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Database: UniProt
Entry: A0A287D2U2_ICTTR
LinkDB: A0A287D2U2_ICTTR
Original site: A0A287D2U2_ICTTR 
ID   A0A287D2U2_ICTTR        Unreviewed;      4859 AA.
AC   A0A287D2U2;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   05-DEC-2018, entry version 6.
DE   SubName: Full=Ryanodine receptor 1 {ECO:0000313|Ensembl:ENSSTOP00000027873};
GN   Name=RYR1 {ECO:0000313|Ensembl:ENSSTOP00000027873};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)
OS   (Spermophilus tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha;
OC   Sciuridae; Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000027873, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Ensembl:ENSSTOP00000027873, ECO:0000313|Proteomes:UP000005215}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000027873}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2017) to UniProtKB.
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DR   EMBL; AGTP01108623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01108624; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01108625; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01108626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01108627; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01108628; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01108629; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01108630; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01108631; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSSTOT00000033469; ENSSTOP00000027873; ENSSTOG00000024707.
DR   GeneTree; ENSGT00940000155288; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR033215; RyR1.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   PANTHER; PTHR13715:SF15; PTHR13715:SF15; 2.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005215};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4470   4493       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4659   4681       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4740   4763       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       88    143       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      150    195       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      201    255       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      261    318       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      326    383       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      572    788       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1004   1199       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1348   1561       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED     1860   1916       {ECO:0000256|SAM:Coils}.
FT   COILED     2055   2075       {ECO:0000256|SAM:Coils}.
FT   COILED     2888   2908       {ECO:0000256|SAM:Coils}.
FT   COILED     3346   3366       {ECO:0000256|SAM:Coils}.
FT   COILED     3646   3666       {ECO:0000256|SAM:Coils}.
