ID A0A287D145_ICTTR Unreviewed; 1049 AA.
AC A0A287D145;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=HECT and RLD domain containing E3 ubiquitin protein ligase 4 {ECO:0000313|Ensembl:ENSSTOP00000027242.1};
GN Name=HERC4 {ECO:0000313|Ensembl:ENSSTOP00000027242.1};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000027242.1, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000027242.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGTP01042627; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01042628; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01042629; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01042630; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_013214348.1; XM_013358894.1.
DR AlphaFoldDB; A0A287D145; -.
DR Ensembl; ENSSTOT00000038076.1; ENSSTOP00000027242.1; ENSSTOG00000020342.2.
DR GeneID; 101963907; -.
DR CTD; 26091; -.
DR GeneTree; ENSGT00940000158924; -.
DR OrthoDB; 5475808at2759; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 2.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR PANTHER; PTHR45622:SF5; E3 UBIQUITIN-PROTEIN LIGASE HERC4-RELATED; 1.
DR PANTHER; PTHR45622; UBIQUITIN-PROTEIN LIGASE E3A-RELATED; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF00415; RCC1; 7.
DR PRINTS; PR00633; RCCNDNSATION.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS00626; RCC1_2; 3.
DR PROSITE; PS50012; RCC1_3; 7.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT REPEAT 1..52
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 53..102
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 103..155
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 156..208
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 209..260
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 261..312
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 314..380
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 722..1049
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT ACT_SITE 1017
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 1049 AA; 117727 MW; CB7F18D5B3A17D0E CRC64;
MLCWGNASFG QLGLGGIDEE IVLEPRKSDF FVNKKVRDVG CGLRHTVFVL DDGTVYTCGC
NDLGQLGHEK SRKKPEQVVA LDAQNIVAVS CGEAHTLALN DKGQVYAWGL DSDGQLGLLG
SEECIRVPRN IKSLSDIQIV QVACGYYHSL ALSKASEVFC WGQNKYGQLG LGIECKRQAS
PQLIKSLLGI PFMQVAAGGA HSFVLTLSGA IFGWGRNKFG QLGLNDENDR YVPNLLKSLR
SQKIVYICCG EDHTAALTKE GGVFTFGAGG YGQLGHNSTS HEINPRKVFE LMGSIVTQIA
CGRQHTSAFV PSSGRIYSFG LGGNGQLGTG STSNRKSPFT VKGNWFPYNG QCSLDSDSEE
YFCVKRIFSG GDQSFSHYSS PQTCGPPDDF RCPDPSKQIW TVNEALIQKW LSYPSGRFPV
EIANEIDGTF SSSGCLNGSF LAVSNDDHYR TGTRFPGVDM NAARLLFHKL IQPDHPQISQ
QVAASLEKNL IPKLTSSLPD VEALRFYLTL PECPLMSDSN NFTTIAIPFG TALVNLEKAP
LKVLENWWSI LEPPLFFKIV ELFKEVVVHL LKLYKIGIPP SERRIFNSFL HTALKVLEIL
HRVNEKAGQI IQYDKFYIHE VQELIDIRND YINWVQQQAY GMLADIPVTI CTYPFVFDAQ
AKTTLLQTDA VLQMQMAIDQ AHRQNVSSLF LPVIESVNPC LILVVRRENI VGDAMEVLRK
TKNIDYKKPL KVIFVGEDAV DAGGVRKEFF LLIMRELLDP KYGMFRYYED SRLIWFSDKT
FEDSDLFHLI GVICGLAIYN FTIVDLHFPL ALYKKLLKKK PSLDDLKELM PDVGRSMQQL
LDYPEDDIEE TFCLNFTITV ENFGATEVKE LVLNGADTAV NKQNRQEFVD AYVDYIFNKS
VASLFDAFHA GFHKVCGGKV LLLFQPNELQ SMVIGNTNYD WKELEKNTEY KGEYWAEHPT
IKIFWEVFHE LPLEKKKQFL LFLTGSDRIP ILGMKSLKLV IQSTGGGEEY LPVSHTCFNL
LDLPKYSEKE TLRRKLIQAI DHNEGFSLI
//
