ID A0A287CWF1_ICTTR Unreviewed; 1779 AA.
AC A0A287CWF1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Myosin heavy chain 14 {ECO:0000313|Ensembl:ENSSTOP00000025603.1};
GN Name=MYH14 {ECO:0000313|Ensembl:ENSSTOP00000025603.1};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000025603.1, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000025603.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; AGTP01115405; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01115406; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01115407; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01115408; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01115409; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01115410; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01115411; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSSTOT00000032972.1; ENSSTOP00000025603.1; ENSSTOG00000024990.2.
DR GeneTree; ENSGT00940000158808; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 3.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.10.250.2420; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF31; MYOSIN-14; 1.
DR Pfam; PF00063; Myosin_head; 2.
DR Pfam; PF01576; Myosin_tail_1; 2.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00015; IQ; 1.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT DOMAIN 1..630
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 514..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 989..1010
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1042..1074
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1374..1404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1687..1723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1745..1779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1687..1714
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1761..1779
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 52..59
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1779 AA; 202941 MW; 2BAEDF4410B62CA4 CRC64;
FCVVINPYKQ LPIYTEAIVE MYRGKKRHEV PPHVYAVTEG AYRSMLQGEC GGESGAGKTE
NTKKVIQYLA HVASSPKGRK EPGVPASAST VSYGELERQL LQANPILEAF GNAKTVKNDN
SSRFGKFIRI NFDVAGYIVG ANIETYLLEK SRAIRQAKDE CSFHIFYQLL GGAGEQLKAD
LLLEPCSNYR FLTNGPSSSP GQERELFQET LESLRVLGFA PEEITSMLRT VSAVLQFGNV
VLKSERNTDQ ATMPDNTAAQ KLCRLLGLGV TDFSRALLTP RIKVGRDYVQ KAQSKEQADF
ALEALAKATY ERLFRWLVLR LNRALDRSPR QGASFLGILD IAGFEIFQLN SFEQLCINYT
NEKLQQLFNH TMFVLEQEEY QREGIPWTFL DFGLDLQPCI DLIERPANPP GLLALLDEEC
WFPKATDKSF VEKVAQEQGS HPKFQRPRHL RDQADFSVLH YAGKVDYKAN EWLMKNMDPL
NDNVAALLHQ STDRLTAEIW KDEHGGLQQL SFLGSFPPSP PGSAGRRGSD TPLPGGGCPC
ASTGEAAGQG GWTGIRICRQ GFPNRILFQE FRQRYEILTP NAIPKGFMDG KQACEKMIQA
LELDPNLYRV GQSKIFFRAG VLAQLEEERD LKVTDIIVSF QAAARGYLAR RAFQRRQQQQ
SALRVMQRNC AAYLKLRHWQ WWRLFIKVKP LLQVTRQDEV LQARAQELQK VQELQQQSAR
ELEEERTRLA EQLRAEAELC AEAEETRGRL AARKQELELV VSELEARMGE EEECSRQLQT
EKKRLQQHIQ ELETHLEAEE GARQKLQLEK VTTEAKLKKF EEDLLLLEDQ NAKLSKERRL
LEERLAEFSS QAAEEEEKVK SLNKLRLKYE ATIADMEDRL RKEEKGRQEL EKLKRRLDGE
SSELQEQMVE QQQRAEELRA QLGRKEEELQ AALARAEEEG GARAQLLKSL REAQAGLAEA
QEDLEAERAA RAKAEKQRRD LGEELEALRG ELEDTLDSTN AQQELRSKRE QEVTELKKAL
EEETRVHEVA EVSELRAELS SLQTARQEGE QKRRRLESQL QEVQGRAGDG ERARVEAAEK
LQRAQAELEN VSGALSEAES KAIRLGKELS STEAQLHDTQ ELLQEETRAK LALGSRVRAV
EAEVAGLREQ LEEEAAARER AGRELQTAQA QLADWRRRQE EEAGALEAGE EARRRAAREA
EALAQRLAEK TEAVERLERG RRRLQQELDD VTVDLEQQRQ LVSTLEKKQR KFDQLLAEEK
AAVLRAVEER ERVEAEGRER EARALSLTRA LEEEQEAREE LERQNRALRA ELEALLSSKD
DVGKSVHELE RARRVAEQAA SDLRTQVTEL EDELTAAEDA KLRLEVTVQA LKTQHERDLQ
GRDEAGEERR RQLAKQLRDA EVERDEERKQ RALAVAARKK LEAELEELKA QTTAAGQGKE
EAVKQLRKMQ AQMKELWREV EESRSSREEI FVQSRESEKR LKALEAEVLR LQEELAASDR
ARRQAQQDRD EMADEVANGN LSKAAILEEK RQLEGRLGQM EEELEEEQSN AELLNDRYRK
LLLQVETLTT ELSAERSFSA KAESGRQQLE RQIQELRGRL GEEDAGARAR QKMVIAALES
KLAQAEEQLE QESRERILSG KLVRRAEKRL KEVVMQVEEE RRVADQLRDQ LEKGNLRVKQ
LKRQLEEAEE EASRAQAGRR RLQRELEDVT ESAESMNREV TTLRNRLRRG PLTFTTRTVR
QVFRLEKGVA SDEEEAQEAE PGSGPPPPEP EGPPPAQPQ
//