FT   COILED     3716   3736       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4859 AA;  547603 MW;  7FD201E3FC970EEB CRC64;
     LRCVPQDDEV VLQCSATVLK EQLKLCLAAE GFGNRLCFLE PTSNAQNVPP DLAICCFILE
     QSLSVRALQE MLANTVEAGV ESSQGGGHRT LLYGHAILLR HAHSRMYLSC LTTSRSMTDK
     LAFDVGLQED ATGEACWWTM HPASKQRSEG EKVRVGDDLI LVSVSSERYL HLSTASGELQ
     VDASFMQTLW NMNPICSCCE EGYVTGGHVL RLFHGHMDEC LTISPADSDD QRRLVYYEGG
     SVCTHARSLW RLEPLRISWS GSHLRWGQPL RIRHVTTGRY LALTEDQGLV VVDASKAHTK
     ATSFCFRISK EKLDVAPKRD VEGMGPPEIK YGESLCFVQH VASGLWLTYA APDPKALRLG
     VLKKKAMLHQ EGHMDDALSL TRCQQEESQA ARMIHSTAGL YNQFIKGLDS FSGKPRGSGP
     PAGSALPIEG VILSLQDLIG YFEPPSEELQ HEEKQSKLRS LRNRQSLFQE EGMLSLVLNC
     IDRLNVYTTA AHFAEYAGEE AAESWKEIVN LLYELLASLI RGNRTNCALF STNLDWLVSK
     LDRLEASSGI LEVLYCVLIE SPEVLNIIQE NHIKSIISLL DKHGRNHKVL DVLCSLCVCN
     GVAVRSNQDL ITENLLPGRE LLLQTNLINY VTSIRPNIFV GRAEGSTQYG KWYFEVMVDE
     VAPFLTAQAT HLRVGWALTE GYSPYPGGGE GWGGNGVGDD LYSYGFDGLH LWTGHVARPV
     SSPGQHLLAP EDVVSCCLDL SVPSISFRIN GCPVQGVFEA FNLDGLFFPV VSFSAGVKVR
     FLLGGRHGEF KFLPPPGYAP CHEAVLPRER LHLEPIKEYR REGPRGPHLV GPSRCLSHTD
     FVPCPVDTVQ IVLPPHLERI REKLAENIHE LWALTRIEQG WTYGPVRDDN KRLHPCLVDF
     HSLPEPERNY NLQMSGETLK TLLALGCHVG MADEKAEDNL KKTKLPKTYM MSNGYKPAPL
     DLSHVRLTPA QTTLVDRLAE NGHNVWARDR VAQGWSYSAV QDIPARRNPR LVPYRLLDEA
     TKRSNRDSLC QAVRTLLGYG YNIEPPDQEP SQVESQSRWD RVRIFRAEKS YAVQSGRWYF
     EFEAVTTGEM RVGWARPELR PDVELGADDL AYVFNGHRGQ RWHLGSEPFG HPWQSGDVVG
     CMIDLTENTI IFTLNGKVLM SDSGSETAFR EIEIGEGFLP VCSLGPGQVG HLNLGQDVSS
     LRFFAICGLQ EGFEPFAINM QRPVTTWFSK SLPQFEPVPL EHPHYEVARM DGTVDTPPCL
     RLTHRTWGSQ NSLVEMLFLR LSLPVQFYQH FRCTAGATPL APPGLQPPAE DEARAAEPDP
     DYENLRRSAG RWGEAEGGKE GSTKEGTPGG TSQPGGEAQP ARAENEKDAT TEKNKKRGFL
     FKAKKAAMMT QPPATPPLPR LPRDVVPADD RDDPEIILNT TTYYYSVRVF AGQEPSCVWV
     GWVTPDYHQH DMNFDLSKVR AVTVTMGDEQ GNVHSSLKCS NCYMVWGGDF VSPGQQGRIS
     HTDLVIGCLV DLATGLMTFT ANGKESNTFF QVEPNTKLFP AVFVLPTHQN VVQFELGKQK
     NIMPLSAAMF LSERKNPAPQ CPPRLEVQML MPVSWSRMPN HFLQVEMRRA GERLGWAVQC
     QEPLTMMALH IPEENRCMDI LELSERLDLQ RFHSHTLSLY RAVCALGNNR VAHALCSHVD
     QAQLLHALED AHLPGPLRAG YYDLLISIHL ESACRSRRSM LSEYIVPLTP ETRAITLFPP
     GRSAEDGPRR HGLPGVGVTT SLRPPHHFSP PCFVAALPAA GVTEAPARLS PAIPLEALRD
     KALRMLGEAV RDGGQHARDP VGGSVEFQFV PVLKLVSTLL VMGVFSDEDV KQILKMIEPE
     VFTEEEEEEE EEEEEEEEED EEEKEEDEEE EAQEKEDEEK EEEEAAEGEK EEDLEEGLLQ
     MKLPESVKLQ MCHLLEYFCD QELQHRVESL AAFAERYVDK LQANQRDRYG HLMKAFTMTA
     AETARRTREF RSPPQEQINM LLQFKDGADE EDCPLPEEIR QDLLDFHQDL LAHCGIQLEG
     EEEEPEEETT LGSRLMSLLE KVRLVKKKEE KSEEEPQEEH KPRSLQELVS HMVVRWAQED
     FVQSPELVRA MFSLLHRQYD GLGELLRALP RAYTISPSSV EDTMSLLECL GQIRSLLIVQ
     MGPQEENLMI QSIGNIMNNK VFYQHPNLMR ALGMHETVME VMVNVLGGGE SKEIRFPKMV
     TSCCRFLCYF CRISRQNQRS MFDHLSYLLE NSGIGLGMQG STPLDVAAAS VIDNNELALA
     LQEQDLEKVV SYLAGCGLQS CPMLLAKGYP DIGWNPCGGE RYLDFLRFAV FVNGESVEEN
     ANVVVRLLIR KPECFGPALR GEGGSGLLAA IEEAIRISED PARDGPGVRR DRRREHFGEE
