ID A0A287D3P6_ICTTR Unreviewed; 329 AA.
AC A0A287D3P6;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=DNA repair protein {ECO:0000256|PIRNR:PIRNR005856};
GN Name=RAD51D {ECO:0000313|Ensembl:ENSSTOP00000028178.1};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000028178.1, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000028178.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in the homologous recombination repair (HRR) pathway
CC of double-stranded DNA breaks arising during DNA replication or induced
CC by DNA-damaging agents. {ECO:0000256|PIRNR:PIRNR005856}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR005856}.
CC -!- SIMILARITY: Belongs to the RecA family. RAD51 subfamily.
CC {ECO:0000256|PIRNR:PIRNR005856}.
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DR EMBL; AGTP01050539; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005327816.1; XM_005327759.2.
DR AlphaFoldDB; A0A287D3P6; -.
DR STRING; 43179.ENSSTOP00000028178; -.
DR Ensembl; ENSSTOT00000035084.1; ENSSTOP00000028178.1; ENSSTOG00000006142.3.
DR GeneID; 101969774; -.
DR CTD; 5892; -.
DR GeneTree; ENSGT00940000159095; -.
DR InParanoid; A0A287D3P6; -.
DR OMA; QRIHTFR; -.
DR OrthoDB; 11612at2759; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:Ensembl.
DR GO; GO:0033063; C:Rad51B-Rad51C-Rad51D-XRCC2 complex; IEA:Ensembl.
DR GO; GO:0005657; C:replication fork; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:Ensembl.
DR GO; GO:0000400; F:four-way junction DNA binding; IEA:Ensembl.
DR GO; GO:0043015; F:gamma-tubulin binding; IEA:Ensembl.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0042148; P:DNA strand invasion; IEA:Ensembl.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:Ensembl.
DR GO; GO:0036297; P:interstrand cross-link repair; IEA:Ensembl.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:Ensembl.
DR GO; GO:0000722; P:telomere maintenance via recombination; IEA:Ensembl.
DR CDD; cd19489; Rad51D; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013632; DNA_recomb/repair_Rad51_C.
DR InterPro; IPR016467; DNA_recomb/repair_RecA-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047323; Rad51D_C.
DR InterPro; IPR048943; RAD51D_N.
DR InterPro; IPR020588; RecA_ATP-bd.
DR PANTHER; PTHR46457; DNA REPAIR PROTEIN RAD51 HOMOLOG 4; 1.
DR PANTHER; PTHR46457:SF1; DNA REPAIR PROTEIN RAD51 HOMOLOG 4; 1.
DR Pfam; PF08423; Rad51; 1.
DR Pfam; PF21794; RAD51D_N; 1.
DR PIRSF; PIRSF005856; Rad51; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50162; RECA_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00023204};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR005856};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT DOMAIN 78..251
FT /note="RecA family profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50162"
SQ SEQUENCE 329 AA; 35405 MW; 523AA62CC3D40C09 CRC64;
MGVLRAGLCP GLTQEMVQLL KSRGIKTVVD LAAADLEEVA QKCSLSYKAL VALRRVLLAQ
FSAFPSNGAD LYEEMKTSTA ILSTGIGSLD KLLDAGLYTG EVTEIVGGPG SGKTQVCLCV
AANVAHGLQQ NVLYIDSNGG LTASRLLQLL QPRTQDEEEQ ARALQRIQVV RAFDIFQMLD
VLQDLRGTVT QQVRCSSGTV KVVIVDSVTA VVSPLLGGQQ RDGLALMMQL ARELKTLARE
LSMAVVVTNH MTRDRDSGKF KPALGRSWSF VPSTRILLDI IEGTGASGSS QRTVSLTKSP
RQPTGFQEVV DIGTWETPEQ SPVFQGEQT
//
