ID A0A287CSV6_ICTTR Unreviewed; 1242 AA.
AC A0A287CSV6;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Spectrin beta, non-erythrocytic 4 {ECO:0000313|Ensembl:ENSSTOP00000024357.1};
GN Name=SPTBN4 {ECO:0000313|Ensembl:ENSSTOP00000024357.1};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000024357.1, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000024357.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the spectrin family.
CC {ECO:0000256|ARBA:ARBA00006826}.
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DR EMBL; AGTP01088977; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01088978; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01088979; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01088980; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01088981; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01088982; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01088983; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A287CSV6; -.
DR Ensembl; ENSSTOT00000041971.1; ENSSTOP00000024357.1; ENSSTOG00000021798.2.
DR GeneTree; ENSGT00940000156343; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0043226; C:organelle; IEA:UniProt.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.
DR CDD; cd10571; PH_beta_spectrin; 1.
DR CDD; cd00176; SPEC; 4.
DR Gene3D; 1.20.58.60; -; 5.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041681; PH_9.
DR InterPro; IPR001605; PH_dom-spectrin-type.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF232; SPECTRIN BETA CHAIN, NON-ERYTHROCYTIC 4; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF15410; PH_9; 1.
DR Pfam; PF00435; Spectrin; 8.
DR PRINTS; PR00683; SPECTRINPH.
DR SMART; SM00233; PH; 1.
DR SMART; SM00150; SPEC; 8.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 5.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Actin capping {ECO:0000256|ARBA:ARBA00022467};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1096..1205
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 529..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 866..1101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1213..1242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 121..148
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 339..366
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 905..991
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1019..1041
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1242 AA; 140575 MW; C3789E7A15D3DEDA CRC64;
MLMARDGSRE DGHKLHKRWL RHQAFMAELA QNKEWLEKIE REGQQLMQEK PELAASVRKK
LGEIRQCWAE LESTTQAKAR QLFEASKADQ LVQSFAELDK KLLHMESQLQ DVDPGGDLAT
VNSQLKKLQS MESQVEEWYR EVGELQAQTA ALPLEPASKE LVGERQNAVG ERLVRLLEPL
QERRRLLLAS KELHQVAHDL DDELAWVQER LPLAMQTERG SGLQAVQQHI KKNQGLRREI
QAHGPRLEEV LERAGALASL RSPEAEAVRR GLEQLQSAWA GLREAAERRQ QVLDAAFQVE
QYYFDVAEVE AWLGEQELLM MSEDKGKDEQ STLQLLKKHL QLEQGVENYE ESIAQLSRQC
RALLEMGHPD SEQISRRQSQ VDRLYVALKE LGEERRVGLE QQYWLYQLSR QVDELEHWIA
EKEVVAGSPE LGQDFEHVSV LQEKFSEFAS ETGTAGRERL AAVNQMVDEL IECGHTAAAT
MAEWKDGLNE AWAELLELMG TRAQLLAASR ELHKFFSDAR ELQGQIEEKR RRLPRLTAPP
EPRPSASSMQ RTLRAFEHDL QLLVSQVRQL QEGAAQLRTV YAGEHAEAIA SREQEVLQGW
KELLAACEDA RLHVSSTADA LRFHSQARDL LSWMDGIAGQ IGAADKPRDV SSVEVLMNYH
QGLKTELEAR VPELTACQEL GRSLLLNKSA MADEIQAQLD KLGTRKEEVS DKWDRHWEWL
QQMLEVHQFA QEAVVADAWL TAQEPLLQSR ELGSSVDEVE QLIRRHEAFR KAAAAWEERF
SSLRRLTTIE KIKAEQSKQP PTPLLGRKFF GDPTELAAKA APLLRPGGYE RGLEPLARRA
SDTLSAEVRT RVGYVRQELK PERLQPRIDR LPEVPGRVEP AAPPAAPENI AAETPGTPAA
AEQVRPRPER QESADRTEEL PRRRRPERQE SADQPEESAR RRRPERQESA EHEVAHSLTL
GRYEQMERRR ERRERRLERQ ESSEQETPVR GELAKGKATL ADIVEQLQEK EAGPGLPVGV
PSLPQPRELP PGRLPNGLEP PERTPRPDRP RARDRPKPRR RPRPREGGEG GGSRRSRSAP
AQGGSAPAPP PPPTHTVQHE GFLLRKRELD ANRKSSNRSW VSLYCVLSKG ELGFYKDSKG
PASGGTHGGE PLLSLHKATS EVASDYKKKK HVFKLQTQDG SEFLLQAKDE EEMNGWLEAV
AASVTEHAEI ARWGQTLPTT SSTDEGNPKR EGGERRASGR RK
//