     PPEENRVHLG HAIMSFYAAL IDLLGRCAPE MHLIQAGKGE ALRIRAILRS LVPLDDLVGI
     ISLPLQIPTL GKDGALVQPK MSASFVPDHK ASMVLFLDRV YGIENQDFLL HVLDVGFLPD
     MRAAASLDTA TFSTTEMALA LNRYLCLAVL PLITKCAPLF AGTEHRAIMV DSMLHTIYRL
     SRGRSLTKAQ RDVIEDCLMA LCRWGAARGW VGPQAARLLT NHYERCWKYY CLPTGWANFG
     VTSEEELHLT RKLFWGIFDS LAHKKYDQEL YRMAMPCLCA IAGALPPDYV DASYSSKAEK
     KATVDAEGNF DPRPVETLNV IIPEKLDSFI NKFAEYTHEK WAFDKIQNNW SYGENVDEEL
     KTHPMLRPYK TFSEKDKEIY RWPIKESLKA MIAWEWTIEK AREGEEEKTE KKKTRKISQT
     AQTYDPREGY NPQPPDLSGV TLSRELQAMA EQLAENYHNT WGRKKKQELE AKGGGSHPLL
     VPYDTLTAKE KARDREKAQE LLKFLQMNGY AVTRGLKDME LDTSSIEKRF AFGFLQQLLR
     WMDISQEFIA HLEAVVSSGR VEKSPHEQEI KFFAKILLPL INQYFNNHCL YFLSTPAKVL
     GSGGHASNKE KEMITSLFCK LAALVRHRVS LFGTDAPAVV NCLHILARSL DARTVMKSGP
     EIVKAGLRSF FESASEDIEK MVENLRLGKV SQARTQVKGV GQNLTYTTVA LLPVLTTLFQ
     HIAQHQFGDD VILDDVQVSC YRTLCSIYSL GTTRNPYVEK LRPALGECLA RLAAAMPVAF
     LEPQLNEYNA CSVYTTKSPR ERAILGLPNS VEEMCPDIPV LERLMAEIGG LAESGARYTE
     MPHVIEVTLP MLCSYLPRWW ERGPEAPPPA LPAGAPPPCT AVTSDHLNSL LGNILRIIVN
     NLGIDEASWM KRLAVFAQPI VSRARPELLR SHFIPTIGRL RKRAGKVVAE EEQLRLEAKA
     EAEEGELLVR DEFSVLCRDL YALYPLLIRY VDNNRAHWLT EPNPNAEELF RMVGEIFIYW
     SKSHNFKREE QNFVVQNEIN NMSFLTADNK SKMAKVRSGG SDQERTKKKR RGDRYSVQTS
     LIVATLKKML PIGLNMCAPT DQDLMVLAKA RYALKDTDEE VREFLQNNLN LQGKVEGSPS
     LRWQMALYRG LPGREEEADD PEKIVRRVQE VSAVLYHLDQ IEHPYKSKKA VWHKLLSKQR
     RRAVVACFRM TPLYNLPTHR ACNMFLESYK AAWILTEDHS FEDRMIDDLS RAGEQEEEEE
     EVEEKKPDPL HQLVLHFSRT ALTEKSKLDE DYLYMAYADI MAKSCHLEEG GESGEAEEEE
     AEVSFEEKEM EKQRLLYQQS RLHNRGAAEM VLQMISACKG ETGAMVSSTL KLGISILNGG
     NADVQQKMLD YLKDKKDVGF FQSIQALMQT CSVLDLNAFE RQNKAEGLGM VNEDGTVINR
     QNGNSPKVMA DDEFTQDLFR FLQLLCEGHN NDFQNYLRTQ TGNTNTINII ICTVDYLLRL
     QESISDFYWY YSGKDVIEEQ GKRNFSKAMS VAKQVFNSLT EYIQGPCTGN QQSLAHSRLW
     DAVVGFLHVF AHMMMKLAQD SSQIALLKEL LDLQKDMVVM LLSLLEGNVV NGMIARQMVD
     MLVESSSNVE MILKFFDMFL KLKDIVGSEA FQDYVTDPRG LISKKDFQKA MDSQKQFSGP
     EIQFLLSCSE ADENEMINCD EFANRFQEPA RDIGFNVAVL LTNLSEHVPH DPRLRTFLEL
     AESILDYFRP YLGRIEIMGA SRRIERIYFE ISETNRAQWE MPQVKESKRQ FIFDVVNEGG
     EAEKMELFVS FCEDTIFEMQ IAAQISEPEG EPEEDEDEGG EAAEEAGPGG VDGAVAVADG
     SPFRPEGVGG LGDMGDTTPA EPPTPEGSPI LKRKLGVDGE EEELPPEPEP EPEPEKAEPE
     GAFTENGEKE EVPEPPPEPP KKTAPPPPPP KKEEAGSAGM EFWAELEVQR VKFLNYLSRN
     FYTLRFLALF LAFAINFILL FYKVSDSPPG EDDVEGSAAG DLMGAGSGGG SGWGSGAGEE
     AEDDEDENMV YYFLEESTGY MAPALRCLSL LHTLVAFLCI IGYNCLKVPL VIFKREKELA
     RKLEFDGLYI TEQPEDDDVK GQWDRLVLNT PSFPSNYWDK FVKRKVLDKH GDIFGRERIA
     ELLGMDLASL EITAHSERKP DPPPGLLTWL MSIDVKYQIW KFGVIFTDNS FLYLSWYMVM
     SLLGHYNNFF FAAHLLDIAM GVKTLRTILS SVTHNGKQLV MTVGLLAVVV YLYTVVAFNF
     FRKFYNKSED EDEPDMKCDD MMTCYLFHMY VGVRAGGGIG DEIEDPAGDE YELYRVVFDI
     TFFFFVIIIL LAIIQGLIID AFGELRDQQE QVKEDMETKC FICGIGSDYF DTTPHGFETH
     TLEEHNLANY MFFLMYLINK DETEHTGQES YVWKMYQERC WDFFPAGDCF RKQYEDQLS
//
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