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Database: UniProt
Entry: A0A287DBM1_ICTTR
LinkDB: A0A287DBM1_ICTTR
Original site: A0A287DBM1_ICTTR 
ID   A0A287DBM1_ICTTR        Unreviewed;      4870 AA.
AC   A0A287DBM1;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   05-DEC-2018, entry version 7.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSSTOP00000030938};
GN   Name=RYR3 {ECO:0000313|Ensembl:ENSSTOP00000030938};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)
OS   (Spermophilus tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha;
OC   Sciuridae; Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000030938, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Ensembl:ENSSTOP00000030938, ECO:0000313|Proteomes:UP000005215}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000030938}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2017) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; AGTP01091581; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01091582; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01091583; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01091584; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01091585; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01091586; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01091587; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01091588; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01091589; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01091590; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSSTOT00000040970; ENSSTOP00000030938; ENSSTOG00000007697.
DR   GeneTree; ENSGT00940000155507; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005215};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4183   4207       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4411   4431       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4479   4498       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4610   4628       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4671   4692       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4751   4774       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      100    155       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      162    207       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      215    269       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      275    333       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      343    400       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      585    796       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1012   1208       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1254   1466       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3918   3953       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      459    479       {ECO:0000256|SAM:Coils}.
FT   COILED     3218   3238       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4870 AA;  552197 MW;  DC20C1BC8E5F38BC CRC64;
     MAEGGEGGED EIQFLRTEDE VVLQCIASIH KEQRKFCLAA EGLGNRLCFL EPTSEAKYIP
     PDLCVCNFVL EQSLSVRALQ EMLANTGENG GEGAAQGGGH RTLLYGHAIL LRHSFSGMYL
     TCLTTSRSQT DKLAFDVGLQ EQATGEACWW TIHPASKQRS EGEKVRIGDD LILVSVSSER
     YLHLSISNGN IQVDASFMQT LWNVHPTCSG SSIEEGYLLG GHVVRLFHGH DECLTIPSTD
     QNDSQHRRVF YEAGGAGTRA RSLWRVEPLR ISWSGSNIRW GQAFRLRHLT TGHYLALTED
     QGLLLQDRGK SDTKSTAFSF RASKEIKEKL DSSHKRDMEG MGVPEIKYGD SICFVQHIAS
     GLWVTYKAQD AKTSRLGPLK RKVILHQEGH MDDGLTLQRC QREESQAARI IRNTTALFSQ
     FVSGNNRTAA PVTLPIEEVL QTLQDLIAYF QPPEEEMRHE DKQNKLRSLK NRQNLFKEEG
     MLALVLNCID RLNIYNSVAH FAGIAREESG MAWKEILNLL YKLLAALIRG NRNNCAQFSN
     NLDWLISKLD RLESSSGILE VLHCILIESP EALNLIAEGH IKSIISLLDK HGRNHKVLDV
     LCSLCLCNGV AVRANQNLIC DNLLPRRNLL LQTRLINDVT SIRPNIFLGV AEGSAQYKKW
     YFELIIDQVD PFLTAEPTHL RVGWASSSGY APYPGGGEGW GGNGVGDDLY SYGFDGLHLW
     SGRIPRAVAS INQHLLKSDD VVSCCLDLGV PSISFRINGQ PVQGMFENFN TDGLFFPVMS
     FSAGVKVRFL MGGRHGEFKF LPPSGYAPCY EALLPKEKMR LEPVKEYKRD ADGVRDLLGT
     TQFLSQASFI PCPIDTSQVV LPPHLEKIRD RLAENIHELW GMNKIELGWT FGKIRDDNKR
     QHPCLVEFSK LPETEKNYNL QMSTETLKTL LALGCHIAHV NPAAEDDLKK VKLPKNYMMS
     NGYKPAPLDL SDVKLLPPQE ILVDKLAENA HNVWAKDRIK QGWTYGIQQD LKNKRNPRLV
     PYALLDERTK KSNRDSLREA VRTFIGYGYN IEPSDQELAD PAVEKVSIDK IRFFRVERSY
     AVRSGKWYFE FEVVTGGDMR VGWARPGCRP DIELGVDDQA FVFEGSRGQR WHQGSGYFGR
     TWQPGDVVGC MINLDDASMI FTLNGELLIT NKGSELAFAD YEIENGFVPI CSLGLSQIGR
     MNLGMDASTF KFYTMCGLQE GFEPFAVNMN RDVAMWFSKR LPTFVNVPKD HPHIEVVRID
     GTMDSPPCLK VTHKTFGTQN SNANMIYCRL SMPVECHSSF SHSPCLDSEA FQKRKQMQEI
     LSHTTTQCYY AIRIFAGQDP SCVWVGWVTP DYHLYSEKFD LNKNCTVTVT LGDERGRVHE
     SVKRSNCYMV WGGDIVASSQ RSSRSNVDLE IGCLVDLAMG MLSFSANGKE LGTCYQVEPN
     TKVFPAVFLQ PTSTSLFQFE LGKLKNAMPL SAAIFKSEEK NPVPQCPPRL DVQTIQPVLW
     SRMPNSFLKV ETERVSERHG WVVQCLEPLQ MMALHIPEEN RCVDILELCE QEDLMQFHYH
     TLRLYSAVCA LGNSRVAYAL CSHVDLSQLF YTIDNKYLPG LLRSGFYDLL ISIHLANAKE
     RKLMMKNEYI IPITSTTRNI RLYPDESKRH GLPGVGLQTC LKPGFRFSTP CFVVTSEEHQ
     KQSPEIPLEI LKTKALSMLT EAVHCSGAHI RDPVGGSVEF QFVPVLKLIG TLLVMGVFDD
     DDVRQILLLI DPSVFGEHSG ESEEGAEKEE VTQVEEKAVE AGEKTSKEPP IKGLLQTRLP
     ESVKLQMCEL LSYLCDCELQ HRVEAIVAFG DIYVSKLQVN QKFRYDELMQ ALNMSAALTA
     RKTKEFRSPP QEQINMLLNF QLGENCPCPE EIREELYDFH EDLLAHCGVP WEEEEEEDED
     TTWAGKLCAL VHKIRGPPKQ EKEPPKEEEE RCPTTLKELV SQTMIRWAQE NQIQDAELVR
     MMFNLLRRQY DSIGELLQAL RKTYTISQAS VSDTINLLAA LGQIRSLLSV RMGKEEELLM
     INGLGDIMNN KVFYQHPNLM RVLGMHETVM EVMVNVLGTE KSQIAFPKMV ASCCRFLCYF
     CRISRQNQKA MFEHLSYLLE NSSVGLASPS MRGSTPLDVA ASSVMDNNEL ALGLEEPDLE
     KVVTYLAGCG LQSCPMLVAK GYPDVGWNPI EGERYLSFLR FAVFVNSESV EENASVVVKL
     LIRRPECFGP ALRGEGGNGL LAAMQGAIKI SENPALDLPS QGYKRDVPDE EEEEEEIVHM
     GNAIMSFYSA LIDLLGRCAP EMHLIQTGKG EAIRIRSILR SLVPTEDLVG IISIPLKLPS
     LNKDGSVSEP DMAANFCPDH KAPMVLFLDR VYGIKDQTFL LHLLEVGFLP DLRASASLDT
