ID A0A287DDW5_ICTTR Unreviewed; 2794 AA.
AC A0A287DDW5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Teneurin transmembrane protein 4 {ECO:0000313|Ensembl:ENSSTOP00000031734.1};
GN Name=TENM4 {ECO:0000313|Ensembl:ENSSTOP00000031734.1};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000031734.1, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000031734.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the tenascin family. Teneurin subfamily.
CC {ECO:0000256|ARBA:ARBA00009385}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AGTP01029062; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01029063; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01029064; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01029065; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01029066; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01029067; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01029068; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01029069; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01029070; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01029071; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSSTOT00000036289.1; ENSSTOP00000031734.1; ENSSTOG00000020637.2.
DR GeneTree; ENSGT01030000234566; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR Gene3D; 2.180.10.10; RHS repeat-associated core; 2.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR008969; CarboxyPept-like_regulatory.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR022385; Rhs_assc_core.
DR InterPro; IPR031325; RHS_repeat.
DR InterPro; IPR009471; Ten_N.
DR InterPro; IPR028916; Tox-GHH_dom.
DR InterPro; IPR006530; YD.
DR NCBIfam; TIGR03696; Rhs_assc_core; 1.
DR NCBIfam; TIGR01643; YD_repeat_2x; 2.
DR PANTHER; PTHR11219; TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR PANTHER; PTHR11219:SF9; TENEURIN-4; 1.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF05593; RHS_repeat; 2.
DR Pfam; PF06484; Ten_N; 2.
DR Pfam; PF15636; Tox-GHH; 1.
DR SMART; SM00181; EGF; 8.
DR SUPFAM; SSF63829; Calcium-dependent phosphotriesterase; 1.
DR SUPFAM; SSF49464; Carboxypeptidase regulatory domain-like; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR PROSITE; PS00022; EGF_1; 5.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS51361; TENEURIN_N; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 366..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 26..366
FT /note="Teneurin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51361"
FT DOMAIN 651..683
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 781..812
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 821..856
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 157..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 425..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..52
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..70
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 673..682
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 785..795
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 802..811
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 825..835
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 846..855
