ID A0A287CXA3_ICTTR Unreviewed; 4406 AA.
AC A0A287CXA3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Vacuolar protein sorting 13 homolog D {ECO:0000313|Ensembl:ENSSTOP00000025889.1};
GN Name=VPS13D {ECO:0000313|Ensembl:ENSSTOP00000025889.1};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000025889.1, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000025889.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the VPS13 family.
CC {ECO:0000256|ARBA:ARBA00006545}.
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DR EMBL; AGTP01006928; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01006929; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01006930; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01006931; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 43179.ENSSTOP00000025889; -.
DR Ensembl; ENSSTOT00000030737.1; ENSSTOP00000025889.1; ENSSTOG00000005519.3.
DR GeneTree; ENSGT00950000183083; -.
DR InParanoid; A0A287CXA3; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0007005; P:mitochondrion organization; IEA:Ensembl.
DR GO; GO:1901526; P:positive regulation of mitophagy; IEA:Ensembl.
DR CDD; cd14306; UBA_VP13D; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR041969; VP13D_UBA.
DR InterPro; IPR026847; VPS13.
DR InterPro; IPR026854; VPS13-like_N.
DR InterPro; IPR049424; VPS13_C.
DR InterPro; IPR031645; VPS13_DH-like.
DR InterPro; IPR031646; VPS13_extend_chorein.
DR InterPro; IPR031642; VPS13_mid_RBG.
DR InterPro; IPR009543; VPS13_VAB.
DR PANTHER; PTHR16166:SF141; INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13D; 1.
DR PANTHER; PTHR16166; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13; 1.
DR Pfam; PF12624; Chorein_N; 1.
DR Pfam; PF00627; UBA; 1.
DR Pfam; PF21679; VPS13_C; 1.
DR Pfam; PF16909; VPS13_DH-like; 1.
DR Pfam; PF16908; VPS13_ext_chorein; 1.
DR Pfam; PF16910; VPS13_mid_rpt; 2.
DR Pfam; PF06650; VPS13_VAB; 1.
DR SMART; SM00165; UBA; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50030; UBA; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 2651..2694
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT REGION 406..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 743..796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1742..1773
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2094..2125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2144..2165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 100..127
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 743..759
