ID A0A287D198_ICTTR Unreviewed; 1228 AA.
AC A0A287D198;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=AF4/FMR2 family member 1 {ECO:0000313|Ensembl:ENSSTOP00000027299.1};
GN Name=AFF1 {ECO:0000313|Ensembl:ENSSTOP00000027299.1};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000027299.1, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000027299.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the AF4 family. {ECO:0000256|ARBA:ARBA00007354}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AGTP01117350; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01117351; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01117352; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01117353; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01117354; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005341990.1; XM_005341933.2.
DR AlphaFoldDB; A0A287D198; -.
DR STRING; 43179.ENSSTOP00000027299; -.
DR Ensembl; ENSSTOT00000040247.1; ENSSTOP00000027299.1; ENSSTOG00000006530.3.
DR GeneID; 101960937; -.
DR CTD; 4299; -.
DR GeneTree; ENSGT00950000182974; -.
DR InParanoid; A0A287D198; -.
DR OrthoDB; 4254515at2759; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0008023; C:transcription elongation factor complex; IEA:Ensembl.
DR GO; GO:0010468; P:regulation of gene expression; IEA:InterPro.
DR Gene3D; 6.10.250.2670; -; 1.
DR InterPro; IPR007797; AF4/FMR2.
DR InterPro; IPR043640; AF4/FMR2_CHD.
DR InterPro; IPR043639; AF4_int.
DR PANTHER; PTHR10528; AF4/FMR2 FAMILY MEMBER; 1.
DR PANTHER; PTHR10528:SF6; AF4_FMR2 FAMILY MEMBER 1; 1.
DR Pfam; PF05110; AF-4; 1.
DR Pfam; PF18875; AF4_int; 1.
DR Pfam; PF18876; AFF4_CHD; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT DOMAIN 966..1227
FT /note="AF4/FMR2 C-terminal homology"
FT /evidence="ECO:0000259|Pfam:PF18876"
FT REGION 112..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 213..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 279..346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..774
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 786..974
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1109..1147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..190
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..250
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 326..346
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 386..440
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..500
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 599..613
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 796..847
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 881..895
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1127..1147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1228 AA; 133682 MW; 99C1A8B811ACCAFF CRC64;
MAFTDRVQSS GSSLYNEDRN LLRIREKERR NQEAHQEKET FPEKIPLFGE PYKTAKGDEL
SSRIQNMLGN YEEVKEFLST KSHPQCLDAS ENRLGKPRYS LFPDKGSSIP SNSFHTSIHH
QPIYTPASGP LPVGNISHNP KIAQPRMEPL PSFHAKNYGP PDSQHLIQDR LGQEGYSSSH
HKKGDRRADG DHCALTIDSA PVRELSPLIS SLPSPVPPLS PIHSNQQTLP RMQGSSKVHS
SSNNNKGHCP TKSPKDLAVK VHDNETLQDS LVAVVSHGVA PPQPPSQTFP PPSLPSKSVA
MQQKPTAYVR PMDGQDQAPS ESPELKPLPE EYRQQNFERT DSKVPAEAKL TKLKMPSQTA
EQTYSNEVHC VEEILKEMTH SWPPPLTAIH TPSTAEPSKF PFPTKDSQHI SSATQNQKQY
DAPSKTHPNS QQGTSMLEDD LQLSDSEDSD NEQTPEKPPS SSAPPSAPQS LPEPVASAHS
SSAESESTSD SDSSSDSESE SSSSDSEENE PLETPAPEPE PPTTNKWQLD NWLTKVSQPV
VPAEALGNTE LPRRRQESKG GSESTANQEH SESKDPPPKS SSKVPRVPSE GPHPGKRTCQ
KSPAQQEPPP RQTVGTKQPK KPVKASAQAD SRASLQVESE PGLLPYGSKD QTSKDKPKVK
TKGRPRAGGS REPKPAVPVP SEKKKHKSSP APPSKALSGP EPTKDTVGDR SPEHFALVPL
TQSQGPPHSG GGGRTSGCRQ AVVVQEDSRK DRLPLPLRDT KLLSPLRDTP TPQSLMVKIT
LDLLTRIPQP PGRGSCPKKP EDKQLPVGKK QDSEKRSSDN SSKLAKKRKI ETERDYDNKK
IRLEKEAKSQ SSSSSSSHKE SSKTKTPRPS SEPTKKEMLP PPPVSSSSSS SQKPAKPAHK
RSRQEADICG HDPPKSASST KSNHKDPSVS KHRKVQGKGS GSSAEHKGSS GDAANPFPVP
FLPNGNSKPG KPQVKFDKQQ ADFHMREAKK LKCKAESMTD KVGKAFKYLE AILSFIECGI
AMESESPASK SAYSVYSETV DLIKFTMSLK SFSDATAPTQ EKIFAVLCMR CQSLLNMAMF
RCKKDVAIKY SRTLNEHFKS SSKVAQAPSP CIARSTGTPS PLSPMPSPAS SAGSQSSAGS
MGSSGKTATI STPVTIQNMT SSYVTITSHV LTAFDLWEQA EVLARKNKEF FAQLSTKVCT
LALNSSLVDL VHYIRQGFQR LKQVTKTP
//
