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Database: UniProt
Entry: A0A287D0Q8_ICTTR
LinkDB: A0A287D0Q8_ICTTR
Original site: A0A287D0Q8_ICTTR 
ID   A0A287D0Q8_ICTTR        Unreviewed;      2748 AA.
AC   A0A287D0Q8;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   05-DEC-2018, entry version 9.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 1 {ECO:0000313|Ensembl:ENSSTOP00000027166};
GN   Name=ITPR1 {ECO:0000313|Ensembl:ENSSTOP00000027166};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)
OS   (Spermophilus tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha;
OC   Sciuridae; Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000027166, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Ensembl:ENSSTOP00000027166, ECO:0000313|Proteomes:UP000005215}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000027166}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2017) to UniProtKB.
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DR   EMBL; AGTP01065388; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01065389; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01065390; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01065391; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01065392; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSSTOT00000037012; ENSSTOP00000027166; ENSSTOG00000012015.
DR   GeneTree; ENSGT00940000155071; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0005955; C:calcineurin complex; IEA:Ensembl.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005637; C:nuclear inner membrane; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0031088; C:platelet dense granule membrane; IEA:Ensembl.
DR   GO; GO:0031094; C:platelet dense tubular network; IEA:Ensembl.
DR   GO; GO:0014069; C:postsynaptic density; IEA:Ensembl.
DR   GO; GO:0016529; C:sarcoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0098685; C:Schaffer collateral - CA1 synapse; IEA:Ensembl.
DR   GO; GO:0019855; F:calcium channel inhibitor activity; IEA:Ensembl.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0098695; F:inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels; IEA:Ensembl.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:Ensembl.
DR   GO; GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IEA:Ensembl.
DR   GO; GO:0042045; P:epithelial fluid transport; IEA:Ensembl.
DR   GO; GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IEA:Ensembl.
DR   GO; GO:0050849; P:negative regulation of calcium-mediated signaling; IEA:Ensembl.
DR   GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0050882; P:voluntary musculoskeletal movement; IEA:Ensembl.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005215};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2273   2295       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2307   2325       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2394   2419       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2439   2461       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2569   2592       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      112    166       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      173    223       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      231    287       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      294    373       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      379    435       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     1592   1612       {ECO:0000256|SAM:Coils}.
