-motile cilium; IEA:Ensembl.
DR GO; GO:0005930; C:axoneme; IEA:Ensembl.
DR GO; GO:0097546; C:ciliary base; IEA:Ensembl.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IEA:Ensembl.
DR GO; GO:0120160; F:intraciliary transport particle A binding; IEA:Ensembl.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:Ensembl.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
DR GO; GO:0060348; P:bone development; IEA:Ensembl.
DR GO; GO:0007420; P:brain development; IEA:Ensembl.
DR GO; GO:0060434; P:bronchus morphogenesis; IEA:Ensembl.
DR GO; GO:0021953; P:central nervous system neuron differentiation; IEA:Ensembl.
DR GO; GO:0031076; P:embryonic camera-type eye development; IEA:Ensembl.
DR GO; GO:0042733; P:embryonic digit morphogenesis; IEA:Ensembl.
DR GO; GO:0048702; P:embryonic neurocranium morphogenesis; IEA:Ensembl.
DR GO; GO:0061548; P:ganglion development; IEA:Ensembl.
DR GO; GO:0045879; P:negative regulation of smoothened signaling pathway; IEA:Ensembl.
DR GO; GO:0001843; P:neural tube closure; IEA:Ensembl.
DR GO; GO:0061512; P:protein localization to cilium; IEA:Ensembl.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0060831; P:smoothened signaling pathway involved in dorsal/ventral neural tube patterning; IEA:Ensembl.
DR InterPro; IPR025659; Tubby-like_C.
DR InterPro; IPR000007; Tubby_C.
DR InterPro; IPR018066; Tubby_C_CS.
DR InterPro; IPR005398; Tubby_N.
DR PANTHER; PTHR16517; TUBBY-RELATED; 1.
DR PANTHER; PTHR16517:SF138; TUBBY-RELATED PROTEIN 3; 1.
DR Pfam; PF01167; Tub; 1.
DR Pfam; PF16322; Tub_N; 2.
DR PRINTS; PR01573; SUPERTUBBY.
DR PRINTS; PR01574; TUBBYPROTEIN.
DR SUPFAM; SSF54518; Tubby C-terminal domain-like; 1.
DR PROSITE; PS01200; TUB_1; 1.
DR PROSITE; PS01201; TUB_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 30..82
FT /note="Tubby N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16322"
FT DOMAIN 84..195
FT /note="Tubby N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16322"
FT DOMAIN 216..459
FT /note="Tubby C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01167"
FT REGION 29..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..47
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..118
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 464 AA; 51682 MW; A7A48902608306CE CRC64;
MEASCRRPGP RGDSAFEDET MKLRQLKLDN QRALLEKKQR KKRLEPLMVQ PNPEARPRRS
RPRGSEEHTP LVEPQALHDG VVLHGIDGPA AFLKPDAQDS ESGLHVLSVG SSVTEEEPEG
SASGEKTGGP ASKPDLQDIL QRHGISGSLN FDEEDTDGEE EEGKKLSSHS PNSEAERPSS
ASSQKPTTDT AASGTAAQQT DNQLGEIDNL EGFAYSPAPR GVTVKCRITR DKKGMDRGLF
PTYYMHLEKD ENRKVFLLAG RKRKKSKTSN YLISTDPTDL SREGESYIGK LRSNLMGTKF
TVYDHGVSPT KAQGLVEKTY TRQELAAVCY ETNVLGFKGP RKMSVIIPGM NMNHERIPFQ
PRNDHESLLS KWQNKTMDNL IELHNKSPVW NDDTQSYVLN FHGRVTQASV KNFQIVHESD
PDYIVMQFGR VADDVFTLDY NYPLCALQAF AIGLSSFDSK LACE
//
