ID A0A287DAC9_ICTTR Unreviewed; 216 AA.
AC A0A287DAC9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=3',5'-cyclic-AMP phosphodiesterase {ECO:0000256|ARBA:ARBA00012276};
DE EC=3.1.4.53 {ECO:0000256|ARBA:ARBA00012276};
GN Name=PDE4B {ECO:0000313|Ensembl:ENSSTOP00000030522.1};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000030522.1, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000030522.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3',5'-cyclic AMP + H2O = AMP + H(+); Xref=Rhea:RHEA:25277,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58165,
CC ChEBI:CHEBI:456215; EC=3.1.4.53;
CC Evidence={ECO:0000256|ARBA:ARBA00033681};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25278;
CC Evidence={ECO:0000256|ARBA:ARBA00033681};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- PATHWAY: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from
CC 3',5'-cyclic AMP: step 1/1. {ECO:0000256|ARBA:ARBA00004703}.
CC -!- SIMILARITY: Belongs to the cyclic nucleotide phosphodiesterase family.
CC PDE4 subfamily. {ECO:0000256|ARBA:ARBA00009517}.
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DR EMBL; AGTP01069800; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01069801; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01069802; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01069803; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01069804; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01069805; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01069806; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01069807; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01069808; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01069809; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A287DAC9; -.
DR Ensembl; ENSSTOT00000042098.1; ENSSTOP00000030522.1; ENSSTOG00000028938.2.
DR GeneTree; ENSGT00940000155190; -.
DR UniPathway; UPA00762; UER00747.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; IEA:UniProtKB-EC.
DR GO; GO:0006198; P:cAMP catabolic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR040844; PDE4_UCR.
DR PANTHER; PTHR40141:SF3; 3',5'-CYCLIC-AMP PHOSPHODIESTERASE; 1.
DR PANTHER; PTHR40141; 3',5'-CYCLIC-AMP PHOSPHODIESTERASE-RELATED; 1.
DR Pfam; PF18100; PDE4_UCR; 1.
PE 3: Inferred from homology;
KW cAMP {ECO:0000256|ARBA:ARBA00023149};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT DOMAIN 151..197
FT /note="Phosphodiesterase 4 upstream conserved regions
FT (UCR)"
FT /evidence="ECO:0000259|Pfam:PF18100"
FT REGION 32..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 84..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 216 AA; 24132 MW; C49F553230919B22 CRC64;
MTAKNSSKEL TASESEVCIK TFKEQMHLEL ELPRLPGNRP TSPKISPRSS PRNSPCFFRK
LLVNKSIRQR RRFTVAHTCF DVENGPSPGR SPLDPQASSS SGLVLHATFP GHSQRRESFL
YRSDSDYDLS PKAMSRNSSL PSEQHGDDLI VTPFAQVLAS LRSVRNNFTL LTNLHGTSNK
RSPAASQPPV SRVNLQEWDS WGVMTRRTGS RRARTG
//
