ID A0A287CXB4_ICTTR Unreviewed; 2646 AA.
AC A0A287CXB4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Teneurin transmembrane protein 1 {ECO:0000313|Ensembl:ENSSTOP00000025970.1};
GN Name=TENM1 {ECO:0000313|Ensembl:ENSSTOP00000025970.1};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000025970.1, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000025970.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the tenascin family. Teneurin subfamily.
CC {ECO:0000256|ARBA:ARBA00009385}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AGTP01013191; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01013192; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01013193; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01013194; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01013195; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01013196; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01013197; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01013198; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01013199; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01013200; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSSTOT00000040911.1; ENSSTOP00000025970.1; ENSSTOG00000000440.3.
DR GeneTree; ENSGT01030000234566; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR Gene3D; 2.180.10.10; RHS repeat-associated core; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR031325; RHS_repeat.
DR InterPro; IPR009471; Ten_N.
DR InterPro; IPR028916; Tox-GHH_dom.
DR InterPro; IPR006530; YD.
DR NCBIfam; TIGR01643; YD_repeat_2x; 3.
DR PANTHER; PTHR11219; TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR PANTHER; PTHR11219:SF7; TENEURIN-1; 1.
DR Pfam; PF05593; RHS_repeat; 1.
DR Pfam; PF06484; Ten_N; 1.
DR Pfam; PF15636; Tox-GHH; 1.
DR SMART; SM00181; EGF; 8.
DR SUPFAM; SSF63829; Calcium-dependent phosphotriesterase; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR PROSITE; PS00022; EGF_1; 5.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS51361; TENEURIN_N; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 239..264
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..239
FT /note="Teneurin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51361"
FT DOMAIN 513..545
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 579..612
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 643..674
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 682..717
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 120..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 535..544
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 602..611
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 647..657
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 664..673
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 686..696
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 707..716
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2646 AA; 295914 MW; C0060D97133BCF64 CRC64;