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2146..2162
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4406 AA; 493053 MW; 9248D3C182BE078F CRC64;
MLEGLVAWVL NTYLGKYVNN LNTDQLSVAL LKGAVELENL PLKKDALKEL ELPFEVKAGF
IGKVTLQIPF YRPHVDPWVI SISSLHLIGA PEKIQDFNDE KEKLLERERK KALLQALEEK
WKNERQQKGE SYWYSVTASV VTRIVENIEL KIQDVHLRFE DGVTNPSHPF AFGICIKNVS
MQNAVNEPVQ KLMRKKQLDV AEFGTYWDVD CTLLGDLPQV ELQEAMARSM ESRSHHYVLE
PVCASALLKR NCSKEPLRSR HSPRIECDIQ LETIPLKLSQ LQYRQIMGFL KELERKERQV
KFRKWKPKVA VSKSCREWWY FALNANLYEI REQRKRCTWD FLLHRAHDAV FYTDKYFSKL
KGGLLSAEDK EEMCRIEEEQ SFEELKILRE LVHDRFYKQE ELAESLREPQ FDSPGSSPGD
PDASGGSGML QYLQSWFPGW GGWYGQQNPE GRAVEGLPAE QQEQWTPEEI LGTEEFFDPT
ADASCMNTYT KRDHVFAKLN LQLQRGTVTL LHMEQGDPQM SESAFMQLEF SDVKLLAESL
PRRNSSLLLV RLGGLFLRDL ATEGTMFPLL VFPNPQKEVG RVSQSFGLQT TSADRSDQYP
AADTDDPVFE MLYERNPVHS HFERRLNVST RPLNIIYNPQ AIKKVADFFY KGKVHTSGFG
YQSELELRVA EAARRQYNKL KMQTKAEIRQ TLDRLLVGDF IEESKRWTVR LDISAPQVIF
PDDFKFKNPV LVVVDLGRML LTNSQDDSNR TSGDGSASEE NQFSDDEYKT PLATPPNTPP
PETSSSNGEK TPPFPGVEIS EEQLQAHLMN TKMYEKYALS FMDLQIMVGR VKDNWKHVQD
IDVGPTHVVE KFNVHLQLER RLIYTSDPKY PGAVLSGNLP DLKIHINEDK ISALKNCFAL
LTTPEMKTSD TQIKEKIFPQ EEQRGSLQDS VMNLTQSIVM LEQHTREVLV ESQLLLAEFK
VNCMQLGVES NGRYISVLKV FGTNAHFVKR PYDAEVSLTV HGLLLVDTMQ TYGADFDLLM
ASHKNLSFDI PTGSLRDSRA QSPVSGPNVA SLTDVATLND RSATSVSLDK ILTKEQESLI
KLEYQFVSSE CPSMNLDSTL QVISLQVNNL DIILNPETIV ELIGFLQKSF PKEKDDLSPQ
PLMTDFERSF REQGTYQSTY EQNTEVAVEI HRLNLLLLRT VGMANGEKHG RKIATASVGG
TKVNVSMGST FDVNGSLGCL QLMDLTQDNV KNQYVVSIGN SAGYENIVSD IGYFESVFVR
MEDAALTEAL SFTFVEKSKQ ECFLNLKMAS LHYNHSAKFL KELTLSMDEL EENFRSMLKS
AATKVTTVLA TKTAEYSEMV SLFETPKKSR EPFILEENEI YGFGLTSCHS DTVKLILNIY
IESPVVSIPR KPGSPELLVG HLGQIFIQNF VAGDDESRSD RLQVESKDIK LYSLNCTQLA
GREGAGAEVN RTFCSPSGSA SANSQEEAHF TRHDFFESLH RGQAFHILNN TTIQFKLEKI
PIERESELTF SLSPDDLGTS SIMKIEGKFV NPVQVVLAKH VYEQVLQTLD NLVYSEDLNK
FPASVASSSC PNSPVPALSA CGEPSLERKE NGLFSHSSLS STSQKSLSVR EAKAFTQIQA
NFCISELQVQ LSGDLTLGAQ GLVSLRFQDF EVEFSKDHPQ TLSIQIALRS LLMEDLLEKN
PDSKYKNLMV SRGAPKPSSL AQKEYLSQSC PSVSNVEYPD MPRSLPSHME EAPNVFQLYQ
RPTSVSRKKQ KEVQDKDYPL TPPPSPTIDE PKVVTGKSKF DDSLVHINIF LVDKKHPEFS
SIYNRVNRSI DVDFNCLDVL ITLQTWVVIL DFFGIGSTAD NHAMKLPPED VLQNVKVESS
AFTAPELQDP VNTKLDLKVH SLSLVLNKTT SELAKANVSK LVAHLEMIEG DLALQGSIGS
LSLSDLTSHG ELYRERFTTS GEEALIFQAF KYGQPDPLLR REHDVRVSLQ MASVQYVHTQ
RFQAEVLAFI QHFTQLQDVL GRQRAAVEGQ TVRDQAQRSS RILLDIEAGA PVLLIPESSR
SNKLIVANLG KLKVKNKFLF AGFPGTFSLQ DKDLILSGSA YKDRFFFKES VPVASPASPM
GTPRHSTRKT TSTEDPRGSH SQGLFTMPPA EMVLGSLKNE CVPSVPTKHR GQQATPSVRH
