ID A0A287D964_ICTTR Unreviewed; 696 AA.
AC A0A287D964;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=DNA-binding protein SATB {ECO:0000256|RuleBase:RU361129};
DE AltName: Full=Special AT-rich sequence-binding protein {ECO:0000256|RuleBase:RU361129};
GN Name=SATB2 {ECO:0000313|Ensembl:ENSSTOP00000030046.1};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000030046.1, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000030046.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the CUT homeobox family.
CC {ECO:0000256|ARBA:ARBA00008190, ECO:0000256|RuleBase:RU361129}.
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DR EMBL; AGTP01034076; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01034077; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A287D964; -.
DR STRING; 43179.ENSSTOP00000030046; -.
DR Ensembl; ENSSTOT00000042696.1; ENSSTOP00000030046.1; ENSSTOG00000024964.2.
DR eggNOG; KOG3755; Eukaryota.
DR GeneTree; ENSGT00390000008096; -.
DR InParanoid; A0A287D964; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0000118; C:histone deacetylase complex; IEA:Ensembl.
DR GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0051216; P:cartilage development; IEA:Ensembl.
DR GO; GO:0071310; P:cellular response to organic substance; IEA:Ensembl.
DR GO; GO:0006338; P:chromatin remodeling; IEA:Ensembl.
DR GO; GO:0009880; P:embryonic pattern specification; IEA:Ensembl.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0001764; P:neuron migration; IEA:Ensembl.
DR GO; GO:0002076; P:osteoblast development; IEA:Ensembl.
DR GO; GO:0060021; P:roof of mouth development; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR CDD; cd11585; SATB1_N; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 2.
DR Gene3D; 1.10.260.70; SATB, CULT domain; 1.
DR Gene3D; 3.10.20.710; SATB, ubiquitin-like oligomerisation domain; 1.
DR InterPro; IPR003350; CUT_dom.
DR InterPro; IPR032355; CUTL.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR039673; SATB1/SATB2.
DR InterPro; IPR038216; SATB_CUTL_sf.
DR InterPro; IPR038224; SATB_ULD_sf.
DR InterPro; IPR032392; ULD.
DR PANTHER; PTHR15116; DNA-BINDING PROTEIN SATB FAMILY MEMBER; 1.
DR PANTHER; PTHR15116:SF15; DNA-BINDING PROTEIN SATB2; 1.
DR Pfam; PF02376; CUT; 2.
DR Pfam; PF16557; CUTL; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF16534; ULD; 1.
DR SMART; SM01109; CUT; 2.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 2.
DR PROSITE; PS51042; CUT; 2.
DR PROSITE; PS51983; CUTL; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS51982; ULD; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|RuleBase:RU361129};
KW Transcription regulation {ECO:0000256|RuleBase:RU361129};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 20..121
FT /note="ULD"
FT /evidence="ECO:0000259|PROSITE:PS51982"
FT DOMAIN 124..197
FT /note="CUTL"
FT /evidence="ECO:0000259|PROSITE:PS51983"
FT DOMAIN 313..400
FT /note="CUT"
FT /evidence="ECO:0000259|PROSITE:PS51042"
FT DOMAIN 436..523
FT /note="CUT"
FT /evidence="ECO:0000259|PROSITE:PS51042"
FT DOMAIN 575..636
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 577..637
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 398..436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 543..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 656..696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..436
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..557
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 558..573
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 656..675
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 676..696
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 696 AA; 78429 MW; 7A4A03A0DCBFC7D0 CRC64;
GSPMGARGRP NGAVAKAVGG LMIPVFCVVE QLDSSLEYDN REEHAEFVLV RKDVLFSQLV
ETALLALGYS HSSAAQAQGI IKLGRWNPLP LSYVTDAPDA TVADMLQDVY HVVTLKIQLQ
SCSKLEDLPA EQWNHATVRN ALKELLKEMN QSTLAKECPL SQSMISSIVN STYYANVSAT
KCQEFGRWYK KYKKIKVERV ERENLSDYCV LGQRPMHLPN MNQLASLGKT NEQSPHSQIH
HSTPIRNQVP ALQPIMSPGL LSPQLSPQLV RQQIAMAHLI NQQIAVSRLL AHQHPQAINQ
QFLNHPPIPR AVKPEPTNSS VEVSPDIYQQ VRDELKRASV SQAVFARVAF NRTQGLLSEI
LRKEEDPRTA SQSLLVNLRA MQNFLNLPEV ERDRIYQDER ERSMNPNVSM VSSASSSPSS
SRTPQAKTST PTTDLPIKVD GANVNITAAI YDEIQQEMKR AKVSQALFAK VAANKSQGWL
CELLRWKENP SPENRTLWEN LCTIRRFLNL PQHERDVIYE EESRHHHSER MQHVVQLPPE
PVQVLHRQQS QPTKESSPPR EEAPPPPPPT EDSCAKKPRS RTKISLEALG ILQSFIHDVG
LYPDQEAIHT LSAQLDLPKH TIIKFFQNQR YHVKHHGKLK EHLGSAVDVA EYKDEELLTE
SEENDSEEGS EEMYKVEAEE EGAEKSKAAP AEIDQR
//
