ID A0A287CTL0_ICTTR Unreviewed; 1704 AA.
AC A0A287CTL0;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Polybromo 1 {ECO:0000313|Ensembl:ENSSTOP00000024609.1};
GN Name=PBRM1 {ECO:0000313|Ensembl:ENSSTOP00000024609.1};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000024609.1, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000024609.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AGTP01005616; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01005617; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01005618; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_013217040.1; XM_013361586.1.
DR Ensembl; ENSSTOT00000032632.1; ENSSTOP00000024609.1; ENSSTOG00000000351.3.
DR eggNOG; KOG1827; Eukaryota.
DR GeneTree; ENSGT00390000003017; -.
DR OrthoDB; 2878065at2759; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0016586; C:RSC-type complex; IEA:InterPro.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR CDD; cd04717; BAH_polybromo; 2.
DR CDD; cd05524; Bromo_polybromo_I; 1.
DR CDD; cd05517; Bromo_polybromo_II; 1.
DR CDD; cd05520; Bromo_polybromo_III; 1.
DR CDD; cd05518; Bromo_polybromo_IV; 1.
DR CDD; cd05515; Bromo_polybromo_V; 1.
DR CDD; cd05526; Bromo_polybromo_VI; 1.
DR CDD; cd21984; HMG-box_PB1; 1.
DR Gene3D; 2.30.30.490; -; 2.
DR Gene3D; 1.20.920.10; Bromodomain-like; 6.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR037968; PBRM1_BD5.
DR InterPro; IPR037382; Rsc/polybromo.
DR PANTHER; PTHR16062:SF19; PROTEIN POLYBROMO-1; 1.
DR PANTHER; PTHR16062; SWI/SNF-RELATED; 1.
DR Pfam; PF01426; BAH; 2.
DR Pfam; PF00439; Bromodomain; 6.
DR Pfam; PF00505; HMG_box; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00439; BAH; 2.
DR SMART; SM00297; BROMO; 6.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47370; Bromodomain; 6.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS51038; BAH; 2.
DR PROSITE; PS00633; BROMODOMAIN_1; 5.
DR PROSITE; PS50014; BROMODOMAIN_2; 6.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT DOMAIN 64..134
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 200..270
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 400..470
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 553..623
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 691..761
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 832..877
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 971..1089
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT DOMAIN 1171..1287
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT DOMAIN 1394..1462
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 1394..1462
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 155..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 292..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 487..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 640..668
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 917..956
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1338..1393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1446..1475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..654
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 917..948
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1355..1385
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1704 AA; 194815 MW; 9BB7CC3B149DC9FC CRC64;
MGSKRRRATS PSSSVSGDFD DGHHSVSTPG PSRKRRRLSN LPTVDPIAVC HELYNTIRDY
KDDQGRLLCE LFIRAPKRRN QPDYYEVVSQ PIDLMKIQQK LKMEEYDDVN LLTADFQLLF
NNAKAYYKPD SPEYKAACKL WDLYLRTRNE FVQKGEADDE DDDEDGQDNQ GAVTEGSSPS
YLKEILEQLL EAIVVATNPS GRLISELFQK LPSKVQYPDY YAIIKEPIDL KTIAQRIQNG
SYKSIHAMAK DIDLLAKNAK TYNEPGSQVF KDANSIKKIF YMKKAEIEHH EMAKSSLRMR
TPSNLSATRL TGPSHSKGSL GEERNTTSKY YRNKRAVQGG RLSAITMALQ YGSESEEDAA
LAAARYEEGE SEAESITSFM DVSNPFYQLY DTVRSCRNNQ GQLIAEPFFH LPSKKKYPDY
YQQIKMPISL QQIRTKLKNQ EYETLDHLEC DLNLMFENAK RYNVPNSAIY KRVLKLQQVM
QTKKKELARR DDIEDGDSMI SSATSDTGSA KRKRNTHDSE MLGLRRLSSK KNIRKQRMKI
LFNVVLEARE PGSGRRLCDL FMVKPSKKDY PDYYKIILEP MDLKIIEHNI RNDKYAGEEG
MIEDMKLMFR NARHYNEEGS QVYNDAHILE KLLKDKRKEL GPLPDDDDIT SPKLKLSRKS
GVSPKKSKYM TPMQQKLNEV YEAVKNYTDK RGRRLSAIFL RLPSRSELPD YYLTIKKPMD
MEKIRSHMMA NKYQDIDSMV EDFVMMFNNA CTYNEPESLI YKDALVLHKV LLETRRDLEG
DEDSHVPNVT LLIQELIHNL FVSVMSHQDD EGRCYSDSLA EIPGVDPTFP NKPPLTFDII
RKNVENNRYR RLDLFQEHMF EVLERARRMN RTDSEIYEDA VELQQFFIRI RDELCKNGEI
LLSPALSYTT KHLHNDVEKE KKEKLPKEIE EDKLKREEEK REAEKSEDSS GATGLSGLHR
TYSQDCSFKN SMYHVGDYVY VEPAEANLQP HIVCIERLWE DSAGEKWLYG CWFYRPNETF
HLATRKFLEK EVFKSDYYNK VPVNKILGKC VVMFVKEYFK LCPESFRDED VFVCESRYSA
KTKSFKKIKL WTMPISSVRF VPRDVPLPVV RVASVFANAD KGDDEKNTDN SEDSRVEDNF
NLEKEKEDVP VEMSNGEPGC HYFEQLRYND MWLKVGDCVF IKSHGLVRPR VGRIEKVWVR
DGAAYFYGPI FIHPEETEHE PTKMFYKKEV FLSNLEETCP MTCILGKCAV LSFKDFLSCR
PTEIPENDIL LCESRYNESD KQMKKFKGLK RFSLSAKVVD DEIYYFRKPI VPQKEPSPLL
EKKIQLLEAK FAELEGGDED VEEMGEEDSE VIEPPSLPQL QTPLSSELDL MPYTPPQSTP
KSAKGSAKKE GSKRKINMSG YILFSSEMRA VIKAQHPDYS FGELSRLVGT EWRNLETAKK
AEYEERAAKV AEQQERERAA QQQQPSASPR AGTPVGALMG VVPPPTPMGM LNQQLTPVAG
MMGGYPPGLP PLQGPVDGLV SMGSMQPLHP GGPPPHHLPP GVPGLPGIPP PGVMNQGVAP
MVGTPAPGGS PYGQQVGVLG PPGQQAPPPY PGPHPTGPPV IQQPTTPMFV APPPKTQRLL
HSEAYLKYIE GLSAESNSIS KWDQTLAARR RDVHLSKEQE SRLPSHWLKS KGAHTTMADA
LWRLRDLMLR DTLNIRQAYN LENV
//
