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Database: UniProt
Entry: A0A287CV73_ICTTR
LinkDB: A0A287CV73_ICTTR
Original site: A0A287CV73_ICTTR 
ID   A0A287CV73_ICTTR        Unreviewed;      1019 AA.
AC   A0A287CV73;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   31-JUL-2019, entry version 13.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000025179};
GN   Name=DROSHA {ECO:0000313|Ensembl:ENSSTOP00000025179};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)
OS   (Spermophilus tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha;
OC   Sciuridae; Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000025179, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Ensembl:ENSSTOP00000025179, ECO:0000313|Proteomes:UP000005215}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000025179}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2017) to UniProtKB.
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DR   EMBL; AGTP01040647; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01040648; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01040649; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01040650; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01040651; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01040652; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01040653; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01040654; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01040655; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01040656; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 43179.ENSSTOP00000014621; -.
DR   Ensembl; ENSSTOT00000041097; ENSSTOP00000025179; ENSSTOG00000016323.
DR   GeneTree; ENSGT00730000111052; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0070877; C:microprocessor complex; IEA:Ensembl.
DR   GO; GO:0014069; C:postsynaptic density; IEA:Ensembl.
DR   GO; GO:0017151; F:DEAD/H-box RNA helicase binding; IEA:Ensembl.
DR   GO; GO:0001530; F:lipopolysaccharide binding; IEA:Ensembl.
DR   GO; GO:0070878; F:primary miRNA binding; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0070412; F:R-SMAD binding; IEA:Ensembl.
DR   GO; GO:0004525; F:ribonuclease III activity; IEA:Ensembl.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:Ensembl.
DR   GO; GO:0010586; P:miRNA metabolic process; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0031054; P:pre-miRNA processing; IEA:Ensembl.
DR   GO; GO:0031053; P:primary miRNA processing; IEA:Ensembl.
DR   GO; GO:0050727; P:regulation of inflammatory response; IEA:Ensembl.
DR   GO; GO:2000628; P:regulation of miRNA metabolic process; IEA:Ensembl.
DR   GO; GO:0045589; P:regulation of regulatory T cell differentiation; IEA:Ensembl.
DR   GO; GO:0016075; P:rRNA catabolic process; IEA:InterPro.
DR   CDD; cd00048; DSRM; 1.
DR   CDD; cd00593; RIBOc; 2.
DR   Gene3D; 1.10.1520.10; -; 1.
DR   HAMAP; MF_00104; RNase_III; 1.
DR   InterPro; IPR014720; dsRBD_dom.
DR   InterPro; IPR011907; RNase_III.
DR   InterPro; IPR000999; RNase_III_dom.
DR   InterPro; IPR036389; RNase_III_sf.
DR   Pfam; PF00035; dsrm; 1.
DR   Pfam; PF14622; Ribonucleas_3_3; 1.
DR   Pfam; PF00636; Ribonuclease_3; 1.
DR   SMART; SM00358; DSRM; 1.
DR   SMART; SM00535; RIBOc; 2.
DR   SUPFAM; SSF69065; SSF69065; 2.
DR   PROSITE; PS50137; DS_RBD; 1.
DR   PROSITE; PS00517; RNASE_3_1; 2.
DR   PROSITE; PS50142; RNASE_3_2; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005215};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266}.
FT   DOMAIN      521    701       RNase III. {ECO:0000259|PROSITE:PS50142}.
FT   DOMAIN      752    878       RNase III. {ECO:0000259|PROSITE:PS50142}.
FT   DOMAIN      905    979       DRBM. {ECO:0000259|PROSITE:PS50137}.
FT   REGION        1     28       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION       94    139       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COILED      456    476       {ECO:0000256|SAM:Coils}.
FT   COILED      990   1010       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS     94    120       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    121    135       Acidic. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   1019 AA;  118210 MW;  19D1AD3B5CB5E7CA CRC64;
     MSFHPGRGCP RGRGGHGTRP SAPAFRPQNL RLLHPQQPPV QYQYEPPKLL KPVWIRCTHS
     ENYYSSDPMD QVGDSTVVGT SRLRDLYDKF EEELGSRQEK AKAARPPWEP PKTKLDEDLE
     SSSESECESD EDSTCSSSSD SEVFDVIAEI KRKKAHPDRL HDELWYNDPG QVRAFLCPCY
     EGCKPTRHIY GSGLRRCMLA GAIKPCRPMT NNAGRLFHYR ITVSPPTNFL TDRPTVIEYD
     DHEYIFEGFS MFAHAPLTNI PLCKVIRFNI DYTIHFIEEM MPENFCVKGL ELFSLFLFRD
     ILELYDWNLK GPLFEDSPPC CPRFHFMPRF VRFLPDGGKE VLSMHQILLY LLRCSKALVP
     EEEIANMLQW EELEWQKYAE ECKGMIVTNP GTKPSSVRID QLDREQFNPD VITFPIIVHF
     GIRPAQLSYA GDPQYQKLWK SYVKLRHLLA NSPKVKQTDK QKLAQREEAL QKIRQKNTMR
     REVTVELSSQ GFWKTGIRSD VCQHAMMLPV LTHHIRYHQC LMHLDKLIGY TFQDRCLLQL
     AMTHPSHHLN FGMNPDHARN SLSNCGIRQP KYGDRKVHHM HMRKKGINTL INIMSRLGQD
     DPTPSRINHN ERLEFLGDAV VEFLTSVHLY YLFPSLEEGG LATYRTAIVQ NQHLAMLAKK
     LELDRFMLYA HGPDLCRESD LRHAMANCFE ALIGAVYLEG SLEEAKQLFG RLLFNDPDLR
     EVWLNYPLHP LQLQEPNTDR QLIETSPVLQ KLTEFEEAIG VIFTHVRLLA RAFTLRTVGF
     NHLTLGHNQR MEFLGDSIMQ LVATEYLFIH FPDHHEGHLT LLRSSLVNNR TQAKVAEELG
     MQEYAITNDK TKRPVALRTK TLADLLESFI AALYIDKDLE YVHTFMNVCF FPRLKEFILN
     QDWNDPKSQL QQCCLTLRTE GKEPDIPLYK TLQTVGPSHA RTYTVAVYFK GERIGCGKGP
     SIQQAEMGAA MDALEKYNFP QMAHQKRFIE RKYRQELKEM RWEREHQERE PDETEDIKK
//
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