ID A0A287DBQ9_ICTTR Unreviewed; 795 AA.
AC A0A287DBQ9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Anaphase-promoting complex subunit 4 {ECO:0000256|ARBA:ARBA00016067, ECO:0000256|PIRNR:PIRNR037303};
DE AltName: Full=Cyclosome subunit 4 {ECO:0000256|PIRNR:PIRNR037303};
GN Name=ANAPC4 {ECO:0000313|Ensembl:ENSSTOP00000031007.1};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000031007.1, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000031007.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls
CC progression through mitosis and the G1 phase of the cell cycle.
CC {ECO:0000256|PIRNR:PIRNR037303}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|PIRNR:PIRNR037303}.
CC -!- SIMILARITY: Belongs to the APC4 family.
CC {ECO:0000256|PIRNR:PIRNR037303}.
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DR EMBL; AGTP01011338; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A287DBQ9; -.
DR Ensembl; ENSSTOT00000039510.1; ENSSTOP00000031007.1; ENSSTOG00000016156.3.
DR GeneTree; ENSGT00390000004612; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005680; C:anaphase-promoting complex; IEA:UniProtKB-UniRule.
DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0070979; P:protein K11-linked ubiquitination; IEA:UniProtKB-UniRule.
DR GO; GO:0030071; P:regulation of mitotic metaphase/anaphase transition; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR024789; APC4.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR024790; APC4_long_dom.
DR InterPro; IPR017169; APC4_metazoa.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR13260; ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4; 1.
DR PANTHER; PTHR13260:SF0; ANAPHASE-PROMOTING COMPLEX SUBUNIT 4; 1.
DR Pfam; PF12896; ANAPC4; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR PIRSF; PIRSF037303; APC4; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|PIRNR:PIRNR037303};
KW Cell division {ECO:0000256|ARBA:ARBA00022618,
KW ECO:0000256|PIRNR:PIRNR037303};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776, ECO:0000256|PIRNR:PIRNR037303};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PIRNR:PIRNR037303}.
FT DOMAIN 27..117
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT DOMAIN 233..431
FT /note="Anaphase-promoting complex subunit 4 long"
FT /evidence="ECO:0000259|Pfam:PF12896"
FT REGION 740..775
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 751..766
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 759
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000256|PIRSR:PIRSR037303-2"
FT CROSSLNK 785
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000256|PIRSR:PIRSR037303-2"
SQ SEQUENCE 795 AA; 90420 MW; 4A21F3692D7294A9 CRC64;
MLRFPTCFPS FRVVGEKQLP QEIIFLVWSP KRDLIALANT AGEVLLHRLA SFHRVWSFPP
NENTGKEVTC LAWRPDGKLL AFALADTKKI ILCDVEKPES LHSFSVEAPV SCMHWMEVTV
ESSVLTSFYN AEDESNLLLP KLPTLPKNYS STSKIFSEEN SDEIIKLLGD VRLNILVLGG
SSGFIELYAY GMFKIARVTG IAGTCLALCL SSDLKSLSVV TEVSTSGASE VSYFQLETNL
LYTFLPEVTR MARKFTHISA LLQYINLSLT CMCEAWEEIL MQMDSRLTKF VQEKNTTTSV
QDEFMHLLLW GKASAELQTL LMNQLTVKGL KKLGQSIESS YSSIQKLVIS HLQSGSESLL
YHLSELKGMA SWKQKYEPLG LDATGIEDAI TAVGSFILKA NELLQVIDSS MKNFKAFFRW
LYVAMLRMTE DHVLPELNKM TQKDITFVAE FLTEHFNEAP DLYNRKGKYF NVEKVGQYLK
DEDDDLVSPP NTEGNQWYDF LQNSSHLKES PLLFPYYPRK SLHFVKRRME NIIDQCLQKP
AAVIGKSMNQ AICIPLYRDA RRWNNKTSNL HYLLFTILED SLYKMCILRR HTDISQSVSN
GLIGIKFGSF TYATTEKVRR STYSCLDAQF YDDETVTVVL KDTIGREGRD RLLVQLPLSL
VYNSEDSAEY QFTGTYSTRL DEQCSVIPTR TMHFEKHWRL LESMKAQYVA GNGFRKVSCV
LSSNLRHVRV FEMDIDDEWE LDESSDEEEE AGSEPVKIKE ETLSEPEVGT QHTAASALAP
EIVIKVEKLD PELDS
//