GSSSPEDHVC LLDCVVVDLQ DMDLFAAERC PREYPGTSED RSGDLIFPSY FVRQTGGSLL
TEPCRLKLQV ERNLDKEISH TVPDISIHGS LSSVHCSLDL YKYKLIRGLL ENNLGEPIEE
FMRPYDLQDP RIHTVLSGEV YTCMCFLIDM VNVSLELKDP KGKEGAASLA RFDFKKCKLL
YESFSNQTKS INLVSHSMMA FDTRYAGQKC SPGVSNVFNC IFQPSKNSST PQGSIQIELH
FRSTKDSSCF TVVLNNLRVF LIFDWLLLVH DFLHTPSDIK KQNVTPSHHR NSSSESAVVP
KTVKSGVVTK RSSLPVSNER HLEVKINVTG TEFVVVEDVS CFDTNAIILK GTTVLTYKPR
FVDRPFSGSL FGIEVFSCRL GNEQETALSI VDPVQIQVEL VGNSSYQNSS GLMDAFNSED
FPPVLEIQLQ ALDIRLSYND VQLFLAIAKS IPEQASAAVP DSVAVEAESI GSHLPGAWRV
GEETREGARR TLDPVLELQL ARLQELGFSM DDCRKALLVC QGQLKKAASW LFKNAEPLRS
LSLAPSSREG PGAVPAPRIS GVEIKAENVC ICFIDDCMDC DVPLAEITFS RLNFLQHVRT
SPEGYAHFTL SGDYYNRALS GWEPFIEPWP CSVSWQQQAA SRLHPPRLKL EAKAKPRLDI
NITSVLIDQY VSTKESWMAD YCKEDKEIES TQSEEWMGSS VDPPCFGQSL PLVYLRTRST
ASLTNLEHQT YAGEVKTPKR RQPFVPFALR NHTGCTLWFA TLTTTPTRAA LSHSGSPGVV
PEGNGAFLDD AHKVSEWREV LTGEEIPFEF EARGKLRHRH THDLRIHQLQ VRVNGWEQVS
PVSVDKVGTF FRYAAPDKNS SSSTIGSPSS RTNIIHPQVY FSSLPPVRVV FAVTMEGSAR
KVITVRSALI VRNRLETPME LRLDSPSAPD KPVVLPAIMP GDSFAVPLHL TSWRLQARPK
GLGVFFCKAP IHWTNVVKTA EVSSSKRECH SMDTEKSRFF RFCVAIKKEN YPDYMPSNIF
SDSAKQIFRQ PGHTIYLLPT VVICNLLPCE LDFYVKGMPI NGTLKPGREV ALHTADTSQN
IELGVSLENF PLCKELLIPP GTQNYMVRMR LYDINRRQLN LTIRIVCRAE GSLKIFISAP
YWLINKTGLP LIFRQDNAKT DAAGQFEEHE LARSLSPLLF CYADKEQPNL CTMRIGRGIH
PEGMPGWCQG FSLDGGSGVR ALKVIQQGNR PGLIYNIGID VKKGRGRYID TCMVIFAPRY
LLDNKSSHKL AFAQREFARG QGTANPEGYI STLPGSSVVF HWPRNDYDQL LCVRLMDVPN
CIWSGGFEVN KNNSFHINMR DTLGKCFFLR VEITLRGATY RISFSDTDQL PPPFRIDNFS
KVPVVFTQHG VAEPRLRTEV KPMTSLDYAW DEPTLPPFIT LTVKGAGSSE ISCNMNDFQD
NRQLYYENFI YIAATYTFSG LQEGTGRPGS ANKAITCAEL VLDVSPKTQR VILKKKEPGK
RSQLWRMTGT GMLAHEGSSV PHNPNKPSAT RSMEGSAILD IAGLAAVTDN RYEPLMLRKP
DRRRSTTQTW SFREGKLTCG LHGLVVQAKG GLSGLFDGAE VVLGPDTSVE LLGPVPPEQQ
FINQKMRPGS GMLSIRVIPD GPTRALQITD FCQRKSDRSS CEVDELPVTE QELQKLRNPD
TEQELEVLVR LEGGIGVSLI NKVPEELVFA SLTGINVHYT QLATSHVLEL SIQDVQVDNQ
LIGTTQPFML YVTPLSNENE VIETGPAVQV NAVKSPSKSA LTNIYKHLMV TAQRFTVQIE
EKLLLKLLSF FGYDQAESEV EKYDENLHEK TAEQGGTPTR YYFENLKISI PQIKLSVFTS
NKLPLDLKAL KSTLGFPLIR FEDAVINLDP FTRVHPYETK EFIINDILKH FQEELLSQAA
RILGSVDFLG NPMGLLNDVS EGVTGLIKYG NVGGLIRNVT HGVSNSAAKF AGTLSDGLGK
TMDNRHQSER EYIRYHAATS GEHLVAGIHG LAHGIIGGLT SVITSTVEGV KTEGGVSGFI
SGLGKGLVGT VTKPVAGALD FASETAQAVR DTATLSGPRT QAQRVRRPRC CTGPQGLLPR
YSESQAEGQE QLFKLTDNIQ DEFFIAVENI DSYCVLISSK AVYFLKSGDY VDREAIFLEV
KYDDLYHCLV SKDHGKVYVQ VTKKAASTSS GVSIPGPSHQ KPMVHVKSEV LAVKLSQEIN
YAKSLYYEQQ LMLRLSENQE QLELDS
//