     VSLSTTESAL ALNRYICSAV LPLLTRCAPL FAGTEHYTSL IDSTLQTIYR LSKGRSLTKA
     QRDTIEECLL AICNHLRPSM LQQLLRRLVF DVPQLNEYCK MPLKLLTNHY EQCWKYYCLP
     SGWGSYGLAV EEELHLTEKL FWGIFDSLSH KKYDPDLFRM ALPCLSAIAG ALPPDYLDTR
     ITATLEKQVS VDADGNFDPK PINTMNFSLP EKLEYIVTKY AEHSHDKWAC DKSQSGWKYG
     ISLDENVKTH PLIRPFKTLT EKEKEIYRWP ARESLKTMLA VGWTVERTKE GEALVQQREN
     EKLRSVSQTS QGNSYSPAPL DLSNVVLSRE LQGMVEVVAE NYHNIWAKKK KLELESKGGG
     SHPLLVPYDT LTAKEKYRDR EKAQDLFKFL QVNGIIVSRG MKDLELDASS MEKRFAYKFL
     KKILKYVDSA QEFIAHLEAI VSSGKTEKSP HDQEIKFFAK VLLPLVDQYF TNHRLYFLSS
     PLKPLSSSGY ASHKEKEMVA SLFCKLAALV RHRISLFGSD STTMVSCLHI LAQTLDTRTV
     MKSGSELVKA GLRAFFENAA EDLEKTSENL KLGKFTHSRT QIKGVSQNIN YTTVALLPIL
     TSIFEHVAQH QFGVDLLLSD VQISCYHILC SLYSLGTGKN IYVERQRPAL GECLASLAAA
     IPVAFLEPTL NRYNPLSVFN TKTPRERSIL GMPDTVEEMC PDIPQLEGLM KEINDLAESG
     ARYTEMPHVI EVILPMLCNY LSYWWERGPE NLPPSTGPCC TKVTSEHLSL ILGNILKIIN
     NNLGIDEASW MKRIAVFAQP IISKARPDLL RSHFIPTLEK LKKKAVKTVQ EEEQLKADGK
     GDTQEAELLI LDEFAVLCRD LYAFYPMLIR YVDNNRSNWL KSPDADSDQL FRMVAEVFIL
     WCKSHNFKRE EQNFVIQNEI NNLAFLTGDS KSKMSKAMQV KSGGQDQERK KTKRRGDLYS
     IQTSLIVAAL KKMLPIGLNM CTPGDQELIS LAKSRYSCRD TDEEVKEHLR NNLHLQEKSD
     DPAVKWQLNL YKDVLRSEEP SNPEKTVERV QRISAAVFHL EQVEQPLRSK KAVWHKLLSK
     QRKRAVVACF RMAPLYNLPR HRSINLFLHG YQRFWIETEA YSFEEKLVQD LAKSPKVEEE
     EEEEMEKQPD PLHQIILHFS RNALTERSKL EDDPLYTSYS SMMAKSCQSG EDEEEDEDKE
     KTFEEKEMEK QKTLYQQARL HERGAAEMVL QMISASKGEM SPMVVQTLKL GIAILNGGNA
     GVQQKMLDYL KEKKDAGFFQ SLSGLMQSCS VLDLNAFERQ NKAEGLGMVT EEGTLIVRER
     GEKVLQNDEF TRDLFRFLQL LCEGHNSDFQ NFLRTQMGNT TTVNIIISTV DYLLRLQESI
     SDFYWYYSGK DIIDESGQHN FSKALAVTKQ IFNSLTEYIQ GPCIGNQQSL AHSRLWDAVV
     GFLHVFANMQ MKLSQDSSQI ELLKELLDLL QDMVVMLLSL LEGNVVNGTI GKQMVDTLVE
     SSTNVEMILK FFDMFLKLKD LTSSDTFKEY DPDGKGIISK KEFQKAMEGQ KQYTQSEIDF
     LLSCAEADEN DMFNYIDFVD RFHEPAKDIG FNVAVLLTNL SEHMPNDSRL KCLLDPAESV
     LNYFEPYLGR IEIMGGAKKI ERVYFEISES SRTQWEKPQV KESKRQFIFD VVNEGGEQEK
     MELFVNFCED TIFEMQLASQ ISESDSADRP EEEEEENEDS PYVLEIEGEE EEDRSFESSS
     AFAMACASAK RNVANFLKKA TVKNLKKQYR NVKKMTAKEL VKVFFSFFWM LFVGLFQLFF
     TILGGIFQIL WNTVFGGGLV EGAKNIRVTK ILGDMPDPTQ FGIHDDAVEA EKVEVTEPGI
     PTELVHFVKG EKGDADIMSD LFGLHPKKEG GLKHGPEVGL GDLSEIIGKD EPPTLESTVR
     KKRKAQAAEM KAACEAEGKV ESEKADMEDG EKEDKAKEEM QAEDLWAEVT KKKKRRRGQK
     VEKPEALMAN FFKGLEIYQT KLLHYLARNF YNLRFLALFV AFAINFILLF YKVTEEPLEE
     ETEDVANLWN SFNDEEEEEA MVFFVLQEST GYMAPTLRAL AVVHTIISLV CVVGYYCLKV
     PLVVFKREKE IARKLEFDGL YITEQPSEDD IKGQWDRLVI NTPSFPNNYW DKFVKRKVIN
     KYGDLYGAER IAELLGLDKN ALDFSPVEET KAEAASLVSW LSSIDMKYHI WKLGVVFTDN
     SFLYLAWYTT MSVLGHYNNF FFAAHLLDIA MGFKTLRTIL SSVTHNGKQL VLTVGLLAVV
     VYLYTVVAFN FFRKFYNKSE DDDEPDMKCD DMMTCYLFHM YVGVRAGGGI GDEIEDPAGD
     PYEMYRIVFD ITFFFFVIVI LLAIIQGLII DAFGELRDQQ EQVREDMETK CFICGIGNDY
     FDTTPHGFET HTLQEHNLAN YLFFLMYLIN KDETEHTGQE SYVWKMYQER CWDFFPAGDC
     FRKQYEDQLG
//
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