ID A0A287CYI8_ICTTR Unreviewed; 1261 AA.
AC A0A287CYI8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Dynactin subunit 1 {ECO:0000256|ARBA:ARBA00016574};
GN Name=DCTN1 {ECO:0000313|Ensembl:ENSSTOP00000026319.1};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000026319.1, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000026319.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the dynactin 150 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00011010}.
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DR EMBL; AGTP01057538; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A287CYI8; -.
DR Ensembl; ENSSTOT00000037938.1; ENSSTOP00000026319.1; ENSSTOG00000000987.3.
DR GeneTree; ENSGT00940000155378; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR Gene3D; 2.30.30.190; CAP Gly-rich-like domain; 1.
DR InterPro; IPR036859; CAP-Gly_dom_sf.
DR InterPro; IPR000938; CAP-Gly_domain.
DR InterPro; IPR022157; Dynactin.
DR PANTHER; PTHR18916; DYNACTIN 1-RELATED MICROTUBULE-BINDING; 1.
DR PANTHER; PTHR18916:SF6; DYNACTIN SUBUNIT 1; 1.
DR Pfam; PF01302; CAP_GLY; 1.
DR Pfam; PF12455; Dynactin; 1.
DR SMART; SM01052; CAP_GLY; 1.
DR SUPFAM; SSF74924; Cap-Gly domain; 1.
DR PROSITE; PS00845; CAP_GLY_1; 1.
DR PROSITE; PS50245; CAP_GLY_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT DOMAIN 48..90
FT /note="CAP-Gly"
FT /evidence="ECO:0000259|PROSITE:PS50245"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 99..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 937..1028
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 143..173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1261 AA; 139367 MW; EAD9F2DF36084351 CRC64;
MTWGPEKRHG YTPSGSRMSA EASARPLRVG SRVEVIGKGH RGTVAYVGAT LFATGKWVGV
ILDEAKGKND GTVQGRKYFT CDEGHGIFVR QSQIQVFEDG ADTTSPETPD SSTSKVLKRE
GAETAAKTSK LVSGLGPTRP ASTGVAGASS SLGPSGSASA GELSSSEPST PAQTPLAAPI
IPTPALTSPG AAPPLPSPSK EEEGLRAQVR DLEEKLETLR LKRAEDKAKL KELEKHKIQL
EQVQEWKSKM QEQQADLQRR LKEARKEAKE ALEAKERYME EMADTADAIE MATLDKEMAE
ERAESLQQEV EALKERVDEL TTDLEILKAE IEEKGSDGAA SSYQLKQLEE QNARLKDALV
RMRDLSSSEK QEHVKLQKLM EKKNQELEIV RQQRERLQEE LSQAESTIDE LKEQVDAALG
AEEMVEMLTD RNLNLEEKVR ELRETVGDLE AMNEMNDELQ ENARETELEL REQLDMAGAR
VREAQKRVEA AQETVADYQQ TIKKYRQLTA HLQDVNRELT NQQEASVERQ QQPPPETFDF
KIKFAETKAH AKAIEMELRQ MEVAQANRHM SLLTAFMPDS FLRPGGDHDC VLVLLLMPRL
ICKAELIRKQ AQEKFELSEN CSERPGLRGA AGEQLSFAAG LVYSLSLLQA TLHRYEHALS
QCNVDVYKKV GSLYPEMSAH ERSLDFLIEL LHKDQLDETV NVEPLTKAIK YYQHLYSIHL
AEQPEESTMQ LADHIKFTQS ALDCMSVEVG RLRAFLQGGQ EATDIALLLR DLETSCSDIR
QFCKKIRRRM PGTDAPGIPA ALAFGPQVSD TLLDCRKHLT WVVAVLQEVA AAAAQLIAPL
AENEGLPVAA LEELAFKASE QIYGSPSSSP YECLRQSCNI LISTMNKLAT AMQEGEYDAE
RPPSKPPPVE LRAAALRAEI TDAEGLGLKL EDRETVIKEL KKSLKIKGEE LSEANVRLSL
LEKKLDSAAK DADERIEKVQ TRLEETQALL RKKEKEFEET MDALQADIDQ LEAEKAELKQ
RLNSQSKRTI EGLRGPPPSG IATLVSGIAG GVVPGQAPGS LPGPGLVKDS PLLLQQISAM
RLHISQLQHE NSILKGAQMK ASLAALPPLH VAKLSLPPQE GPGGEIAAGA LYRKTSQLLE
TLNQLSTRTH VVDITRTSPA AKSPSAQLME QVAQLKSLSD TIEKLKDEVL KETVSQRPGA
TVPTDFATFP STAFLRAKEE QQDDTVYMGK VTFSCAAGLG QRHRLVLTQE QLHQLHSRLI
S
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