ID A0A287D059_ICTTR Unreviewed; 250 AA.
AC A0A287D059;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=TNF superfamily member 13 {ECO:0000313|Ensembl:ENSSTOP00000026879.1};
GN Name=TNFSF13 {ECO:0000313|Ensembl:ENSSTOP00000026879.1};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000026879.1, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000026879.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670}.
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DR EMBL; AGTP01070906; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005332859.1; XM_005332802.2.
DR AlphaFoldDB; A0A287D059; -.
DR STRING; 43179.ENSSTOP00000026879; -.
DR Ensembl; ENSSTOT00000041935.1; ENSSTOP00000026879.1; ENSSTOG00000034739.1.
DR GeneID; 101977938; -.
DR CTD; 8741; -.
DR eggNOG; ENOG502SAX4; Eukaryota.
DR GeneTree; ENSGT00940000161488; -.
DR InParanoid; A0A287D059; -.
DR OrthoDB; 5358224at2759; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0048298; P:positive regulation of isotype switching to IgA isotypes; IEA:Ensembl.
DR CDD; cd00184; TNF; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR021184; TNF_CS.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR15151; PROTEIN EIGER; 1.
DR PANTHER; PTHR15151:SF12; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13; 1.
DR Pfam; PF00229; TNF; 1.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS00251; TNF_1; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 3: Inferred from homology;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 29..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 117..250
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
SQ SEQUENCE 250 AA; 27729 MW; 20A44F475014931C CRC64;
MPASSPFLLA PKGPSGDMGG PVREPALSVA LWLSWGAALG AVACAIALLT QQTELQSLRR
EVSRLQRNGG PSQKEEGYPW HSLRKQSPEA LEAWASGERS RRRRAVLTQK RKKRHSVLHL
VPINITSKED SDVTEVMWQP ALRRGRGLEA QGYVVRVWDA GVYLLYSQVL FHDVTFTMGQ
VVSREGQGRQ EILFRCICSM PSDPDRAYNS CYSAGVFHLH QGDILSVLIP RAKAKLSLSP
HGTFLGFVKL
//
