ID A0A287DAR4_ICTTR Unreviewed; 1321 AA.
AC A0A287DAR4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 {ECO:0000313|Ensembl:ENSSTOP00000030650.1};
GN Name=RAPH1 {ECO:0000313|Ensembl:ENSSTOP00000030650.1};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000030650.1, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000030650.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGTP01081149; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01081150; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSSTOT00000037740.1; ENSSTOP00000030650.1; ENSSTOG00000028594.2.
DR eggNOG; KOG3751; Eukaryota.
DR GeneTree; ENSGT00940000156552; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01259; PH_APBB1IP; 1.
DR CDD; cd16136; RA_MRL_Lpd; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR039664; GRB/APBB1IP.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039665; PH_APBB1IP.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR11243; GROWTH FACTOR RECEPTOR-BOUND PROTEIN; 1.
DR PANTHER; PTHR11243:SF15; RAS-ASSOCIATED AND PLECKSTRIN HOMOLOGY DOMAINS-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00788; RA; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00314; RA; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50200; RA; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT DOMAIN 321..407
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 448..557
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 104..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 178..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 587..621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 638..805
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 851..1105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1119..1232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1246..1321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..21
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 178..221
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 655..673
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 674..705
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 706..730
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 761..782
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 856..872
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 883..921
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 928..954
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 969..1020
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1083..1097
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1138..1160
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1168..1182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1204..1232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1246..1263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1321 AA; 143394 MW; B85BAFB8A09354AF CRC64;
MEQLSDEEID HGAEEDSDKE DQDLDKMFGA WLGELDKLTQ TLDSDKPIEP VKRSPLRQET
NMANFSYRFS IYNLNEALNQ GETVDLDALM ADLCSIEQEL NSIGSGNSKR QVTETKTTQK
LPANRHTSKH GTLKGLSSSS NRITKPSHAN YSLDDITAQL EQASLSMDEA AQQSLLEDTK
PLVTNQHRRT ASAGTVSDAE VRSISNSSRS SITSAASSMD SLDIDKVTRP QELDLTSQGQ
PITEHAISLR CPRKQAKRHI DFTEEQAELT PHSYLDRETS LLLRNIAGKP SHLLTKEEQA
AKLKAEKIRI ALEKIKEAQV KKLVIRVHMS DDSSKTMMVD ERQTVRQVLD NLMDKSHCGY
SLDWSLVETI SELQMERIFE DHENLVENLL NWTRDSQNKL IFMERIEKYA LFKNPQNYLL
GKKETAEMAD RNKEVLLEEC FCGSSVTVPE IEGVLWLKDD GKKSWKKRYF LLRASGIYYV
PKGKAKVSRD LMCFLQLDHV NVYYGQDYRN KYKAPTDYCL VLKHPQIQKK SQYIKYLCCD
DVRTLHQWVN GIRIAKYGKQ LYMNYQEALK RTESAYDWTS LSSSSIKSGS SSSSIPESQS
NHSNQSDSGV SDTQPAGHVR SQSIVSSIFS EAWKRGTQLE ESSKARMESV NRPYTSLMPP
LSPQTKIVTP YTASQPSPPL PPPPPPPPPP PPPPPPPPPP LPSQSAPSAG SSATMFVKYS
TITRLQNAAQ HSGPLFKPPP PPVMQSLPLA SQSVKPQILV PPSGVVPPPP PPPPPPTPGS
AMAQLKPAPC APSLPQFNPP PPPLKIHQVQ HVTQVAPLTP PPAPPIPAVL PPQAPPKPIV
TIPAPASAKT VPPVMTQAAP PTPAPPIPPA KKQAVFPISH VPPSVSAPIP APTPAPVPPP
TLPKQQSFCA KPPPPPLSPV PSLVKQMVSQ FPPPPTPPPV ESQPLKPIPA NLTPQSPPAV
KAKPKWQPSS IPAPSPDFPP PPPESSLVFP PPPPPPPPPP PPPAPAPAPP PVPPTASPTP
DKGGSPGKKP SKMSSPGGKK PPPTPQRNSS IKSSTCAEHP EPKRPSIDSL VSKFAPPTES
GSPIKETPLP PAAPPKPGKL HLSGVSLPNV LQQGCVSSKP SLLSGRAKDS VVEFPSPPSD
SDFPPPPPEI ELPPPPIEIP AVFSGNTSPK VAVVNPQPQP WSKASVKKAP PPTRPKRNDS
TRLTQAEISE QPTMATVVPQ VPTSPKSSLS VQPGFLADLN RTLQRKSITR HGSLSSSRMS
RAEPTATMDD MALPPPPPEL LSDQQKASYG GSHISGYATL RRGPPPAPPK RDQNTKLSRD
W
//