FT   COILED     2686   2727       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2748 AA;  313163 MW;  61C6EBDFF696C6E3 CRC64;
     MSDKMASFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PEAGDLNNPP KKFRDCLFKL
     CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK KQNETENRKL LGTVIQYGNV
     IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD
     KVVLNPVNAG QPLHASSHQL VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV
     RLFHAEQEKF LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN
     SLFRFKHLAT GHYLAAEVDP DFEEECLEFQ PSVDPDQDAS RSRLRNAQEK MVYSLVSVPE
     GNDISSIFEL DPTTLRGGDS LVPRNSYVRL RHLCTNTWVH STNIPIDKEE EKPVMLKIGT
     SPVKEDKEAF AIVPVSPAEV RDLDFANDAS KVLGSIAGKL EKGTITQNER RSVTKLLEDL
     VYFVTGGTNS GQDVLEVVFS KPNRERQKLM REQNILKQIF KLLQAPFTDC GDGPMLRLEE
     LGDQRHAPFR HICRLCYRVL RHSQQDYRKN QEYIAKQFGF MQKQIGYDVL AEDTITALLH
     NNRKLLEKHI TAAEIDTFVS LVRKNREPRF LDYLSDLCVS MNKSIPVTQE LICKAVLNPT
     NADILIETKL VLSRFEFEGV STGENALEAG EDEEEVWLFW RDSNKEIRSK SVRELAQDAK
     EGQKEDRDVL SYYRYQLNLF ARMCLDRQYL AINEISGQLD VDLILRCMSD ENLPYDLRAS
     FCRLMLHMHV DRDPQEQVTP VKYARLWSEI PSEIAIDDYD SSGASRDEIK ERFAQTMEFV
     EEYLRDVVCQ RFPFSDKEKN KLTFEVVNLA RNLIYFGFYN FSDLLRLTKI LLAILDCVHV
     TTIFPISKMA KGEENKGSNV MRSIHGVGEL MTQVVLRGGG FLPMTPMTAA PEGNVKQAEP
     EKEDIMVMDT KLKIIEILQF ILNVRLDYRI SCLLCIFKRE FDESNSQTSE TSSGNSSQEG
     PSNVPGALDF EHIEEQAEGI FGGSEENTPL DLDDHGGRTF LRVLLHLTMH DYPPLVSGAL
     QLLFRHFSQR QEVLQAFKQV QLLVTSQDVD NYKQIKQDLD QLRSIVEKSE LWVYKGQGPD
     ETMDGVSGEN EHKKTEEGNK SEKQESTSSY NYRVVKEILI RLSKLCVQES ASVKKSRKQQ
     QRLLRNMGAH AVVLELLQIP YEKAEDTKMQ EIMRLAHEFL QNFCAGNQQN QALLHKHINL
     FLNPGILEAV TMQHIFMNNF QLCSEINERV VQHFVHCIET HGRNVQYIKF LQTIVKAEGK
     FIKKCQDMVM AELVNSGEDV LVFYNDRASF QTLIQMMRSE RDRMDENSPL MYHIHLVELL
     AVCTEGKNVY TEIKCNSLLP LDDIVRVVTH EDCIPEVKIA YINFLNHCYV DTEVEMKEIY
     TSNHMWKLFE NFLVDICRAC NNTSDRKHAD SILEKYVTEI VMSIVTTFFS SPFSDQSTTL
     QTRQPVFVQL LQGVFRVYHC NWLMPSQKAS VESCIRVLSD VAKSRAIAIP VDLDSQVNNL
     FLKSHNIVQK TAMNWRLSAR NAARRDSVLA ASRDYRNIIE RLQDIVSALE DRLRPLVQAE
     LSVLVDVLHR PELLFPENTD ARRKCESGGF ICKLIKHTKQ LLEENEEKLC IKVLQTLREM
     MTKDRGYGEK QISIDELDNA ELPQAPESEN ATEQELESSP PLRQLEDHKR GEALRQILVN
     RYYGNIRPSG RRESLTSFGN GPLSPGGPSK PGGGGGGSGS NSMSRGEMSL AEVQCHLDKE
     GASNLVIDLI MNASSDRVFH ESILLAIALL EGGNTTIQHS FFCRLTEDKK SERFFKVFYD
     RMKMAQQEIK ATVTVNTSDL GNKKKDDEAD REAPSRKKAK EPTTQITEEV RDQLLEASAA
     TRKAFTTFRR EADPDDHYQS GEGTQTTTDK TKDELEMSAV ITIMQPILRF LQLLCENHNR
     DLQNFLRCQN NKTNYNLVCE TLQFLDCICG STTGGLGLLG LYINEKNVAL INQTLESLTE
     YCQGPCHENQ NCIATHESNG IDIITALILN DINPLGKKRM DLVLELKNNA SKLLLAIMES
     RHDSENAERI LYNMRPKELV EVIKKAYMQG EVEFEDGENG EDGAASPRNV GHNIYILAHQ
     LARHNKELQT MLKPGGQVDG DEALEFYAKH TAQIEIVRLD RTMEQIVFPV PSICEFLTKE
     SKLRIYYTTE RDEQGSKIND FFLRSEDLFN EMNWQKKLRA QPVLYWCARN MSFWSSISFN
     LAVLMNLLVA FFYPFKGVRG GTLEPHWSGL LWTAMLISLA IVIALPKPHG IRALIASTIL
     RLIFSVGLQP TLFLLGAFNV CNKIIFLMSF VGNCGTFTRG YRAMVLDVEF LYHLLYLLIC
     AMGLFVHEFF YSLLLFDLVY REETLLNVIK SVTRNGRSII LTAVLALILV YLFSIVGYLF
     FKDDFILEVD RLPNETAVPE TGESLAGEFL YSDVCRVETG ENCSSPGPKQ ELVPVEETEQ
     DKEHTCETLL MCIVTVLSHG LRSGGGVGDV LRKPSKEEPL FAARVIYDLL FFFMVIIIVL
     NLIFGVIIDT FADLRSEKQK KEEILKTTCF ICGLERDKFD NKTVTFEEHI KEEHNMWHYL
     CFIVLVKVKD STEYTGPESY VAEMIKERNL DWFPRMRAMS LVSSDSEGEQ NELRNLQEKL
     ESTMKLVTNL SGQLSELKDQ MTEQRKQKQR IGLLGHPPHM NVNPQQPA
//
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