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2794 AA; 310752 MW; 3068E327E2B35BC7 CRC64;
MEPDHPVLSA ARTQLVDVEE REPEAMDVKE RKPYRSLTRR RDAERRYTSS SADSEEGKAP
QKSYSSSETL KAYDQDARLA YSGRVKDMVP QEAEEFCRTG TNFTLRELGL GEVTPPHGTL
YRTDIGLPHC GYSMGASSDA DMEADTVLSP EHPVRLWGRS TRSGRSSCLS SRANSNLTLT
DTEHENTETD HPGGLQNHPR LRTPPPPLSH AHTPNQHHAA SINSLNRGNF TPRSNPSPAP
TDHSLSGEPP AGGAQEPAHA QDNWLLNSNI PLETRNLGKQ PFLGTLQDNL IEMDILSASR
HDGAYGDGHF LFKPGGTSPL FCTTSPGYPL TSSTVYSPPP RPLPRSTFSR PAFNLKKPSK
YCNWKCAALS AIVISATLVI LLAYFVAMHL FGLNWHLQPM EGQMYEITED TASSWPVPTD
VSLYPSGGTG LETPDRKGKG ATEGKPSSFF PEDSFIDSGE IDVGRRASQK IPPGTFWRSQ
VFIDHPVHLK FNVSLGKAAL VGIYGRKGLP PSHTQFDFVE LLDGRRLLTQ EARSLEGPQR
QSRGVVPPSS HETGFIQYLD SGIWHLAFYN DGKESEVVSF LTTAIESVDN CPSNCYGNGD
CISGTCHCFL GFLGPDCGRA SCPVLCSGNG QYMKGRCLCH SGWKGAECDV PTNQCIDVAC
SNHGTCIMGT CICNPGYKGE SCEEVDCMDP TCSGRGVCVR GECHCSVGWG GTNCETPRAT
CLDQCSGHGT FLPDTGLCSC DPSWTGHDCS IEICAADCGG HGVCVGGTCR CEDGWMGAAC
DQRACHPRCA EHGTCRDGKC ECSPGWNGEH CTIAHYLDRV VKEGCPGLCN GNGRCTLDLN
GWHCVCQLGW RGAGCDTSME TACGDSKDND GDGLVDCMDP DCCLQPLCHV NPLCLGSPDP
LDIIQETQAP VSQQNLHSFY DRIKFLVGRD STHVIPGENP FDGGHACVIR GQVMTSDGTP
LVGVNISFVN NPLFGYTISR QDGSFDLVTN GGVSIILRFE RAPFITQEHT LWLPWDRFFV
METIIMRHEE NEIPSCDLSN FARPNPVVSP SPLTSFASSC AEKGPIVPEI QALQEEIAIS
GCKMRLSYLS SRTPGYKSVL RISLTHPTIP FNLMKVHLMV AVEGRLFRKW FAAAPDLSYY
FMWDKTDVYN QKVLGLSEAF VSVGYEYESC PDLILWEKRT AVLQGYEIDA SKLGGWSLDK
HHALNIQSGI LHKGNGENQF VSQQPPVIGS IMGNGRRRSI SCPSCNGLAD GNKLLAPVAL
TCGSDGSLYV GDFNYIRRIF PSGNVTNILE LRNKDFRHSH SPAHKYYLTT DPMSGAVFLS
DTNSRRVFKI KSTMVVKDLV KNSEVVAGTG DQCLPFDDSR CGDGGKATEA TLTNPRGITV
DKFGLIYFVD GTMIRRIDQN GIISTLLGSN DLTSARPLSC DSVMDISQVR LEWPTDLAIN
PMDNSLYVLD NNVVLQISEN HQVRIVAGRP MHCQVPGIDH FLLSKVAIHA TLESATALAV
SHNGVLYIAE TDEKKINRIR QVTTSGEISL VAGAPSGCDC KNDANCDCFS GDDGYAKDAK
LNTPSSLAVC ADGELYVADL GNIRIRFIRK NKPFLNTQNM YELSSPIDQE LYLFDTSGKH
LYTQSLPTGD YLYNFTYTGD GDVTLITDNN GNMVNVRRDS TGMPLWLVVP DGQVYWVTMG
TNSALKSVTT QGHELAMMTY HGNSGLLATK SNENGWTTFY EYDSFGRLTN VTFPTGQVSS
FRSDTDSSVH VQVETSSKDD VTITTNLSAS GAFYTLLQDQ VRNSYYIGAD GSLRLLLANG
MEVALQTEPH LLAGTVNPTV GKRNVTLPID NGLNLVEWRQ RKEQARGQVT VFGRRLRVHN
RNLLSLDFDR VTRTEKIYDD HRKFTLRILY DQAGRPSLWS PSSRLNGVNV TYSPGGHIAG
IQRGIMSERM EYDQAGRITS RIFADGKTWS YTYLEKSMVL LLHSQRQYIF EFDKNDRLSS
VTMPNVARQT LETIRSVGYY RNIYQPPEGN ASVIQDFTED GHLLHTYYLG TGRRVIYKYG
KLSKLAETLY DTTKVSFTYD ETAGMLKTIN LQNEGFTCTI RYRQIGPLID RQIFRFTEEG
MVNARFDYNY DNSFRVTSMQ AVINETPLPI DLYRYDDVSG KTEQFGKFGV IYYDINQIIT
TAVMTHTKHF DAYGRMKEVQ YEIFRSLMYW MTVQYDNMGR VVKKELKVGP YANTTRYSYE
YDADGQLQTV SINDKPLWRY SYDLNGNLHL LSPGNSARLT PLRYDLRDRI TRLGDVQYKM
DEDGFLRQRG GDIFEYNSAG LLIKAYNRAG GWSVRYRYDG LGRRVSSKSS HSHHLQFFYA
DLTNPTKVTH LYNHSSSEIT SLYYDLQGHL FAMELSSGDE FYIACDNIGT PLAVFSGTGL
MIKQILYTAY GEIYMDTNPN FQIIIGYHGG LYDPLTKLVH MGRRDYDVLA GRWTSPDHEL
WKHLSSSNIM PFNLYMFKNN NPISNSQDIK CFMTDVNSWL LTFGFQLHNV IPGYPKPDMD
AMEPSYELVH TQMKTQEWDN SKSILGVQCE VQKQLKAFVT LERFDQLYGS TITSCQQAPE
TKKFASSGSV FGKGVKFALK DGRVTTDIIS VANEDGRRVA AILNNAHYLE NLHFTIDGVD
THYFVKPGPS EGDLAILGLS GGRRTLENGV NVTVSQINTM LNGRTRRYTD IQLQYGALCL
NTRYGTTLDE EKARVLELAR QRAVRQAWAR EQQRLREGEE GLRAWTEGEK QQVLNTGRVQ
GYDGFFVISV EQYPELSDSS NNIHFMRQSE MGRR
//