HWGGGTKPFC LQSLSRICWC YKQSLDIYYV SPVEERWLST TIVISFQRGL IGVFLIGPNL
THCLYVILSE ILVSLSCCIS QTAKKESKSL FCVFLNSFLE MQSSPHNQFT FRPLPPPPPP
PHACTCARKP PPTADSLQRR SMTTRSQPSP AAPAPPTSTQ DSVHLHNSWV LNSNIPLETR
HFLFKHGSGS SAIFSAASQN YPLTSNTVYS PPPRPLPRST FSRPAFTFNK PYRCCNWKCT
ALSATAITVT LALLLAYVIA VHLFGLTWQL QPVEGQLYEN GISKGNRGTE SMDTTYSPIG
GKVSDKSEKK VFQKGRAIDT GEVDIGAQVM QTIPPGLFWR FQITIHHPIY LKFNISLAKD
SLLGIYGRRN IPPTHTQFDF VKLMDGKQLM KQDSKSSDDT QHSPRNLILT SLQETGFIEY
MDQGPWYMAF YNDGKKVEQV FVLTTAIEIM DDCSTNCNGN GECISGHCHC FPGFLGPDCA
RDSCPVLCGG NGEYEKGHCV CRNGWKGPEC DVPEEQCIDP TCFGHGTCIM GVCICVPGYK
GEICEEEDCL DPMCSSHGIC VKGECHCSTG WGGVNCETPL PICQEQCSGH GTFLLDSGVC
NCDPKWTGSD CSTELCTMEC GSHGVCSRGI CQCEEGWVGP TCEERSCHSH CAEHGQCKDG
KCECSPGWEG DHCTIAHYLD AVRDGCPGLC FGNGRCTLDQ NGWHCVCQVG WSGTGCNVVM
EMLCGDNLDN DGDGLTDCVD PDCCQQSNCY ASPLCQGSPD PLDLIQQSQP LFSQHTSRLF
YDRIKFLIGK DSTHVIPPEI SFDSRRACVI RGQVVAVDGT PLVGVNVSFL HHSDYGFTIS
RQDGSFDLVA IGGISVILIF DRSPFLSEKR TLWLPWNQFV VVEKVIMQRV VPDPPSCDIS
NFVSPNPIVL PSPLTSFGGS CPERGTIVPE LQVVQEEIPI PSSFVRLSYL SSRTPGYKTL
LRILLTHSTI PVGMIKVHLT VAVEGRLTQK WFPAAINLVY TFAWNKTDIY GQKVWGLAEA
LVSVGYEYET CPDFILWEQR TVILQGFEMD ASNLGGWSLN KHHILNPQSG IIHKGNGENM
FISQQPPVIS TIMGNGHQRS VACTNCNGPA HNNKLFAPVA LASGPDGSVY VGDFNFVRRI
FPSGNSVSIL ELSTSPAHKY YLAMDPVSEL LYLSDTNTRK VYKLKSLVET KDLSKNFEVV
AGTGDQCLPF DQSHCGDGGR ASEASLNSPR GITVDKHGFI YFVDGTMIRR INENAVITTV
IGSNGLTSTQ PLSCDSGMDI TQVRLEWPTD LAVNPMDNSL YVLDNNIVLQ ISENRRVRII
AGRPIHCQVP GIDHFLVSKV AIHSTLESAR AISVSHSGLL FIAETDERKV NRIQQVTTNG
EISIIAGAPT DCDCKIDPNC DCFSGDGGYA KDAKMKAPSS LAVSPDGTLY VADLGNVRIR
TISRNQAHLN DMNLYEIASP ADQELYQFTV NGTHLHTLNL ITRDYVYNFT YNAEGDLGAI
TSSNGNSVHI RRDAGGMPLW LVVPGGQVYW LTISSNGVLK RVSAQGYNLA LMTYPGNTGL
LATKSNENGW TTVYEYDPEG HLTNATFPTG EVSSFHSDLE KLTKVELDTS NRENVLMSTN
LTATSTIYIL KQENTQSTYR VSPDGSLRVT FASGMEISLS SEPHILAGAV NPTLGKCNIS
LPGEHNANLI EWRQRKEQSK GNISAFERRL RAHNRNLLSI DFDHITRTGK IYDDHRKFTL
RILYDQTGRP ILWSPVSRYN EVNITYSPSG LVTFIQRGTW NEKMEYDQSG KIISRTWADG
KIWSYTYLEK SVMLLLHSQR RYIFEYDQSD CLLSVTMPSM VRHSLQTMLS VGYYRNIYTP
PDSSTSFIQD YSRDGRLLQT LHLGTGRRVL YKYTKQARLS EILYDTTQVT LTYEESSGVI
KTIHLMHDGF ICTIRYRQTG PLIGRQIFRF SEEGLVNARF DYSYNNFRVT SMQAVINETP
LPIDLYRYVD VSGRTEQFGK FSVINYDLNQ VITTTVMKHT KIFSANGQVI EVQYEILKAI
AYWMTIQYDN MGRMVICDIR VGVDANITRY FYEYDADGQL QTVSVNDKTQ WRYSYDLNGN
INLLSHGNSA RLTPLRYDLR DRITRLGEIQ YKMDEDGFLR QRGNDIFEYN SNGLLQKAYN
KVSGWTVQYY YDGLGRRVAS KSSLGQHLQF FYADLANPIR VTHLYNHTSS EITSLYYDLQ
GHLIAMELSS GEEYYVACDN TGTPLAVFSS RGQVIKEILY TPYGDIYHDT YPDFQVIIGF
HGGLYDFLTK LVHLGQRDYD VVAGRWTTPN HHIWKQLNLL PKPFNLYSFE NNYPVGKIQD
VAKYTTDIGS WLELFGFQLH NVLPGFPKPE LENLELTYEL LQLQTKTQEW DPGKTILGIQ
CELQKQLRNF ISLDQLPMTP RYNEGRCLEG GKQPRFAAVP SVFGKGIKFA IKDGIVTADI
IGVANEDSRR LAAILNNAHY LENLHFTIEG RDTHYFIKLG SLEEDLVLIG NTGGRRILEN
GVNVTVSQMT SVLNGRTRRF ADIQLQHGAL CFNIRYGTTV EEEKNHVLEI ARQRAVAQAW
TKEQRRLQEG EEGIRAWTEG EKQQLLSTGR VQGYDGYFVL SVEQYLELSD SANNIHFMRQ
SEIGRR
//
