ID A0A287D5G8_ICTTR Unreviewed; 244 AA.
AC A0A287D5G8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Myelin-oligodendrocyte glycoprotein {ECO:0000256|ARBA:ARBA00019547, ECO:0000256|PIRNR:PIRNR016522};
GN Name=MOG {ECO:0000313|Ensembl:ENSSTOP00000028755.1};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000028755.1, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000028755.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Minor component of the myelin sheath. May be involved in
CC completion and/or maintenance of the myelin sheath and in cell-cell
CC communication. Mediates homophilic cell-cell adhesion.
CC {ECO:0000256|PIRNR:PIRNR016522}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|PIRNR:PIRNR016522}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. BTN/MOG family.
CC {ECO:0000256|PIRNR:PIRNR016522}.
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DR EMBL; AGTP01099519; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005338877.1; XM_005338820.2.
DR AlphaFoldDB; A0A287D5G8; -.
DR STRING; 43179.ENSSTOP00000028755; -.
DR Ensembl; ENSSTOT00000033963.1; ENSSTOP00000028755.1; ENSSTOG00000002496.3.
DR GeneID; 101970123; -.
DR CTD; 4340; -.
DR eggNOG; ENOG502SQC1; Eukaryota.
DR GeneTree; ENSGT00940000153527; -.
DR InParanoid; A0A287D5G8; -.
DR OrthoDB; 2943983at2759; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-UniRule.
DR CDD; cd05713; IgV_MOG_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR016663; Myelin-oligodendrocyte_glycop.
DR PANTHER; PTHR24100; BUTYROPHILIN; 1.
DR PANTHER; PTHR24100:SF71; MYELIN-OLIGODENDROCYTE GLYCOPROTEIN; 1.
DR Pfam; PF07686; V-set; 1.
DR PIRSF; PIRSF016522; MOG; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|PIRNR:PIRNR016522};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|PIRNR:PIRNR016522, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..244
FT /note="Myelin-oligodendrocyte glycoprotein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011437174"
FT TRANSMEM 152..175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 206..228
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 10..142
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 244 AA; 27862 MW; 9A9BA3D60BF38518 CRC64;
MAGLSSFSLP SCVLTLLFLQ LSSSYAGQFR VIGPGHPIRA LVGDEVELPC RLSPGKNATG
MEVGWYRPPF SRVVHLYRNG KDQDAEQAPE YRGRTELLKE TIGEGKVTLR IRNVRFSDEG
GFTCFFRDHS YQEEAAMELK VEDPFYWINP GVLVLIAVLP VLLLQITVGL VFLCLQHRLR
GKLRAEIENL HRTFDRHFLR VPCWKITLFV IVPVLGPLVA LIICYNWLHR RLAGQFLEEL
RNPF
//
