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Database: UniProt
Entry: A0A287D982_ICTTR
LinkDB: A0A287D982_ICTTR
Original site: A0A287D982_ICTTR 
ID   A0A287D982_ICTTR        Unreviewed;       426 AA.
AC   A0A287D982;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   18-SEP-2019, entry version 13.
DE   SubName: Full=Potassium voltage-gated channel subfamily J member 6 {ECO:0000313|Ensembl:ENSSTOP00000030115};
GN   Name=KCNJ6 {ECO:0000313|Ensembl:ENSSTOP00000030115};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)
OS   (Spermophilus tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha;
OC   Sciuridae; Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000030115, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Ensembl:ENSSTOP00000030115, ECO:0000313|Proteomes:UP000005215}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000030115}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2017) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   EMBL; AGTP01030160; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01030161; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01030162; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01030163; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01030164; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01030165; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01030166; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01030167; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01030168; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01030169; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005323544.1; XM_005323487.2.
DR   STRING; 43179.ENSSTOP00000014459; -.
DR   Ensembl; ENSSTOT00000041242; ENSSTOP00000030115; ENSSTOG00000016154.
DR   GeneTree; ENSGT00970000193368; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015467; F:G-protein activated inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR003275; K_chnl_inward-rec_Kir3.2.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   PANTHER; PTHR11767:SF19; PTHR11767:SF19; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01328; KIR32CHANNEL.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005215};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     96    120       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    170    194       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       60    199       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      206    375       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION      391    426       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    395    426       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   SITE        185    185       Role in the control of polyamine-mediated
FT                                channel gating and in the blocking by
FT                                intracellular magnesium.
FT                                {ECO:0000256|PIRSR:PIRSR005465-1}.
SQ   SEQUENCE   426 AA;  48818 MW;  DF976419EDABF125 CRC64;
     MTTMAKLTES MTNVLEGDSM DQDVESPVAI HQPKLPKQAR DDLPRHISRD RTKRKIQRYV
     RKDGKCNVHH GNVRETYRYL TDIFTTLVDL KWRFNLLIFV MVYTVTWLFF GMIWWLIAYI
     RGDMDHIEDP SWTPCVTNLN GFVSAFLFSI ETETTIGYGY RVITDKCPEG IILLLIQSVL
     GSIVNAFMVG CMFVKISQPK KRAETLVFST HAVISMRDGK LCLMFRVGDL RNSHIVEASI
     RAKLIKSKQT SEGEFIPLNQ TDINVGYYTG DDRLFLVSPL IISHEINQQS PFWEISKAQL
     PKEELEIVVI LEGMVEATGM TCQARSSYIT SEILWGYRFT PVLTLEDGFY EVDYNSFHET
     YETSTPSLSA KELAELASRA EMPLSWSVSS KLNQHAELET EEEEKNQEEQ TERNGDVANL
     ENESKV
//
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