ID A0A287DB25_ICTTR Unreviewed; 495 AA.
AC A0A287DB25;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Rho guanine nucleotide exchange factor 9 {ECO:0000256|ARBA:ARBA00017486};
DE AltName: Full=Collybistin {ECO:0000256|ARBA:ARBA00031572};
DE AltName: Full=Rac/Cdc42 guanine nucleotide exchange factor 9 {ECO:0000256|ARBA:ARBA00032237};
GN Name=ARHGEF9 {ECO:0000313|Ensembl:ENSSTOP00000030738.1};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000030738.1, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000030738.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Acts as a guanine nucleotide exchange factor (GEF) for CDC42.
CC Promotes formation of GPHN clusters. {ECO:0000256|ARBA:ARBA00043844}.
CC -!- SUBUNIT: Interacts with GPHN. {ECO:0000256|ARBA:ARBA00011232}.
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DR EMBL; AGTP01082040; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01082041; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_013218275.1; XM_013362821.1.
DR AlphaFoldDB; A0A287DB25; -.
DR Ensembl; ENSSTOT00000042426.1; ENSSTOP00000030738.1; ENSSTOG00000026917.2.
DR GeneID; 101977124; -.
DR CTD; 23229; -.
DR GeneTree; ENSGT00940000154103; -.
DR OrthoDB; 24739at2759; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd01224; PH_Collybistin_ASEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11975; SH3_ARHGEF9; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035728; ARHGEF9_SH3.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR47544; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4; 1.
DR PANTHER; PTHR47544:SF2; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 9; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..46
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 82..266
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 297..404
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 432..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 495 AA; 58650 MW; 8796D760D8C04A84 CRC64;
MANRELAFKA GDVIKVLDAS NKDWWWGQID DEEGWFPASF VRLWVNQEDG VEEGPSDVQN
GHLDPNSDCL CLGRPLQNRD QMRANVINEI MSTERHYIKH LKDICEGYLK QCRKRRDMFS
DEQLKVIFGN IEDIYRFQMG FVRDLEKQYN NDDPHLSEIG PCFLEHQDGF WIYSEYCNNH
LDACMELSKL MKDSRYQHFF EACRLLQQMI DIAIDGFLLT PVQKICKYPL QLAELLKYTA
QDHSDYRYVA AALAVMRNVT QQINERKRRL ENIDKIAQWQ ASVLDWEGED ILDRSSELIY
TGEMAWIYQP YGRNQQRVFF LFDHQMVLCK KDLIRRDILY YKGRIDMDKY EVVDIEDGRD
DDFNVSMKNA FKLQNKEKNE VHLFFAKKLE EKIRWLRAFR EERKMVQEDE KIGFEISENQ
KRQAAMTVRK VPKQKGVNSA RSVPPSYPPP QDPLNQGQYL VPDGIAQSQV FEFTEPKRSQ
SPFWQNFSRL TPFKK
//
